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The map label for this gene is trxA [C]

Identifier: 29345629

GI number: 29345629

Start: 240836

End: 241135

Strand: Reverse

Name: trxA [C]

Synonym: BT_0219

Alternate gene names: 29345629

Gene position: 241135-240836 (Counterclockwise)

Preceding gene: 29345630

Following gene: 29345628

Centisome position: 3.85

GC content: 36.67

Gene sequence:

>300_bases
ATGGAAAAGTTTGAAGATTTAATACAGTCACCGATACCCGTTTTAGTTGATTTCTTTGCAGAATGGTGTGGACCCTGCAA
AGCAATGAAACCCGTTTTAGAAGAATTGAAAACAATGGTAGGAGATAAAGCCCGTATTGTGAAGATAGATGTTGACCAAC
ATGAAGATTTGGCTACTAAATATCGCATACAGGCAGTGCCGACTTTTATTTTATTCAAAAATGGAGAAGCCGTATGGAGA
CATTCCGGAGTTATCCACAGTAGTGAATTAAAAGGAATCATCGAACAAAATTACATATAA

Upstream 100 bases:

>100_bases
GAGATTGAACAAAAACAGCTTTTTCCCGTTATATTAATAAAATAGAAATTATATTTGCAGTCTTCAAAGACTGATATTTA
AATTTAAGAAAGGAAAGATT

Downstream 100 bases:

>100_bases
AAGGAAAATAGCGAATGAAGAAAGTATTAGCAATGGTAGCTTTTGTCATGCTGAGCGTTATCGTATACGCCTTCAATGAC
AAACCGGATGCCAATCAAGG

Product: thioredoxin C-2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 99; Mature: 99

Protein sequence:

>99_residues
MEKFEDLIQSPIPVLVDFFAEWCGPCKAMKPVLEELKTMVGDKARIVKIDVDQHEDLATKYRIQAVPTFILFKNGEAVWR
HSGVIHSSELKGIIEQNYI

Sequences:

>Translated_99_residues
MEKFEDLIQSPIPVLVDFFAEWCGPCKAMKPVLEELKTMVGDKARIVKIDVDQHEDLATKYRIQAVPTFILFKNGEAVWR
HSGVIHSSELKGIIEQNYI
>Mature_99_residues
MEKFEDLIQSPIPVLVDFFAEWCGPCKAMKPVLEELKTMVGDKARIVKIDVDQHEDLATKYRIQAVPTFILFKNGEAVWR
HSGVIHSSELKGIIEQNYI

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=39.3617021276596, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082331, Length=92, Percent_Identity=39.1304347826087, Blast_Score=86, Evalue=5e-19,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=91, Percent_Identity=48.3516483516484, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980565, Length=98, Percent_Identity=40.8163265306122, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=95, Percent_Identity=41.0526315789474, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17507705, Length=65, Percent_Identity=40, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=75, Percent_Identity=40, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532254, Length=83, Percent_Identity=37.3493975903614, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532252, Length=83, Percent_Identity=37.3493975903614, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=38.7096774193548, Blast_Score=73, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=40.4761904761905, Blast_Score=70, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=96, Percent_Identity=37.5, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17648013, Length=84, Percent_Identity=44.047619047619, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583090, Length=84, Percent_Identity=44.047619047619, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573567, Length=87, Percent_Identity=37.9310344827586, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24639826, Length=84, Percent_Identity=35.7142857142857, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=49.1803278688525, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17530795, Length=71, Percent_Identity=35.2112676056338, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24658597, Length=71, Percent_Identity=42.2535211267606, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639068, Length=91, Percent_Identity=32.967032967033, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358065, Length=86, Percent_Identity=38.3720930232558, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11344; Mature: 11344

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKFEDLIQSPIPVLVDFFAEWCGPCKAMKPVLEELKTMVGDKARIVKIDVDQHEDLATK
CCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
YRIQAVPTFILFKNGEAVWRHSGVIHSSELKGIIEQNYI
HHHHCCCEEEEEECCCEEECCCCCEEHHHHHHHHHCCCC
>Mature Secondary Structure
MEKFEDLIQSPIPVLVDFFAEWCGPCKAMKPVLEELKTMVGDKARIVKIDVDQHEDLATK
CCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
YRIQAVPTFILFKNGEAVWRHSGVIHSSELKGIIEQNYI
HHHHCCCEEEEEECCCEEECCCCCEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3040729; 2917572 [H]