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The map label for this gene is gcdC [H]

Identifier: 29346858

GI number: 29346858

Start: 1783606

End: 1784130

Strand: Reverse

Name: gcdC [H]

Synonym: BT_1448

Alternate gene names: 29346858

Gene position: 1784130-1783606 (Counterclockwise)

Preceding gene: 29346859

Following gene: 29346857

Centisome position: 28.5

GC content: 46.1

Gene sequence:

>525_bases
ATGGGTACATCGTTAGCGACTTATTATGCCAAGCTTCTGGATATGCCGGACAGTGAATATAAGGTGGAGATTCTGGAAGA
CGGACCGATCAAGAAAATAGCGGTCAACGGTAAAATATATGAGGTCGATTACAATATGGGAGGCGACTCCATTCATTCGA
TCATCATTGATCATCACTCGCATGGAGTGCAGATTTCCCCTTCTTCCAATAATTCTTATACCATTATGAATAAGGGTGAG
CTTTATCAGATAGAGCTACAGGGAGAGATGGAAAAGATACATAATGCCCGTGCCGGTACGGAAGCCGTAGGGCGTCAGGT
GGTACAGGCTCCGATGCCGGGGGTGATCCTGAAAATATATGTGAAGAAGGGAGACGAAGTCAAGCGTGGAGACCCGCTTT
GCGTATTGGTGGCCATGAAAATGGAAAACGAGATTCGTTCTGTCACCGATGGAGTAGTGAAAGAAGTCTTTGTCGAAGCC
GGTATGAAGGTCGGTTTGAACGACCGGATTATGGTGATTGAATGA

Upstream 100 bases:

>100_bases
ATGGCAAGTTGCAGATGACTGCCAATAATTATTGAATAAGTGGAGAGTTGAGAGTTGAAAATTGAAAGTTAAGTTGGTCA
TTCATTAAAATTAGAAAGAT

Downstream 100 bases:

>100_bases
TTCTCAAAAAAAATAAAGGTGTTTTACGTACTTATCTCAAAAGTTTTCTTTACTTTTGGCAGATAAGTACGTATTTATAT
CCGGATGTCTTATGAACAAC

Product: biotin carboxyl carrier protein

Products: NA

Alternate protein names: Biotin carrier [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MGTSLATYYAKLLDMPDSEYKVEILEDGPIKKIAVNGKIYEVDYNMGGDSIHSIIIDHHSHGVQISPSSNNSYTIMNKGE
LYQIELQGEMEKIHNARAGTEAVGRQVVQAPMPGVILKIYVKKGDEVKRGDPLCVLVAMKMENEIRSVTDGVVKEVFVEA
GMKVGLNDRIMVIE

Sequences:

>Translated_174_residues
MGTSLATYYAKLLDMPDSEYKVEILEDGPIKKIAVNGKIYEVDYNMGGDSIHSIIIDHHSHGVQISPSSNNSYTIMNKGE
LYQIELQGEMEKIHNARAGTEAVGRQVVQAPMPGVILKIYVKKGDEVKRGDPLCVLVAMKMENEIRSVTDGVVKEVFVEA
GMKVGLNDRIMVIE
>Mature_173_residues
GTSLATYYAKLLDMPDSEYKVEILEDGPIKKIAVNGKIYEVDYNMGGDSIHSIIIDHHSHGVQISPSSNNSYTIMNKGEL
YQIELQGEMEKIHNARAGTEAVGRQVVQAPMPGVILKIYVKKGDEVKRGDPLCVLVAMKMENEIRSVTDGVVKEVFVEAG
MKVGLNDRIMVIE

Specific function: Biotin carrier subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD) [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=65, Percent_Identity=47.6923076923077, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321376, Length=105, Percent_Identity=41.9047619047619, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319695, Length=97, Percent_Identity=38.1443298969072, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24652212, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24652210, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24652214, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI19921944, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24652216, Length=101, Percent_Identity=37.6237623762376, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI281363050, Length=101, Percent_Identity=37.6237623762376, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24652224, Length=101, Percent_Identity=37.6237623762376, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24652222, Length=101, Percent_Identity=37.6237623762376, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24652220, Length=101, Percent_Identity=37.6237623762376, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24652218, Length=101, Percent_Identity=37.6237623762376, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: =4.1.1.70 [H]

Molecular weight: Translated: 19239; Mature: 19107

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTSLATYYAKLLDMPDSEYKVEILEDGPIKKIAVNGKIYEVDYNMGGDSIHSIIIDHHS
CCCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCEEEEEECCCCCCCEEEEEEEECC
HGVQISPSSNNSYTIMNKGELYQIELQGEMEKIHNARAGTEAVGRQVVQAPMPGVILKIY
CCEEECCCCCCCEEEEECCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEE
VKKGDEVKRGDPLCVLVAMKMENEIRSVTDGVVKEVFVEAGMKVGLNDRIMVIE
EECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEC
>Mature Secondary Structure 
GTSLATYYAKLLDMPDSEYKVEILEDGPIKKIAVNGKIYEVDYNMGGDSIHSIIIDHHS
CCHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCEEEEEECCCCCCCEEEEEEEECC
HGVQISPSSNNSYTIMNKGELYQIELQGEMEKIHNARAGTEAVGRQVVQAPMPGVILKIY
CCEEECCCCCCCEEEEECCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEE
VKKGDEVKRGDPLCVLVAMKMENEIRSVTDGVVKEVFVEAGMKVGLNDRIMVIE
EECCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10027965 [H]