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The map label for this gene is yggV [C]

Identifier: 28572784

GI number: 28572784

Start: 726584

End: 727165

Strand: Reverse

Name: yggV [C]

Synonym: TW639

Alternate gene names: 28572784

Gene position: 727165-726584 (Counterclockwise)

Preceding gene: 28572785

Following gene: 28572782

Centisome position: 78.53

GC content: 49.48

Gene sequence:

>582_bases
ATGGAAATTGTATTCGTTTCAGAAAATGAGAATAAGATTACCGAGGCTCGCGAAATCCTGTTGCCACTCGGATTTCAGCC
AATTTTTTGTGGGGTGACGTGCCGTGAAACCGGCTTGACTTTCACAGAGAATGCGGTACTAAAAGCACAGGCCGCGGTTG
GCTCAGTAAAGGATGTCCCAATTATGGCCGATGATTCGGGGATTTGCGTTGATGCTCTAAACGGAATGCCCGGTGTATTA
TCGAGCCGGTGGTCACAAGATGGAAGAAATATTGATTTACTATTGTGGCAGATGCGGGATGTGCCGGATGTACACCGCAC
TGCACATTTCGTGTGTTCCATCGCGTGTGTTATGCCAAATACCGAGGTGCGAACCGTATCTTCTGTTTGGCACGGCCGGA
TTCTTCATGTTCCGGACGGCACAGGGGGCTTTGGATACGATCCTGTTTTTCTGCCGGACGGATACAGTGTCTCTGCCGCA
GGCCTTGGGTCTGACTTAAAGAACAGGATAAGTCACAGGTACAAGGCGCTTCGGCTTATGTCCTCTCTTTTGAAGAGGAC
TTATTCTTCTTGCCACGCGTGA

Upstream 100 bases:

>100_bases
TTTGAGCAGATGATGGAACTTGCCAAAACAGGTTGCCAAGCCCTAAAGGAGATACAGGCCGCTTCATTGGATTAAAAATA
ATCTGGATTGACTCTATTAA

Downstream 100 bases:

>100_bases
CATAATGTAATACAGCTGACAGTATAACGAGACCGACAGCTAGCAGGATTACTATTTCAATATTGTCTCGAACAATAGGT
ATTCCTGCCAGGAAGAACCC

Product: hypothetical protein

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MEIVFVSENENKITEAREILLPLGFQPIFCGVTCRETGLTFTENAVLKAQAAVGSVKDVPIMADDSGICVDALNGMPGVL
SSRWSQDGRNIDLLLWQMRDVPDVHRTAHFVCSIACVMPNTEVRTVSSVWHGRILHVPDGTGGFGYDPVFLPDGYSVSAA
GLGSDLKNRISHRYKALRLMSSLLKRTYSSCHA

Sequences:

>Translated_193_residues
MEIVFVSENENKITEAREILLPLGFQPIFCGVTCRETGLTFTENAVLKAQAAVGSVKDVPIMADDSGICVDALNGMPGVL
SSRWSQDGRNIDLLLWQMRDVPDVHRTAHFVCSIACVMPNTEVRTVSSVWHGRILHVPDGTGGFGYDPVFLPDGYSVSAA
GLGSDLKNRISHRYKALRLMSSLLKRTYSSCHA
>Mature_193_residues
MEIVFVSENENKITEAREILLPLGFQPIFCGVTCRETGLTFTENAVLKAQAAVGSVKDVPIMADDSGICVDALNGMPGVL
SSRWSQDGRNIDLLLWQMRDVPDVHRTAHFVCSIACVMPNTEVRTVSSVWHGRILHVPDGTGGFGYDPVFLPDGYSVSAA
GLGSDLKNRISHRYKALRLMSSLLKRTYSSCHA

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI31657144, Length=137, Percent_Identity=32.8467153284672, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789324, Length=196, Percent_Identity=39.7959183673469, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17556833, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19920712, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_TROW8 (Q83HF7)

Other databases:

- EMBL:   BX251412
- RefSeq:   NP_789564.1
- ProteinModelPortal:   Q83HF7
- SMR:   Q83HF7
- STRING:   Q83HF7
- GeneID:   1064843
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW639
- eggNOG:   COG0127
- HOGENOM:   HBG697237
- OMA:   TGVTFAE
- PhylomeDB:   Q83HF7
- ProtClustDB:   CLSK230153
- BioCyc:   TWHI218496:TW0609-MONOMER
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 21111; Mature: 21111

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVFVSENENKITEAREILLPLGFQPIFCGVTCRETGLTFTENAVLKAQAAVGSVKDVP
CEEEEEECCCCHHHHHHHHHHCCCCCEEEECEEECCCCCEEECCHHEEHHHHHCCCCCCE
IMADDSGICVDALNGMPGVLSSRWSQDGRNIDLLLWQMRDVPDVHRTAHFVCSIACVMPN
EEECCCCCEEECCCCCCCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEECCC
TEVRTVSSVWHGRILHVPDGTGGFGYDPVFLPDGYSVSAAGLGSDLKNRISHRYKALRLM
CCHHHHHHHHCCEEEECCCCCCCCCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHHH
SSLLKRTYSSCHA
HHHHHHHHHHHCC
>Mature Secondary Structure
MEIVFVSENENKITEAREILLPLGFQPIFCGVTCRETGLTFTENAVLKAQAAVGSVKDVP
CEEEEEECCCCHHHHHHHHHHCCCCCEEEECEEECCCCCEEECCHHEEHHHHHCCCCCCE
IMADDSGICVDALNGMPGVLSSRWSQDGRNIDLLLWQMRDVPDVHRTAHFVCSIACVMPN
EEECCCCCEEECCCCCCCHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHEEECCC
TEVRTVSSVWHGRILHVPDGTGGFGYDPVFLPDGYSVSAAGLGSDLKNRISHRYKALRLM
CCHHHHHHHHCCEEEECCCCCCCCCCCCEECCCCCEEECCCCCHHHHHHHHHHHHHHHHH
SSLLKRTYSSCHA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174