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The map label for this gene is nrdA [H]

Identifier: 28572843

GI number: 28572843

Start: 794354

End: 796732

Strand: Reverse

Name: nrdA [H]

Synonym: TW702

Alternate gene names: 28572843

Gene position: 796732-794354 (Counterclockwise)

Preceding gene: 28572852

Following gene: 28572842

Centisome position: 86.05

GC content: 44.68

Gene sequence:

>2379_bases
ATGTCACTTACAGTTGTAAAACGTGATGGTCGAAAACAGCAGTATGATTCTAGGAAGGTCTGCGCAGCCATAGAGGAGGC
ACTCTCAGGGTCGAGTGATGCAATAACCGAGCAGCTTTCATCAGAACTTGAGTTGACCCTGTTTGACGGAATAACAACAA
GTCAGCTGGACGAATCACTGATCCAAGTTGCTCTGCAAAACGTAAAAGATGACCCAGTGTACGACAGAGTGGCAACACGC
CTCTTGCTAAAGAGCATATACAGAAGTGTCCTCGGGGAGTACAAAAATTGCTGCCAGTTGCGCGATCTGCATGTGAAACA
CTTTCGTGGATTTATTGAAAAAGGGGTGGAGGAAGGAATCCTTGACAGGCGCCTTGATGGGCGTTTTGACTATGATCGAC
TTTCTCGTGCGCTTGATCCACAGAGGGATACCCTGTTCAAATACATTGGCCTCGTAACTCTGAATAATCGATATGGAATA
AGAGCACGTTCGGGAAAGAATCTTGAAGTTCCACAGTATCTATGGATGAGAATTAGCATGGGCCTTTCTGTGCTCGAGAA
AGACCCCACAGGGTCAGCCTTAAAGTTCTATGAAAAAATGAGCAAACTCGAGTATTTGGCTGCGGGTTCAACTCTTGTGA
ATGCCGGTACCTGCACACCTCAGTTGTCAAACTGTTTTGTCATGGAAATGCAAGATGACATAGAACATATTGCGAAGACC
ACTCGAGATGTTATGTTGCTTACAAAGGGCACGGGCGGAATAGGCCTTAGTGTAACTAAGCTAAGAGCGCAGGGATCCCC
AATAAGAAGCAATAACACTCGCTCAACTGGACCTATACCGTTTATGCATACAATTGATTCTGTTCTCCGCGCAGTTTCTC
GTGGTGGTAAAAAATTCGGCGCATTGTGCTTTTATATGGAGAACTGGCATATGGATTTTCCCGAATTCATTGACCTAAGG
CAAAATTCGGGTGATCCATACAGAAGAACCCGTACAGCAAATACGGCCGTTTGGATAAGCGATGAGTTTATGAAGCGGGT
TATAAACGATCGGGAATGGTATTTGTTTGACCCCCTTGAGACGCCAGATCTCAACGAGCTGTACGGGGCGGAGTTTAGTA
AAAGATATGAATATTACGTGAATCAGGCAGAAGCTGGCAGGCTAAGTATGTTCAAGAAACTTGGTGCTAGAGAGCAGTTT
CGCGCAATACTTATGAGTCTACAGACAACAAGTCATCCCTGGATTACATTCAAGGACACGATTAACTTGAGGGCACTCAA
TAACAACACCGGCACAATACACCTCTCCAACTTATGTACCGAAATATGTCTCCCGCAAGATAGGGAGAATGTGTCAGTTT
GCAATCTCGCCTCGATAAATCTATCGCGCCATTTGATCGACGGGGAAATTGATTGGCAGTTGCTTGAAGAGAGTACAAGG
CTTGCCGTGAGACAGCTTGACAATCTTATTGATATAACTTGCTCATCCGTAAAAGAGTCTGATAATTCCAACAACCTAAA
CAGAGCTATTGGTCTGGGAATTATGGGGTTCACCAATCTTATTGAGCGCTTGGGGTACAGCTATGAATCCGAACAGGCGT
TTGACCTGATAGATAGACTAATGGAACAAATTTCCTTTGTGGCGATTGATGAGTCTTGTAATTTAGCTGAAGAGAGGGGG
CCTTACAAAAATTTTCATGGCTCCCGATGGTCAAAAGGAATGCTTCCGATAGATTCTATAAAGATTGTGTCGCAGAATAG
GGGCGTGCCGGTTTCAGTAAATACATCATATAGGCTCGACTGGGATTCCCTCCGTAAACGGGTTAGGAATGGTATAAGAA
ACGCAACCCTTTTGGCTATTGCACCAACGGCATCCATAGGCCTTGTTGCAGGTACAACTCCAGGATTAGACCCGCAGTTT
TCGCAGATATTCAGTCGTAGCACTTCTTTTGGTAAATTTCTGGAAGTAAATGAGAATCTAGTTCTCGACTTGAAGCGTAG
GGGTCTCTGGGAGAGGGTTAGAGAGGATATTCTGCGCAGCCAGGGGAATATCCAGCAGATAGATGCTATACCCGGCGAAA
TAAAGGCAAATTACAAAACGAGTTTTCAGCTTTCTCCGTACGCGTTTGTGCAAGTTGCTGCCCGGGCGCAAAAATGGGTA
GATCAGGCAATTAGTAGAAATATGTACCTTGAAAGCAGAGATATAAGCGACATGGTGTCAGTCTATACAACAGCTTGGGA
AATGGGCCTAAAAACAACCTATTATTTGCACATGAAGCCAAGACATCAGGCAGAACAGTCAACGGTTAAGGTGAACAAGA
GAACTGAGGGTGGTAACAGAAGAGGGTTTGCTGGATTTTCAAAGAATAAAGATGTGTAG

Upstream 100 bases:

>100_bases
GCAGTAAAACACTATATATCGTGTTTTGTTTGCTATTTAAACACGATATATAGTAGTATCTATTCCGCTTAGCAAAGTGT
TTCTCAGAGAGGGATAATAG

Downstream 100 bases:

>100_bases
TAACACATTTGCATGGGTGATTTTACGCACATAAACTGCGTGGCTGAACAGAATAAAGATCTCTATACGTAAATTAAACA
GATGGAAGGTTAGGAATGGG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 792; Mature: 791

Protein sequence:

>792_residues
MSLTVVKRDGRKQQYDSRKVCAAIEEALSGSSDAITEQLSSELELTLFDGITTSQLDESLIQVALQNVKDDPVYDRVATR
LLLKSIYRSVLGEYKNCCQLRDLHVKHFRGFIEKGVEEGILDRRLDGRFDYDRLSRALDPQRDTLFKYIGLVTLNNRYGI
RARSGKNLEVPQYLWMRISMGLSVLEKDPTGSALKFYEKMSKLEYLAAGSTLVNAGTCTPQLSNCFVMEMQDDIEHIAKT
TRDVMLLTKGTGGIGLSVTKLRAQGSPIRSNNTRSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFIDLR
QNSGDPYRRTRTANTAVWISDEFMKRVINDREWYLFDPLETPDLNELYGAEFSKRYEYYVNQAEAGRLSMFKKLGAREQF
RAILMSLQTTSHPWITFKDTINLRALNNNTGTIHLSNLCTEICLPQDRENVSVCNLASINLSRHLIDGEIDWQLLEESTR
LAVRQLDNLIDITCSSVKESDNSNNLNRAIGLGIMGFTNLIERLGYSYESEQAFDLIDRLMEQISFVAIDESCNLAEERG
PYKNFHGSRWSKGMLPIDSIKIVSQNRGVPVSVNTSYRLDWDSLRKRVRNGIRNATLLAIAPTASIGLVAGTTPGLDPQF
SQIFSRSTSFGKFLEVNENLVLDLKRRGLWERVREDILRSQGNIQQIDAIPGEIKANYKTSFQLSPYAFVQVAARAQKWV
DQAISRNMYLESRDISDMVSVYTTAWEMGLKTTYYLHMKPRHQAEQSTVKVNKRTEGGNRRGFAGFSKNKDV

Sequences:

>Translated_792_residues
MSLTVVKRDGRKQQYDSRKVCAAIEEALSGSSDAITEQLSSELELTLFDGITTSQLDESLIQVALQNVKDDPVYDRVATR
LLLKSIYRSVLGEYKNCCQLRDLHVKHFRGFIEKGVEEGILDRRLDGRFDYDRLSRALDPQRDTLFKYIGLVTLNNRYGI
RARSGKNLEVPQYLWMRISMGLSVLEKDPTGSALKFYEKMSKLEYLAAGSTLVNAGTCTPQLSNCFVMEMQDDIEHIAKT
TRDVMLLTKGTGGIGLSVTKLRAQGSPIRSNNTRSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFIDLR
QNSGDPYRRTRTANTAVWISDEFMKRVINDREWYLFDPLETPDLNELYGAEFSKRYEYYVNQAEAGRLSMFKKLGAREQF
RAILMSLQTTSHPWITFKDTINLRALNNNTGTIHLSNLCTEICLPQDRENVSVCNLASINLSRHLIDGEIDWQLLEESTR
LAVRQLDNLIDITCSSVKESDNSNNLNRAIGLGIMGFTNLIERLGYSYESEQAFDLIDRLMEQISFVAIDESCNLAEERG
PYKNFHGSRWSKGMLPIDSIKIVSQNRGVPVSVNTSYRLDWDSLRKRVRNGIRNATLLAIAPTASIGLVAGTTPGLDPQF
SQIFSRSTSFGKFLEVNENLVLDLKRRGLWERVREDILRSQGNIQQIDAIPGEIKANYKTSFQLSPYAFVQVAARAQKWV
DQAISRNMYLESRDISDMVSVYTTAWEMGLKTTYYLHMKPRHQAEQSTVKVNKRTEGGNRRGFAGFSKNKDV
>Mature_791_residues
SLTVVKRDGRKQQYDSRKVCAAIEEALSGSSDAITEQLSSELELTLFDGITTSQLDESLIQVALQNVKDDPVYDRVATRL
LLKSIYRSVLGEYKNCCQLRDLHVKHFRGFIEKGVEEGILDRRLDGRFDYDRLSRALDPQRDTLFKYIGLVTLNNRYGIR
ARSGKNLEVPQYLWMRISMGLSVLEKDPTGSALKFYEKMSKLEYLAAGSTLVNAGTCTPQLSNCFVMEMQDDIEHIAKTT
RDVMLLTKGTGGIGLSVTKLRAQGSPIRSNNTRSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFIDLRQ
NSGDPYRRTRTANTAVWISDEFMKRVINDREWYLFDPLETPDLNELYGAEFSKRYEYYVNQAEAGRLSMFKKLGAREQFR
AILMSLQTTSHPWITFKDTINLRALNNNTGTIHLSNLCTEICLPQDRENVSVCNLASINLSRHLIDGEIDWQLLEESTRL
AVRQLDNLIDITCSSVKESDNSNNLNRAIGLGIMGFTNLIERLGYSYESEQAFDLIDRLMEQISFVAIDESCNLAEERGP
YKNFHGSRWSKGMLPIDSIKIVSQNRGVPVSVNTSYRLDWDSLRKRVRNGIRNATLLAIAPTASIGLVAGTTPGLDPQFS
QIFSRSTSFGKFLEVNENLVLDLKRRGLWERVREDILRSQGNIQQIDAIPGEIKANYKTSFQLSPYAFVQVAARAQKWVD
QAISRNMYLESRDISDMVSVYTTAWEMGLKTTYYLHMKPRHQAEQSTVKVNKRTEGGNRRGFAGFSKNKDV

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 ATP-cone domains [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=779, Percent_Identity=33.8896020539153, Blast_Score=428, Evalue=1e-119,
Organism=Escherichia coli, GI2367133, Length=784, Percent_Identity=24.7448979591837, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1789030, Length=682, Percent_Identity=25.366568914956, Blast_Score=172, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17555242, Length=782, Percent_Identity=34.7826086956522, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320914, Length=783, Percent_Identity=31.1621966794381, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322123, Length=784, Percent_Identity=31.5051020408163, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI17352481, Length=782, Percent_Identity=32.3529411764706, Blast_Score=407, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90032; Mature: 89900

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTVVKRDGRKQQYDSRKVCAAIEEALSGSSDAITEQLSSELELTLFDGITTSQLDESL
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
IQVALQNVKDDPVYDRVATRLLLKSIYRSVLGEYKNCCQLRDLHVKHFRGFIEKGVEEGI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDRRLDGRFDYDRLSRALDPQRDTLFKYIGLVTLNNRYGIRARSGKNLEVPQYLWMRISM
HHHCCCCCCCHHHHHHHCCCCHHHHHHHHCEEEECCCCCEEECCCCCCCCHHHHHHHHHH
GLSVLEKDPTGSALKFYEKMSKLEYLAAGSTLVNAGTCTPQLSNCFVMEMQDDIEHIAKT
CHHHEECCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEHHHHHHHHHHC
TRDVMLLTKGTGGIGLSVTKLRAQGSPIRSNNTRSTGPIPFMHTIDSVLRAVSRGGKKFG
CCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHH
ALCFYMENWHMDFPEFIDLRQNSGDPYRRTRTANTAVWISDEFMKRVINDREWYLFDPLE
HEEEEEECCCCCCHHHHHHHCCCCCCHHHCCCCCEEEEECHHHHHHHHCCCCEEEECCCC
TPDLNELYGAEFSKRYEYYVNQAEAGRLSMFKKLGAREQFRAILMSLQTTSHPWITFKDT
CCCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECC
INLRALNNNTGTIHLSNLCTEICLPQDRENVSVCNLASINLSRHLIDGEIDWQLLEESTR
EEEEEEECCCCEEEHHHHHHHHCCCCCCCCCCEEEEEECCHHHHEECCCCHHHHHHHHHH
LAVRQLDNLIDITCSSVKESDNSNNLNRAIGLGIMGFTNLIERLGYSYESEQAFDLIDRL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
MEQISFVAIDESCNLAEERGPYKNFHGSRWSKGMLPIDSIKIVSQNRGVPVSVNTSYRLD
HHHHHEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCEEEC
WDSLRKRVRNGIRNATLLAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSFGKFLEVNENL
HHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCCCEEECCCCE
VLDLKRRGLWERVREDILRSQGNIQQIDAIPGEIKANYKTSFQLSPYAFVQVAARAQKWV
EEEEHHCCHHHHHHHHHHHCCCCEEEHHCCCCCEECCCEEEEEECHHHHHHHHHHHHHHH
DQAISRNMYLESRDISDMVSVYTTAWEMGLKTTYYLHMKPRHQAEQSTVKVNKRTEGGNR
HHHHHCCCEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCHHHEEEECCCCCCCC
RGFAGFSKNKDV
CCCCCCCCCCCC
>Mature Secondary Structure 
SLTVVKRDGRKQQYDSRKVCAAIEEALSGSSDAITEQLSSELELTLFDGITTSQLDESL
CEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
IQVALQNVKDDPVYDRVATRLLLKSIYRSVLGEYKNCCQLRDLHVKHFRGFIEKGVEEGI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDRRLDGRFDYDRLSRALDPQRDTLFKYIGLVTLNNRYGIRARSGKNLEVPQYLWMRISM
HHHCCCCCCCHHHHHHHCCCCHHHHHHHHCEEEECCCCCEEECCCCCCCCHHHHHHHHHH
GLSVLEKDPTGSALKFYEKMSKLEYLAAGSTLVNAGTCTPQLSNCFVMEMQDDIEHIAKT
CHHHEECCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEHHHHHHHHHHC
TRDVMLLTKGTGGIGLSVTKLRAQGSPIRSNNTRSTGPIPFMHTIDSVLRAVSRGGKKFG
CCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHH
ALCFYMENWHMDFPEFIDLRQNSGDPYRRTRTANTAVWISDEFMKRVINDREWYLFDPLE
HEEEEEECCCCCCHHHHHHHCCCCCCHHHCCCCCEEEEECHHHHHHHHCCCCEEEECCCC
TPDLNELYGAEFSKRYEYYVNQAEAGRLSMFKKLGAREQFRAILMSLQTTSHPWITFKDT
CCCCHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECC
INLRALNNNTGTIHLSNLCTEICLPQDRENVSVCNLASINLSRHLIDGEIDWQLLEESTR
EEEEEEECCCCEEEHHHHHHHHCCCCCCCCCCEEEEEECCHHHHEECCCCHHHHHHHHHH
LAVRQLDNLIDITCSSVKESDNSNNLNRAIGLGIMGFTNLIERLGYSYESEQAFDLIDRL
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
MEQISFVAIDESCNLAEERGPYKNFHGSRWSKGMLPIDSIKIVSQNRGVPVSVNTSYRLD
HHHHHEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCEEEC
WDSLRKRVRNGIRNATLLAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSFGKFLEVNENL
HHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHCCCCCCCEEECCCCE
VLDLKRRGLWERVREDILRSQGNIQQIDAIPGEIKANYKTSFQLSPYAFVQVAARAQKWV
EEEEHHCCHHHHHHHHHHHCCCCEEEHHCCCCCEECCCEEEEEECHHHHHHHHHHHHHHH
DQAISRNMYLESRDISDMVSVYTTAWEMGLKTTYYLHMKPRHQAEQSTVKVNKRTEGGNR
HHHHHCCCEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHCCHHHEEEECCCCCCCC
RGFAGFSKNKDV
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]