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The map label for this gene is lacA [H]

Identifier: 29346873

GI number: 29346873

Start: 1802516

End: 1803079

Strand: Reverse

Name: lacA [H]

Synonym: BT_1463

Alternate gene names: 29346873

Gene position: 1803079-1802516 (Counterclockwise)

Preceding gene: 29346875

Following gene: 29346870

Centisome position: 28.8

GC content: 43.79

Gene sequence:

>564_bases
ATGCTTTCGGGAAAAATGTATAATGACTTGTCTGTAGAACTGGTTCAAAGAAGAGAACAGGCTGTTTTCCTGACCAATGA
TTATAATTCCACTTATGGAAAGCCTAAAGAAGTTCGGGAGGCATTGTTACGTAAACTATTGAGGTGTATTGGCAGTAGTG
TTCATTTTGAACCGAATTTCCGGTGTGAGTTTGGATTCAATATCAGTATTGGCAATAATTTCTTCGCCAATTTTGATTGC
ATCATGTTGGACGGAAATCTCATTACGATAGGCGACAATGTATTATTAGGGCCCCGTGTCGGTTTATATACGGCCAATCA
TGCGCTCGATCCGCAGGAACGTCTTATGGGCGGGTGCTATGCCCATCCGATTGTCATTGAAGATAATGTATGGGTAGGTG
CCGGCGTTCATATAATGGGTGGTGTCACTGTCGGGAGAAATTCAGTAATCGGTGCGGGCAGTGTGGTGACAAAGAGCATT
CCGGAGAATGTAATTGCCGCAGGTGTTCCCTGTAAAGTTATTCGGGAAATAACCGATGAAGACAAGACCGGTTTTCTGCC
TTAG

Upstream 100 bases:

>100_bases
TGCCTGTTTTATCTGACTAATTCTGTATATTTGCAAGTATGTCCTGCTTATTAAATAACATCATAATATATATATGGAGA
ATAAAGAATTGCGTGAAAGA

Downstream 100 bases:

>100_bases
TGTTTTACGGATGAACTAGCTCGCTACTTACTGAAATTTAAGGATCGTTTCACAATCCTTTGTCCCGCAATATGCGAAAG
ATTATTCGTCTGACAACTGT

Product: putative acetyltransferase

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLSGKMYNDLSVELVQRREQAVFLTNDYNSTYGKPKEVREALLRKLLRCIGSSVHFEPNFRCEFGFNISIGNNFFANFDC
IMLDGNLITIGDNVLLGPRVGLYTANHALDPQERLMGGCYAHPIVIEDNVWVGAGVHIMGGVTVGRNSVIGAGSVVTKSI
PENVIAAGVPCKVIREITDEDKTGFLP

Sequences:

>Translated_187_residues
MLSGKMYNDLSVELVQRREQAVFLTNDYNSTYGKPKEVREALLRKLLRCIGSSVHFEPNFRCEFGFNISIGNNFFANFDC
IMLDGNLITIGDNVLLGPRVGLYTANHALDPQERLMGGCYAHPIVIEDNVWVGAGVHIMGGVTVGRNSVIGAGSVVTKSI
PENVIAAGVPCKVIREITDEDKTGFLP
>Mature_187_residues
MLSGKMYNDLSVELVQRREQAVFLTNDYNSTYGKPKEVREALLRKLLRCIGSSVHFEPNFRCEFGFNISIGNNFFANFDC
IMLDGNLITIGDNVLLGPRVGLYTANHALDPQERLMGGCYAHPIVIEDNVWVGAGVHIMGGVTVGRNSVIGAGSVVTKSI
PENVIAAGVPCKVIREITDEDKTGFLP

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=184, Percent_Identity=44.0217391304348, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1786664, Length=177, Percent_Identity=41.2429378531073, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1788367, Length=143, Percent_Identity=31.4685314685315, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1788345, Length=104, Percent_Identity=35.5769230769231, Blast_Score=61, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322243, Length=184, Percent_Identity=45.1086956521739, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 20462; Mature: 20462

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSGKMYNDLSVELVQRREQAVFLTNDYNSTYGKPKEVREALLRKLLRCIGSSVHFEPNF
CCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCC
RCEFGFNISIGNNFFANFDCIMLDGNLITIGDNVLLGPRVGLYTANHALDPQERLMGGCY
EEEECEEEEECCCEEECEEEEEECCCEEEECCCEEECCCCEEEECCCCCCHHHHHHCCCC
AHPIVIEDNVWVGAGVHIMGGVTVGRNSVIGAGSVVTKSIPENVIAAGVPCKVIREITDE
CCCEEEECCEEEECCEEEEECEEECCCCEECCCHHHHHHCCCHHHCCCCCHHHHHHHCCC
DKTGFLP
CCCCCCC
>Mature Secondary Structure
MLSGKMYNDLSVELVQRREQAVFLTNDYNSTYGKPKEVREALLRKLLRCIGSSVHFEPNF
CCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCC
RCEFGFNISIGNNFFANFDCIMLDGNLITIGDNVLLGPRVGLYTANHALDPQERLMGGCY
EEEECEEEEECCCEEECEEEEEECCCEEEECCCEEECCCCEEEECCCCCCHHHHHHCCCC
AHPIVIEDNVWVGAGVHIMGGVTVGRNSVIGAGSVVTKSIPENVIAAGVPCKVIREITDE
CCCEEEECCEEEECCEEEEECEEECCCCEECCCHHHHHHCCCHHHCCCCCHHHHHHHCCC
DKTGFLP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]