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The map label for this gene is trxA [H]

Identifier: 29345628

GI number: 29345628

Start: 240357

End: 240821

Strand: Reverse

Name: trxA [H]

Synonym: BT_0218

Alternate gene names: 29345628

Gene position: 240821-240357 (Counterclockwise)

Preceding gene: 29345629

Following gene: 29345615

Centisome position: 3.85

GC content: 40.0

Gene sequence:

>465_bases
ATGAAGAAAGTATTAGCAATGGTAGCTTTTGTCATGCTGAGCGTTATCGTATACGCCTTCAATGACAAACCGGATGCCAA
TCAAGGTAAAAAAGAGGTAACAGGTAACGGTGAAGTCGTCGTAATGGACAAAGAAATGTTTCTGAAAGACGTCTTCGATT
ATGAAAAATCAAAAGAGTGGAAATACAAAGGTGACAAACCTGCCATCATCGACTTATATGCAGACTGGTGTGGTCCTTGT
CGCCAGACAGCCCCAATCATGAAAGAATTGGCAAAGGAATATGCAGGGAAAATAACAATCTACAAAGTCAATGTAGACAA
ACAGAAAGAACTTGCTGCCTTGTTTAACGCAACAAGCATTCCATTGTTTGTATTCATTCCTATGAAAGGAGATCCGCAGC
TTTTCCGTGGAGCGGCTGACAAAGCAACTTACAAGAAAGCTATCGATGAATTTCTACTGAAATAA

Upstream 100 bases:

>100_bases
TCAAAAATGGAGAAGCCGTATGGAGACATTCCGGAGTTATCCACAGTAGTGAATTAAAAGGAATCATCGAACAAAATTAC
ATATAAAAGGAAAATAGCGA

Downstream 100 bases:

>100_bases
AGAGCCCTAATTATAGTGACACTATCCGGTCAGGATAATGACATTATAATATAAAAATGGTGACACTATCCGGTGTGGAT
AGTGTCACCATTTTTATATG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MKKVLAMVAFVMLSVIVYAFNDKPDANQGKKEVTGNGEVVVMDKEMFLKDVFDYEKSKEWKYKGDKPAIIDLYADWCGPC
RQTAPIMKELAKEYAGKITIYKVNVDKQKELAALFNATSIPLFVFIPMKGDPQLFRGAADKATYKKAIDEFLLK

Sequences:

>Translated_154_residues
MKKVLAMVAFVMLSVIVYAFNDKPDANQGKKEVTGNGEVVVMDKEMFLKDVFDYEKSKEWKYKGDKPAIIDLYADWCGPC
RQTAPIMKELAKEYAGKITIYKVNVDKQKELAALFNATSIPLFVFIPMKGDPQLFRGAADKATYKKAIDEFLLK
>Mature_154_residues
MKKVLAMVAFVMLSVIVYAFNDKPDANQGKKEVTGNGEVVVMDKEMFLKDVFDYEKSKEWKYKGDKPAIIDLYADWCGPC
RQTAPIMKELAKEYAGKITIYKVNVDKQKELAALFNATSIPLFVFIPMKGDPQLFRGAADKATYKKAIDEFLLK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=90, Percent_Identity=37.7777777777778, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI87082331, Length=90, Percent_Identity=34.4444444444444, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=78, Percent_Identity=37.1794871794872, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639826, Length=74, Percent_Identity=44.5945945945946, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17530795, Length=86, Percent_Identity=38.3720930232558, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573567, Length=79, Percent_Identity=32.9113924050633, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=35.5263157894737, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=35.5263157894737, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 17461; Mature: 17461

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLAMVAFVMLSVIVYAFNDKPDANQGKKEVTGNGEVVVMDKEMFLKDVFDYEKSKEW
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEECHHHHHHHHHHHHCCCCC
KYKGDKPAIIDLYADWCGPCRQTAPIMKELAKEYAGKITIYKVNVDKQKELAALFNATSI
CCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCCCC
PLFVFIPMKGDPQLFRGAADKATYKKAIDEFLLK
CEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKVLAMVAFVMLSVIVYAFNDKPDANQGKKEVTGNGEVVVMDKEMFLKDVFDYEKSKEW
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEEECHHHHHHHHHHHHCCCCC
KYKGDKPAIIDLYADWCGPCRQTAPIMKELAKEYAGKITIYKVNVDKQKELAALFNATSI
CCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHCCCCC
PLFVFIPMKGDPQLFRGAADKATYKKAIDEFLLK
CEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]