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The map label for this gene is pyrD [H]

Identifier: 29346419

GI number: 29346419

Start: 1255841

End: 1256779

Strand: Reverse

Name: pyrD [H]

Synonym: BT_1009

Alternate gene names: 29346419

Gene position: 1256779-1255841 (Counterclockwise)

Preceding gene: 29346424

Following gene: 29346418

Centisome position: 20.08

GC content: 42.81

Gene sequence:

>939_bases
ATGCTCTTGAACTGGTTAAGAATCTATCGCTATCTGCTTCCGGTTCGTGCATGCGTAAGAGGACACTATCAAGTGGACGA
ACCTTTTTCATACGGAAGTCTGCGATTCAAAAACCGGATAGGCTTGTCTGCCGGATTCGATAAAAATGCGGAAACATTTG
ATGAGTTGGCAGATTTTGGTTTCGGATTTCTGGAAGTGGGGACTGTAACTCCTGATTATCAACCGGGAAATCCTTCTTCC
CGTATCTTCAGGCTGGTAGAAGACGAATCACTGATCTCACGTACAGGGTTCAATAATTGCGGTGTCGATGTAGCTCTGGC
GCATATCAGAAGACACAGAAAACATTCTTACATACTCGGAGTAAATATCAATAAGAATCCGCTTTCTGTCGGTGAGCAGA
TCATCAAAGATTTTGAGCTGGTTTTCACTCGTTTATATGAAAGTGTAGATTATTTTACGTTGAACTGGGGTAGTATAGAT
AAAGAATCATTTGCTAAAGTTTTAGAAAACTTCACAACATTCCGTGAGGCAGTGAACAAACGGTGCAGTATTTTCATTAA
GCTCCCGGCGGATATTGATGAGAAGGAATTGGATCTGGTCATTTCCCTTGCATATAAATATTCCATAGAAGGCTTTATAG
CCACGGGTCCGACGATGGACCGCTCAGAATTGCATCAGACAAAAACAAAACAGTTGGAAAAGATCGGTAACGGTGGCGTC
AGTGGTCGGGGTATCGGAAAGAAATCGCAGAAGGTAGTGCATTATCTGTCCGAGCACACCGACCGCCACTTTCTGATTAT
CGGGGCAGGAGGAATAATGACAGCAGAGGATGCAGCCGATATGATTTCCCAAGGGGCCGATATGGTACAGATTTATTCGG
CATTTATTTATTCCGGTCCTTCTGTTGTTCATAAAATAGGGAAGAAACTTAAACATTAA

Upstream 100 bases:

>100_bases
GTGGATTCATATCTTTAATCTAAAAAACAGATAATTGAAAATGTATAATTTAATCGTTAGACCGTTATTATTTCTCATTG
ATCCTGAAAAAGTACATCGG

Downstream 100 bases:

>100_bases
TCGATATGAAGAAATTAATTTGTATTAGCTTGTATGAGGACTTATCCATGACGACCTATGATTTGTCGAAAGTGGACAAT
GCCGAACTGATTGGAATCGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLLNWLRIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRIGLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSS
RIFRLVEDESLISRTGFNNCGVDVALAHIRRHRKHSYILGVNINKNPLSVGEQIIKDFELVFTRLYESVDYFTLNWGSID
KESFAKVLENFTTFREAVNKRCSIFIKLPADIDEKELDLVISLAYKYSIEGFIATGPTMDRSELHQTKTKQLEKIGNGGV
SGRGIGKKSQKVVHYLSEHTDRHFLIIGAGGIMTAEDAADMISQGADMVQIYSAFIYSGPSVVHKIGKKLKH

Sequences:

>Translated_312_residues
MLLNWLRIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRIGLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSS
RIFRLVEDESLISRTGFNNCGVDVALAHIRRHRKHSYILGVNINKNPLSVGEQIIKDFELVFTRLYESVDYFTLNWGSID
KESFAKVLENFTTFREAVNKRCSIFIKLPADIDEKELDLVISLAYKYSIEGFIATGPTMDRSELHQTKTKQLEKIGNGGV
SGRGIGKKSQKVVHYLSEHTDRHFLIIGAGGIMTAEDAADMISQGADMVQIYSAFIYSGPSVVHKIGKKLKH
>Mature_312_residues
MLLNWLRIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRIGLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSS
RIFRLVEDESLISRTGFNNCGVDVALAHIRRHRKHSYILGVNINKNPLSVGEQIIKDFELVFTRLYESVDYFTLNWGSID
KESFAKVLENFTTFREAVNKRCSIFIKLPADIDEKELDLVISLAYKYSIEGFIATGPTMDRSELHQTKTKQLEKIGNGGV
SGRGIGKKSQKVVHYLSEHTDRHFLIIGAGGIMTAEDAADMISQGADMVQIYSAFIYSGPSVVHKIGKKLKH

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=295, Percent_Identity=31.864406779661, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1787177, Length=306, Percent_Identity=35.6209150326797, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509475, Length=294, Percent_Identity=34.6938775510204, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI281361352, Length=314, Percent_Identity=34.7133757961783, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17137316, Length=314, Percent_Identity=34.7133757961783, Blast_Score=168, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 35189; Mature: 35189

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNWLRIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRIGLSAGFDKNAETFDELADFG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCC
FGFLEVGTVTPDYQPGNPSSRIFRLVEDESLISRTGFNNCGVDVALAHIRRHRKHSYILG
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEE
VNINKNPLSVGEQIIKDFELVFTRLYESVDYFTLNWGSIDKESFAKVLENFTTFREAVNK
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
RCSIFIKLPADIDEKELDLVISLAYKYSIEGFIATGPTMDRSELHQTKTKQLEKIGNGGV
CEEEEEECCCCCCHHHHHHHHHHHHHHEECEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
SGRGIGKKSQKVVHYLSEHTDRHFLIIGAGGIMTAEDAADMISQGADMVQIYSAFIYSGP
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCH
SVVHKIGKKLKH
HHHHHHHHHHCC
>Mature Secondary Structure
MLLNWLRIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRIGLSAGFDKNAETFDELADFG
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCC
FGFLEVGTVTPDYQPGNPSSRIFRLVEDESLISRTGFNNCGVDVALAHIRRHRKHSYILG
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEE
VNINKNPLSVGEQIIKDFELVFTRLYESVDYFTLNWGSIDKESFAKVLENFTTFREAVNK
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
RCSIFIKLPADIDEKELDLVISLAYKYSIEGFIATGPTMDRSELHQTKTKQLEKIGNGGV
CEEEEEECCCCCCHHHHHHHHHHHHHHEECEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
SGRGIGKKSQKVVHYLSEHTDRHFLIIGAGGIMTAEDAADMISQGADMVQIYSAFIYSGP
CCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCH
SVVHKIGKKLKH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA