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The map label for this gene is proC [H]

Identifier: 28572905

GI number: 28572905

Start: 861255

End: 862145

Strand: Direct

Name: proC [H]

Synonym: TW764

Alternate gene names: 28572905

Gene position: 861255-862145 (Clockwise)

Preceding gene: 28572904

Following gene: 28572906

Centisome position: 93.01

GC content: 46.13

Gene sequence:

>891_bases
GTGCTCCGTTCGTTGCCGCAGAGCAAACCCCTCGATGACCTGATAGGAAGGACTATAGCGGTCATAGGTCTGGGCACTAT
GGGTGCTGCTATTGCCGAAGGAATTGCTCGCGCACGCAAAGCAATGAACGAAGAAATTCCCCGAGGGCAATTCTATTGCA
CAAAAAGGGAATACAAATTTGAACGCAATTCGGTTATTACATCTGAATCGGTTGTCCTTTACATTCAGGATGATCCCGAC
GCAAACATAACGGTCACACAGCGGTCAGATCTTATAATCATTGCAGTAAGGCCTGAACACATTAAGCATGTTCTGAACTC
GATAAGTCCTGCATTAGACAGAAAGAAACTAATAGTCAGTCTTGCAAAAGATGTAAATCTTTCCAATCTTGCAGCTATGC
TGCCCTCCGGGACTGCGATTGTGCGATGTGCAACAAATTTACCGATTACGGTAAGGCACGGTTTTACCGGACTGTCGTGC
AATAAACATGTACTGCCCTCAGATGTAAAGGCCGTATACACGTTATTTGAATTGCTTGGGCGCTGCACAATGCTATCCGA
GGAGCATCTAACCATTGTGTCCGCCATCACCGGATTCTATCCTGTGTATATGCTGTACATGCTAACAAAAATAAAAGAAG
CGACAGAGAAACTTGGCCTGCCAAGGGATATATCACAAGCCGCGGTTGAGACCGCATGGATCGGATATGCGCAGGTTGTG
TTAAAACACAAGACAACAGCAAAGGGCTTGTTACGTCTTATTCCAAGAGGGCCAAGAAGTGCTGTAGTAAAGTGCTTAGA
TAGAACAGATCTCGGCAGCGTGACATACAAGGTGCTTTTGGCGAGCATTGAGCAAGACAGCGAGCTGCTTGATGGAATCA
TTGACCAATGA

Upstream 100 bases:

>100_bases
GTTTGGAGGGCTGATCTTGTTGAGAATGACCCTAAGGCGTTTATCCATGGAAAACCGAACTTAGGCATAATCTGATACAG
CTCACGGAAAGGAAATAGAA

Downstream 100 bases:

>100_bases
TTGACCGGCATGTACGACAATTTATGAAGCCTCTTGACGGGACTTCTCGGGCAGAATATTAAGTTACAGGGTCGCAAAGT
CTGCTACCATAGCAAAGCTC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MLRSLPQSKPLDDLIGRTIAVIGLGTMGAAIAEGIARARKAMNEEIPRGQFYCTKREYKFERNSVITSESVVLYIQDDPD
ANITVTQRSDLIIIAVRPEHIKHVLNSISPALDRKKLIVSLAKDVNLSNLAAMLPSGTAIVRCATNLPITVRHGFTGLSC
NKHVLPSDVKAVYTLFELLGRCTMLSEEHLTIVSAITGFYPVYMLYMLTKIKEATEKLGLPRDISQAAVETAWIGYAQVV
LKHKTTAKGLLRLIPRGPRSAVVKCLDRTDLGSVTYKVLLASIEQDSELLDGIIDQ

Sequences:

>Translated_296_residues
MLRSLPQSKPLDDLIGRTIAVIGLGTMGAAIAEGIARARKAMNEEIPRGQFYCTKREYKFERNSVITSESVVLYIQDDPD
ANITVTQRSDLIIIAVRPEHIKHVLNSISPALDRKKLIVSLAKDVNLSNLAAMLPSGTAIVRCATNLPITVRHGFTGLSC
NKHVLPSDVKAVYTLFELLGRCTMLSEEHLTIVSAITGFYPVYMLYMLTKIKEATEKLGLPRDISQAAVETAWIGYAQVV
LKHKTTAKGLLRLIPRGPRSAVVKCLDRTDLGSVTYKVLLASIEQDSELLDGIIDQ
>Mature_296_residues
MLRSLPQSKPLDDLIGRTIAVIGLGTMGAAIAEGIARARKAMNEEIPRGQFYCTKREYKFERNSVITSESVVLYIQDDPD
ANITVTQRSDLIIIAVRPEHIKHVLNSISPALDRKKLIVSLAKDVNLSNLAAMLPSGTAIVRCATNLPITVRHGFTGLSC
NKHVLPSDVKAVYTLFELLGRCTMLSEEHLTIVSAITGFYPVYMLYMLTKIKEATEKLGLPRDISQAAVETAWIGYAQVV
LKHKTTAKGLLRLIPRGPRSAVVKCLDRTDLGSVTYKVLLASIEQDSELLDGIIDQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=280, Percent_Identity=26.0714285714286, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI24797097, Length=189, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI24797095, Length=189, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI21361454, Length=165, Percent_Identity=28.4848484848485, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786585, Length=276, Percent_Identity=26.8115942028986, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17569021, Length=224, Percent_Identity=27.6785714285714, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358587, Length=159, Percent_Identity=27.0440251572327, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 32556; Mature: 32556

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRSLPQSKPLDDLIGRTIAVIGLGTMGAAIAEGIARARKAMNEEIPRGQFYCTKREYKF
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHCH
ERNSVITSESVVLYIQDDPDANITVTQRSDLIIIAVRPEHIKHVLNSISPALDRKKLIVS
HCCCEEECCEEEEEEECCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
LAKDVNLSNLAAMLPSGTAIVRCATNLPITVRHGFTGLSCNKHVLPSDVKAVYTLFELLG
HHHCCCHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
RCTMLSEEHLTIVSAITGFYPVYMLYMLTKIKEATEKLGLPRDISQAAVETAWIGYAQVV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LKHKTTAKGLLRLIPRGPRSAVVKCLDRTDLGSVTYKVLLASIEQDSELLDGIIDQ
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRSLPQSKPLDDLIGRTIAVIGLGTMGAAIAEGIARARKAMNEEIPRGQFYCTKREYKF
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHCH
ERNSVITSESVVLYIQDDPDANITVTQRSDLIIIAVRPEHIKHVLNSISPALDRKKLIVS
HCCCEEECCEEEEEEECCCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
LAKDVNLSNLAAMLPSGTAIVRCATNLPITVRHGFTGLSCNKHVLPSDVKAVYTLFELLG
HHHCCCHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
RCTMLSEEHLTIVSAITGFYPVYMLYMLTKIKEATEKLGLPRDISQAAVETAWIGYAQVV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LKHKTTAKGLLRLIPRGPRSAVVKCLDRTDLGSVTYKVLLASIEQDSELLDGIIDQ
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]