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The map label for this gene is lctR [H]

Identifier: 29144105

GI number: 29144105

Start: 3946296

End: 3947072

Strand: Reverse

Name: lctR [H]

Synonym: t3826

Alternate gene names: 29144105

Gene position: 3947072-3946296 (Counterclockwise)

Preceding gene: 29144106

Following gene: 29144104

Centisome position: 82.37

GC content: 57.92

Gene sequence:

>777_bases
GTGATTGTGATGCCAAAACGCCTGTCAGACGAGATTGCCTCTCGCGTGCGGGCGCTGATTGAAGAACAAAACCTGGAAGC
GGGCATGAAATTGCCCGCCGAGCGCCAGTTGGCTCTACAGCTTGGCGTATCACGCAACTCTTTACGCGAAGCGCTGGCGA
AGCTGGTCAGCGAAGGCGTGCTGGTGAGCCGTCGCGGCGGCGGGACATTTGTCCGCTGGCAGCACGAAACCTGGTCTGAA
CAGAATATCGTGCAACCGCTGAAAATGCTGATGGCGAACGATCCGGACTACAGTTTCGACATTCTGGAAGCCCGCCACGC
CATTGAAGCCAGTACGGCCTGGCACGCCGCCATGCGTGCCACCGCCGCCGACAAAGAGAAAATCAGACTCTGCTTTGATG
CGACGCTCAGCGAAGACCCGGATCTCGCCTCCCAGGCCGACGTGCGCTTTCATCTGGCGATCGCGGAAGCCTCGCATAAT
GTGGTGCTGTTGCAAACCATGCGCGGTTTCTTCGACGTCCTGCAATCCTCCGTCAAACAGAGTCGCCAGCGTATGTATCT
CGTTCCGCCCGTATTCTCAAAGCTGACGGAACAACACCAGGCGGTGTTGGACGCCATTCTGGACGGTAACGCCGAGGGCG
CGCGTAAAGCGATGATGGCGCACCTCAGTTTTGTCCACACCACGATTAAACGATTTGATGAAGACCAGGCCCGCCAGGCG
CGCATTACCCGCCTGCCCGGCGACCATAATGAGATGACCAGGGAGAATAAATCATGA

Upstream 100 bases:

>100_bases
CCGATCTGTTCCGTTTTACCGTCAAACACAGCCTGATCTTCACCTGTATGGTGGGCGTGATCACTACGCTTCAGGCCTAT
GTTTTAACCTGGATGATTCC

Downstream 100 bases:

>100_bases
TTATTTCAGCAACCAGCGATTATCGCGCCGCAGCTCAGCGCACGTTGCCTCCTTTCCTCTTCCACTACATCGACGGCGGC
GCGTATGCGGAATATACCCT

Product: DNA-binding transcriptional repressor LldR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MIVMPKRLSDEIASRVRALIEEQNLEAGMKLPAERQLALQLGVSRNSLREALAKLVSEGVLVSRRGGGTFVRWQHETWSE
QNIVQPLKMLMANDPDYSFDILEARHAIEASTAWHAAMRATAADKEKIRLCFDATLSEDPDLASQADVRFHLAIAEASHN
VVLLQTMRGFFDVLQSSVKQSRQRMYLVPPVFSKLTEQHQAVLDAILDGNAEGARKAMMAHLSFVHTTIKRFDEDQARQA
RITRLPGDHNEMTRENKS

Sequences:

>Translated_258_residues
MIVMPKRLSDEIASRVRALIEEQNLEAGMKLPAERQLALQLGVSRNSLREALAKLVSEGVLVSRRGGGTFVRWQHETWSE
QNIVQPLKMLMANDPDYSFDILEARHAIEASTAWHAAMRATAADKEKIRLCFDATLSEDPDLASQADVRFHLAIAEASHN
VVLLQTMRGFFDVLQSSVKQSRQRMYLVPPVFSKLTEQHQAVLDAILDGNAEGARKAMMAHLSFVHTTIKRFDEDQARQA
RITRLPGDHNEMTRENKS
>Mature_258_residues
MIVMPKRLSDEIASRVRALIEEQNLEAGMKLPAERQLALQLGVSRNSLREALAKLVSEGVLVSRRGGGTFVRWQHETWSE
QNIVQPLKMLMANDPDYSFDILEARHAIEASTAWHAAMRATAADKEKIRLCFDATLSEDPDLASQADVRFHLAIAEASHN
VVLLQTMRGFFDVLQSSVKQSRQRMYLVPPVFSKLTEQHQAVLDAILDGNAEGARKAMMAHLSFVHTTIKRFDEDQARQA
RITRLPGDHNEMTRENKS

Specific function: May be a regulatory protein for the LCT genes [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790032, Length=258, Percent_Identity=86.4341085271318, Blast_Score=473, Evalue=1e-135,
Organism=Escherichia coli, GI1786303, Length=232, Percent_Identity=39.6551724137931, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1789353, Length=228, Percent_Identity=32.0175438596491, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790780, Length=235, Percent_Identity=31.9148936170213, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082208, Length=237, Percent_Identity=28.2700421940928, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI48994955, Length=212, Percent_Identity=26.8867924528302, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29085; Mature: 29085

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVMPKRLSDEIASRVRALIEEQNLEAGMKLPAERQLALQLGVSRNSLREALAKLVSEGV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCE
LVSRRGGGTFVRWQHETWSEQNIVQPLKMLMANDPDYSFDILEARHAIEASTAWHAAMRA
EEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TAADKEKIRLCFDATLSEDPDLASQADVRFHLAIAEASHNVVLLQTMRGFFDVLQSSVKQ
HHCCHHHEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHH
SRQRMYLVPPVFSKLTEQHQAVLDAILDGNAEGARKAMMAHLSFVHTTIKRFDEDQARQA
HHHCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RITRLPGDHNEMTRENKS
HHHCCCCCCHHHCCCCCC
>Mature Secondary Structure
MIVMPKRLSDEIASRVRALIEEQNLEAGMKLPAERQLALQLGVSRNSLREALAKLVSEGV
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCE
LVSRRGGGTFVRWQHETWSEQNIVQPLKMLMANDPDYSFDILEARHAIEASTAWHAAMRA
EEEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TAADKEKIRLCFDATLSEDPDLASQADVRFHLAIAEASHNVVLLQTMRGFFDVLQSSVKQ
HHCCHHHEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHH
SRQRMYLVPPVFSKLTEQHQAVLDAILDGNAEGARKAMMAHLSFVHTTIKRFDEDQARQA
HHHCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
RITRLPGDHNEMTRENKS
HHHCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407843; 8041620; 9278503 [H]