Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 28572879

GI number: 28572879

Start: 832699

End: 833712

Strand: Reverse

Name: purM [H]

Synonym: TW738

Alternate gene names: 28572879

Gene position: 833712-832699 (Counterclockwise)

Preceding gene: 28572884

Following gene: 28572878

Centisome position: 90.04

GC content: 50.2

Gene sequence:

>1014_bases
ATGATGGATCCTTATGCCGCAGCCGGAGTTGATATTGTGGCCGGGCAGCTCGCTGTGGAGGCCATGCGCCACGCGGTTGA
AGCGACACACAACTCTCGCGTGCCAGAGGGACTAGGTGGTTTTGCCGGACTTTTTGATATATCGTTTCTTAAACGTTATA
GATCTCCTCTGTTAGTCACTTCCACAGACGGTGTTGGAACAAAAGTCGTGATTGCCCAGGAGCTTGATAAGCACGATACT
ATCGGTCAGGACTTGGTTGCTATGGTTGTCGGAGATATAGCTGTTGTTGGCGGCAAGCCTCTTTTTATGACCGACTACAT
AGCCTGTGGAGAGCTTATTCCCGAGCGCATTGCGCAGATTGTTGGAGGTGTGGCACGGGCATGTCAGGAAATTGATTGCG
TCCTGTTGGGCGGGGAAACCGCTGAGCATCCGGAAGTGATGGCGCGGAATCAGTATGACCTTGCCGGCGCTGCAACGGGT
GTCGTCGAGGCAAGTGATTTATTAGGTAAAGACAAAGTAAAAACTGGAGATGTGCTGATAGGTGTCGCATCCTCAGGACT
GCATGCGAATGGCTTCTCACTTGTGCGGAAAATATGCAGGGATGTATCCTTTGCAGAATATTGCCCAGACCTGCAAACGA
CGTGGGGTGAGGCTCTTCTTGAGCCGACTCGTATGTATGTAAACCTGATTCGGGATCTGATCAAGACGGGTAAATTGCAT
GCTGCGAGTCATATAACCGGTGGTGGGATACCGGGGAATTTACCGCGTATTCTGCCAGAGGGGCTAGGTGCTAGACTTCA
TCCATGGCCAATTCCCGATCTCTTCAAAGTACTCTGTGAGTTTGGTAGCTTGTCCCTGTCAGAGGTGAAAAATGCTTGGA
ATTTGGGAATAGGGTTGATTATTGTCGCATCGAGCACCTCTATCCTTGAGGATATTGATGACTCGTGGCAAGCCCGTTTA
ATTGGAGAGGTTATTGATGGTGAAGCAATCCAGTGGACGGGTAGTCTGTCGTAA

Upstream 100 bases:

>100_bases
TACCGGGAGTCAACATCATGTATGAGTGATGCAAGATATACAAATGGTTGACCGGTGTTTAATCTGGAATATACTGGCCG
GAATATACTGGGGTTGAACA

Downstream 100 bases:

>100_bases
ACGGGTCGTCAGTCGTAGATTCTGGCAGAAACTAGCTTTGCTGACAACAAAGAGTTGTGAATTTGGAACACTATTCGCGG
GACAGTGTCCTGCGAGGTGA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MMDPYAAAGVDIVAGQLAVEAMRHAVEATHNSRVPEGLGGFAGLFDISFLKRYRSPLLVTSTDGVGTKVVIAQELDKHDT
IGQDLVAMVVGDIAVVGGKPLFMTDYIACGELIPERIAQIVGGVARACQEIDCVLLGGETAEHPEVMARNQYDLAGAATG
VVEASDLLGKDKVKTGDVLIGVASSGLHANGFSLVRKICRDVSFAEYCPDLQTTWGEALLEPTRMYVNLIRDLIKTGKLH
AASHITGGGIPGNLPRILPEGLGARLHPWPIPDLFKVLCEFGSLSLSEVKNAWNLGIGLIIVASSTSILEDIDDSWQARL
IGEVIDGEAIQWTGSLS

Sequences:

>Translated_337_residues
MMDPYAAAGVDIVAGQLAVEAMRHAVEATHNSRVPEGLGGFAGLFDISFLKRYRSPLLVTSTDGVGTKVVIAQELDKHDT
IGQDLVAMVVGDIAVVGGKPLFMTDYIACGELIPERIAQIVGGVARACQEIDCVLLGGETAEHPEVMARNQYDLAGAATG
VVEASDLLGKDKVKTGDVLIGVASSGLHANGFSLVRKICRDVSFAEYCPDLQTTWGEALLEPTRMYVNLIRDLIKTGKLH
AASHITGGGIPGNLPRILPEGLGARLHPWPIPDLFKVLCEFGSLSLSEVKNAWNLGIGLIIVASSTSILEDIDDSWQARL
IGEVIDGEAIQWTGSLS
>Mature_337_residues
MMDPYAAAGVDIVAGQLAVEAMRHAVEATHNSRVPEGLGGFAGLFDISFLKRYRSPLLVTSTDGVGTKVVIAQELDKHDT
IGQDLVAMVVGDIAVVGGKPLFMTDYIACGELIPERIAQIVGGVARACQEIDCVLLGGETAEHPEVMARNQYDLAGAATG
VVEASDLLGKDKVKTGDVLIGVASSGLHANGFSLVRKICRDVSFAEYCPDLQTTWGEALLEPTRMYVNLIRDLIKTGKLH
AASHITGGGIPGNLPRILPEGLGARLHPWPIPDLFKVLCEFGSLSLSEVKNAWNLGIGLIIVASSTSILEDIDDSWQARL
IGEVIDGEAIQWTGSLS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=332, Percent_Identity=45.1807228915663, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI209869995, Length=332, Percent_Identity=45.1807228915663, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI209869993, Length=332, Percent_Identity=45.1807228915663, Blast_Score=260, Evalue=1e-69,
Organism=Escherichia coli, GI1788845, Length=305, Percent_Identity=43.6065573770492, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17567511, Length=313, Percent_Identity=34.185303514377, Blast_Score=177, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6321203, Length=312, Percent_Identity=40.3846153846154, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24582400, Length=283, Percent_Identity=36.0424028268551, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35780; Mature: 35780

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDPYAAAGVDIVAGQLAVEAMRHAVEATHNSRVPEGLGGFAGLFDISFLKRYRSPLLVT
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
STDGVGTKVVIAQELDKHDTIGQDLVAMVVGDIAVVGGKPLFMTDYIACGELIPERIAQI
ECCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
VGGVARACQEIDCVLLGGETAEHPEVMARNQYDLAGAATGVVEASDLLGKDKVKTGDVLI
HHHHHHHHHHCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEE
GVASSGLHANGFSLVRKICRDVSFAEYCPDLQTTWGEALLEPTRMYVNLIRDLIKTGKLH
EEECCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AASHITGGGIPGNLPRILPEGLGARLHPWPIPDLFKVLCEFGSLSLSEVKNAWNLGIGLI
HHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCEEEE
IVASSTSILEDIDDSWQARLIGEVIDGEAIQWTGSLS
EEECCHHHHHHHCHHHHHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure
MMDPYAAAGVDIVAGQLAVEAMRHAVEATHNSRVPEGLGGFAGLFDISFLKRYRSPLLVT
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
STDGVGTKVVIAQELDKHDTIGQDLVAMVVGDIAVVGGKPLFMTDYIACGELIPERIAQI
ECCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
VGGVARACQEIDCVLLGGETAEHPEVMARNQYDLAGAATGVVEASDLLGKDKVKTGDVLI
HHHHHHHHHHCCEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEE
GVASSGLHANGFSLVRKICRDVSFAEYCPDLQTTWGEALLEPTRMYVNLIRDLIKTGKLH
EEECCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AASHITGGGIPGNLPRILPEGLGARLHPWPIPDLFKVLCEFGSLSLSEVKNAWNLGIGLI
HHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCEEEE
IVASSTSILEDIDDSWQARLIGEVIDGEAIQWTGSLS
EEECCHHHHHHHCHHHHHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA