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The map label for this gene is dxr

Identifier: 29347412

GI number: 29347412

Start: 2518622

End: 2519794

Strand: Reverse

Name: dxr

Synonym: BT_2002

Alternate gene names: 29347412

Gene position: 2519794-2518622 (Counterclockwise)

Preceding gene: 29347413

Following gene: 29347411

Centisome position: 40.25

GC content: 55.16

Gene sequence:

>1173_bases
ATGGATTCAGAAAAGAAGAATAAGAAGAAACAAATAGCTATTTTAGGCTCTACGGGCTCTATCGGGACGCAGGCGTTGCA
GGTGATCGAAGAACACCCCGACCTCTACGAAGCCTATGCCCTGACGGCCAACAACCGGGTAGAACTGCTGATTGCACAGG
CACGCAAGTTCCAGCCGGAAGTGGTGGTGATAGCCAACGAAGAAAAGTACGCCCAACTGAAGGAAGCGCTGAGCGACCTT
CCGATCAAAGTATATGCCGGAATCGACGCGGTCTGTCAGATCGTGGAGGCCGGACCGGTAGATATGGTGCTGACGGCAAT
GGTGGGCTATGCCGGACTGAAGCCGACGATCAACGCCATTCGTGCCAAGAAAGCCATTGCGCTTGCCAATAAGGAGACGC
TTGTGGTGGCGGGAGAACTGATCAACCAACTGGCACAGCAATACCACACTCCCATTTTGCCGGTGGACTCTGAACACTCG
GCAGTCTTCCAGTGTTTAGCTGGAGAAGTCGGGAACCCGATTGAGAAGGTGATACTGACCGCTTCCGGTGGTCCGTTTCG
GACCTGCACGCTGGAGCAGCTGAAGTCCGTCACCAAGACACAGGCATTGAAACATCCCAACTGGGAGATGGGAGCCAAGA
TCACCATTGACTCCGCATCCATGATGAACAAAGGCTTTGAGGTCATCGAGGCGAAATGGCTGTTCGGCGTGCAGCCCAGC
CAGATCGAGGTGGTGGTGCATCCGCAGTCGGTCATTCATTCCATGGTGCAGTTTGAGGACGGTGCCGTCAAGGCACAGCT
AGGCATGCCGGATATGCGTCTGCCCATCCAGTATGCGTTCTCGTATCCCGACCGTATCTGCTCTTCTTTCGACAGGCTCG
ACTTCACCCAGTGCACGAACCTGACGTTCGAGCAACCGGATACGAAGCGTTTCCGCAACCTTGCCCTGGCTTACGAGGCG
ATGTATCGGGGCGGAAATATGCCTTGCATTGTCAATGCCGCCAACGAAGTAGTGGTAGCCGCTTTCCTCCGGGACGGCAT
CAGCTTCCTCGGTATGAGCGATGTGATCGAAAAGACAATGGAACGTGCCGCGTTTGTAGCCGCTCCTGCTTACGACGACT
ATGTGGCTACCGACGCTGAAGCGCGGAGAATAGCTGCGGAGCTGATTCCGTGA

Upstream 100 bases:

>100_bases
ACATCCTGTCAATCCGGAGAAATACATCGTGTTTTAAAGCCAATGACGAGAAGTGGGATATACGATTATAAGTGACAAGT
GACAGAGGAATTAGATAATA

Downstream 100 bases:

>100_bases
TAGCACCGGAGCTGATTTCGTGAACAATGAAAAATATAAATAAGTAATATAAATTAGAAAGCGCCTCGGTTTTCCTCTTA
TGAGCAGAGGGTTTGGATGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPEVVVIANEEKYAQLKEALSDL
PIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAIRAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHS
AVFQCLAGEVGNPIEKVILTASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS
QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTNLTFEQPDTKRFRNLALAYEA
MYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTMERAAFVAAPAYDDYVATDAEARRIAAELIP

Sequences:

>Translated_390_residues
MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPEVVVIANEEKYAQLKEALSDL
PIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAIRAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHS
AVFQCLAGEVGNPIEKVILTASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS
QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTNLTFEQPDTKRFRNLALAYEA
MYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTMERAAFVAAPAYDDYVATDAEARRIAAELIP
>Mature_390_residues
MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPEVVVIANEEKYAQLKEALSDL
PIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAIRAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHS
AVFQCLAGEVGNPIEKVILTASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS
QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTNLTFEQPDTKRFRNLALAYEA
MYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTMERAAFVAAPAYDDYVATDAEARRIAAELIP

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=43.8144329896907, Blast_Score=311, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_BACTN (Q8A684)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_810915.1
- ProteinModelPortal:   Q8A684
- SMR:   Q8A684
- GeneID:   1076106
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_2002
- NMPDR:   fig|226186.1.peg.2002
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q8A684
- ProtClustDB:   PRK05447
- BioCyc:   BTHE226186:BT_2002-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42743; Mature: 42743

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: BINDING 131-131 BINDING 158-158 BINDING 182-182 BINDING 205-205 BINDING 227-227

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPE
CCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHEEEECCCCEEEEEEHHHCCCCC
VVVIANEEKYAQLKEALSDLPIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAI
EEEEECCHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHH
RAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHSAVFQCLAGEVGNPIEKVILT
HHHHHHEECCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEE
ASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS
ECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHCCHHHEEEEEEECCCCC
QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTN
EEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCHHEECCCHHHHHHHHCCCCHHHHCC
LTFEQPDTKRFRNLALAYEAMYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTM
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCHHHCCHHHHHHHHH
ERAAFVAAPAYDDYVATDAEARRIAAELIP
HHHHEEECCCCCCHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDSEKKNKKKQIAILGSTGSIGTQALQVIEEHPDLYEAYALTANNRVELLIAQARKFQPE
CCCCHHCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHHEEEECCCCEEEEEEHHHCCCCC
VVVIANEEKYAQLKEALSDLPIKVYAGIDAVCQIVEAGPVDMVLTAMVGYAGLKPTINAI
EEEEECCHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHH
RAKKAIALANKETLVVAGELINQLAQQYHTPILPVDSEHSAVFQCLAGEVGNPIEKVILT
HHHHHHEECCCCEEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEE
ASGGPFRTCTLEQLKSVTKTQALKHPNWEMGAKITIDSASMMNKGFEVIEAKWLFGVQPS
ECCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHCCHHHEEEEEEECCCCC
QIEVVVHPQSVIHSMVQFEDGAVKAQLGMPDMRLPIQYAFSYPDRICSSFDRLDFTQCTN
EEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCHHEECCCHHHHHHHHCCCCHHHHCC
LTFEQPDTKRFRNLALAYEAMYRGGNMPCIVNAANEVVVAAFLRDGISFLGMSDVIEKTM
CCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCHHHCCHHHHHHHHH
ERAAFVAAPAYDDYVATDAEARRIAAELIP
HHHHEEECCCCCCHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928