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The map label for this gene is lldD [H]

Identifier: 29144104

GI number: 29144104

Start: 3945109

End: 3946299

Strand: Reverse

Name: lldD [H]

Synonym: t3825

Alternate gene names: 29144104

Gene position: 3946299-3945109 (Counterclockwise)

Preceding gene: 29144105

Following gene: 29144103

Centisome position: 82.35

GC content: 59.45

Gene sequence:

>1191_bases
ATGATTATTTCAGCAACCAGCGATTATCGCGCCGCAGCTCAGCGCACGTTGCCTCCTTTCCTCTTCCACTACATCGACGG
CGGCGCGTATGCGGAATATACCCTGCGCCGAAATGTGGAAGACCTGTCGCAAGTCGCTCTGCGCCAGCGCGTGCTGAAAA
ATATGTCCGATTTAAGCCTGGAAACGACCCTGTTTAACGAAACGTTGTCGATGCCGGTGGCATTAGCGCCGGTAGGTCTG
TGCGGCATGTACGCCCGTCGCGGCGAAGTACAGGCCGCCGCCGCCGCAGACGCAAAGGGCATTCCGTTCACCCTTTCCAC
CGTCTCCGTCTGTCCGATTGAAGAAGTAGCCCCCACGCTTAAACGCCCGATGTGGTTCCAGCTTTATGTACTGCGTGACC
GGGGCTTTATGCGTAATGCGCTGGAACGAGCAAAAGCGGCGGGCTGCTCCACGCTGGTCTTTACCGTGGATATGCCGACG
CCGGGCGCGCGCTACCGTGACGCCCACTCCGGGATGAGCGGCCCAAACGCGGCCATGCGCCGTTACTGGCAGGCGGTGAT
GCACCCTAAATGGGCGTGGGATGTCGGCCTGAACGGTCGCCCGCATGATTTAGGCAATATTTCCGCCTATCTGGGTAAAC
CGACCGGCCTTGAGGACTATATCGGCTGGCTGGCAAATAACTTCGATCCGTCCATCTCCTGGAAAGATCTGGAGTGGATA
CGCGAATTCTGGGACGGCCCAATGGTGATCAAAGGGATCCTCGATCCAGAAGATGCCCGCGATGCGGTACGTTTCGGCGC
TGACGGTATCGTGGTGTCGAATCACGGCGGCCGCCAGCTCGATGGCGTGCTCTCTTCCGCCCGCGCCCTGCCCGCCATTG
CCGATGCGGTGAAAGGCGATATCGCCATTCTGGCGGATAGCGGGATTCGTAACGGGCTGGATGTCGTGCGTATGATTGCG
CTGGGGGCCGATACCGTACTGCTGGGTCGGGCCTATCTCTACGCGCTGGCGACGGCAGGAAAAACTGGCGTCGCTAACCT
ACTGGACCTGATCGAGAAAGAGATGAAAGTCGCCATGACCCTGACCGGCGCGAAATCCATTAGCGAAATCAGTGGCGATT
CACTGGTGCAGGAACTGGGGAAAAGTTTGCCCGCCGCGCTGGCGCCAATGAGCAAAGGCGATGCCGCCTGA

Upstream 100 bases:

>100_bases
TCCACACCACGATTAAACGATTTGATGAAGACCAGGCCCGCCAGGCGCGCATTACCCGCCTGCCCGGCGACCATAATGAG
ATGACCAGGGAGAATAAATC

Downstream 100 bases:

>100_bases
ACGTCTGGCGCGTGAGAGCCCGGTAAATTTCTGCTATTCTGCCCCCCGCATTTAAGGGGGCATCATGCTTAACATCGTAC
TCTTCGAACCAGAAATCCCG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIISATSDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGL
CGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTLKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKTGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGKSLPAALAPMSKGDAA

Sequences:

>Translated_396_residues
MIISATSDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGL
CGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTLKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKTGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGKSLPAALAPMSKGDAA
>Mature_396_residues
MIISATSDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNETLSMPVALAPVGL
CGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTLKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKTGVANLLDLIEKEMKVAMTLTGAKSISEISGDSLVQELGKSLPAALAPMSKGDAA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=366, Percent_Identity=33.6065573770492, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI54234014, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI7705393, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1790033, Length=396, Percent_Identity=93.4343434343434, Blast_Score=759, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=34.5013477088949, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=32.7464788732394, Blast_Score=151, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=28.2722513089005, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI78707188, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI281363140, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI78707190, Length=382, Percent_Identity=34.0314136125654, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42775; Mature: 42775

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISATSDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSL
CEECCCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKTGVANLLDLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHE
LTGAKSISEISGDSLVQELGKSLPAALAPMSKGDAA
ECCCHHHHHHCHHHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure
MIISATSDYRAAAQRTLPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSL
CEECCCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNETLSMPVALAPVGLCGMYARRGEVQAAAAADAKGIPFTLSTVSVCPIEEVAPTL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVMHPKWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
REFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKTGVANLLDLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHE
LTGAKSISEISGDSLVQELGKSLPAALAPMSKGDAA
ECCCHHHHHHCHHHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA