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The map label for this gene is adh [H]

Identifier: 28572596

GI number: 28572596

Start: 485059

End: 486129

Strand: Reverse

Name: adh [H]

Synonym: TW445

Alternate gene names: 28572596

Gene position: 486129-485059 (Counterclockwise)

Preceding gene: 28572600

Following gene: 28572591

Centisome position: 52.5

GC content: 49.77

Gene sequence:

>1071_bases
GTGCGCATGAAAGCGCTTGTTTATCACGGACCTGGAAAAAGGAGTCTGGACACAGTTGATGACCCGACTATAAAGCTTGG
CACGGATGTCATCCTTGAAATGGAGACTACTACGATATGCGGTAGTGATCTTCATATTCTCAAAGGTGATGTTGCGGCCG
TGAAACCGGGTACTGTGCTCGGACATGAAGGGATTGGGAAGATAGTTGAGGTCGGTAAAGACGTTAAATCCCATTCGGTT
GGCGATCGTGTTATCGTCTCTCCAATGTCTTCCTGCGGAGTTTGTAGGTTCTGTAGGGCGAATAATAACGGTCATTGTCT
GGGTGATTCAGAGGGTCCCGGGGGATGGCGTCTTGGTGGTCTGATTAACGGGGTTCAAGCTCAGTTTGCCAGGATACCGC
TTGCAGATAATTCACTTCACAAACTTCCCTCTGGCCTCGATCCAAAGGTTGGCATATTGGTGTCTGATGTTCTTCCGACT
GGCCATGAAGTGGGTGCACAGGCTGGGCAGGTTACTCTCGGTAGTGTAGTTGCCGTAATTGGCTGCGGCCCTGTTGGATT
GGGCGCAATTGTTACGAGCTTGCTTTACTCACCTTCAAAGGTAATTGCAGTTGATGCTGACTCTAACCGTCTTGAGTTAG
CCCGAAAGTTGGGTGCGACAGATACCGTGCGTGTCAATAGGGAAAGGCCTCTTGATGCAATTGAAGATGTTAAGAAGCTC
ACAGAAGGTGGCTTCGGGGTCGATGTTGCGATAGAGGCGGTTGGTGTTCCGGTAACTTTCAGTATGGCGCTTGGGATTGC
TGCGCCCGGTGGGAGAGTTGCCAATATTGGTGTTCATGGGGCACCGGTTGACTTTCCCCTCCAAGACCTGTGGGACAAAA
ACATTGCCGTAACACTGGGCATTGTTAGTACACATACGATTCCCCTCCTTCTTGCTGCGCTTTCTGAGGGCAAAATCGAT
GCAAGTCAATTCGTTACACATGAGTTTGATCTGTCCGATTTGGAGAGGGCGTATGATGTTTTCTCTGCTGCGGCTCAACA
CAACGTCGTCAAGGTAGCTATTAGAGCTTAA

Upstream 100 bases:

>100_bases
TCTTATGTAAACGTGTTAGAATTTGAGAGTGGTTACAGTGTTGTATCCACTTCTTGTGTTTTGCTGTGGGCGGTGTTCTT
CGCCTGTCTAAGAAAGGGTG

Downstream 100 bases:

>100_bases
GCTGAGTTTTTATAAACGCCCGCCGGGGATAACTGGCGGGCGTTTTGTTATAGAAGAGTGCGTTACAGCTGTATTCCTTG
AGCATTGTAATTCCTGAATT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MRMKALVYHGPGKRSLDTVDDPTIKLGTDVILEMETTTICGSDLHILKGDVAAVKPGTVLGHEGIGKIVEVGKDVKSHSV
GDRVIVSPMSSCGVCRFCRANNNGHCLGDSEGPGGWRLGGLINGVQAQFARIPLADNSLHKLPSGLDPKVGILVSDVLPT
GHEVGAQAGQVTLGSVVAVIGCGPVGLGAIVTSLLYSPSKVIAVDADSNRLELARKLGATDTVRVNRERPLDAIEDVKKL
TEGGFGVDVAIEAVGVPVTFSMALGIAAPGGRVANIGVHGAPVDFPLQDLWDKNIAVTLGIVSTHTIPLLLAALSEGKID
ASQFVTHEFDLSDLERAYDVFSAAAQHNVVKVAIRA

Sequences:

>Translated_356_residues
MRMKALVYHGPGKRSLDTVDDPTIKLGTDVILEMETTTICGSDLHILKGDVAAVKPGTVLGHEGIGKIVEVGKDVKSHSV
GDRVIVSPMSSCGVCRFCRANNNGHCLGDSEGPGGWRLGGLINGVQAQFARIPLADNSLHKLPSGLDPKVGILVSDVLPT
GHEVGAQAGQVTLGSVVAVIGCGPVGLGAIVTSLLYSPSKVIAVDADSNRLELARKLGATDTVRVNRERPLDAIEDVKKL
TEGGFGVDVAIEAVGVPVTFSMALGIAAPGGRVANIGVHGAPVDFPLQDLWDKNIAVTLGIVSTHTIPLLLAALSEGKID
ASQFVTHEFDLSDLERAYDVFSAAAQHNVVKVAIRA
>Mature_356_residues
MRMKALVYHGPGKRSLDTVDDPTIKLGTDVILEMETTTICGSDLHILKGDVAAVKPGTVLGHEGIGKIVEVGKDVKSHSV
GDRVIVSPMSSCGVCRFCRANNNGHCLGDSEGPGGWRLGGLINGVQAQFARIPLADNSLHKLPSGLDPKVGILVSDVLPT
GHEVGAQAGQVTLGSVVAVIGCGPVGLGAIVTSLLYSPSKVIAVDADSNRLELARKLGATDTVRVNRERPLDAIEDVKKL
TEGGFGVDVAIEAVGVPVTFSMALGIAAPGGRVANIGVHGAPVDFPLQDLWDKNIAVTLGIVSTHTIPLLLAALSEGKID
ASQFVTHEFDLSDLERAYDVFSAAAQHNVVKVAIRA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=355, Percent_Identity=25.9154929577465, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4501929, Length=335, Percent_Identity=25.6716417910448, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI34577061, Length=335, Percent_Identity=25.9701492537313, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4501933, Length=340, Percent_Identity=24.4117647058824, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71565154, Length=347, Percent_Identity=27.0893371757925, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI71565152, Length=340, Percent_Identity=24.4117647058824, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=24.7222222222222, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=24.6537396121884, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI71743840, Length=339, Percent_Identity=24.188790560472, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI262073058, Length=339, Percent_Identity=24.188790560472, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=379, Percent_Identity=31.6622691292876, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1790045, Length=340, Percent_Identity=30.5882352941176, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1787863, Length=346, Percent_Identity=28.9017341040462, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082125, Length=358, Percent_Identity=29.3296089385475, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788073, Length=360, Percent_Identity=25.8333333333333, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788075, Length=351, Percent_Identity=26.7806267806268, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=27.190332326284, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI226510992, Length=347, Percent_Identity=25.3602305475504, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=28.4552845528455, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081918, Length=251, Percent_Identity=30.2788844621514, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788407, Length=259, Percent_Identity=28.957528957529, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=333, Percent_Identity=27.3273273273273, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=29.3413173652695, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17565904, Length=358, Percent_Identity=29.608938547486, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=359, Percent_Identity=27.5766016713092, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146526, Length=335, Percent_Identity=28.3582089552239, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=343, Percent_Identity=30.3206997084548, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=30.7471264367816, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=363, Percent_Identity=26.1707988980716, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=368, Percent_Identity=25.8152173913043, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6320033, Length=359, Percent_Identity=26.7409470752089, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=376, Percent_Identity=27.3936170212766, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319949, Length=93, Percent_Identity=39.7849462365591, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17137530, Length=337, Percent_Identity=27.5964391691395, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17737897, Length=339, Percent_Identity=28.9085545722714, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737895, Length=337, Percent_Identity=27.893175074184, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221457811, Length=333, Percent_Identity=23.1231231231231, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45551930, Length=333, Percent_Identity=23.1231231231231, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550770, Length=333, Percent_Identity=23.1231231231231, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37026; Mature: 37026

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMKALVYHGPGKRSLDTVDDPTIKLGTDVILEMETTTICGSDLHILKGDVAAVKPGTVL
CCEEEEEEECCCCCCCCCCCCCCEEECCEEEEEEEEEEECCCCCEEEECCEEEECCCCEE
GHEGIGKIVEVGKDVKSHSVGDRVIVSPMSSCGVCRFCRANNNGHCLGDSEGPGGWRLGG
CCCHHHHHHHHCCCHHHCCCCCEEEECCCCCCCEEEEEECCCCCCEECCCCCCCCEEHHH
LINGVQAQFARIPLADNSLHKLPSGLDPKVGILVSDVLPTGHEVGAQAGQVTLGSVVAVI
HHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCHHHCCCCCCEEHHHHEEEE
GCGPVGLGAIVTSLLYSPSKVIAVDADSNRLELARKLGATDTVRVNRERPLDAIEDVKKL
ECCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHH
TEGGFGVDVAIEAVGVPVTFSMALGIAAPGGRVANIGVHGAPVDFPLQDLWDKNIAVTLG
HCCCCCEEEEEEEECCCEEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHCCCCEEEEEE
IVSTHTIPLLLAALSEGKIDASQFVTHEFDLSDLERAYDVFSAAAQHNVVKVAIRA
EHHHHHHHHHHHHHCCCCCCHHHHEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEC
>Mature Secondary Structure
MRMKALVYHGPGKRSLDTVDDPTIKLGTDVILEMETTTICGSDLHILKGDVAAVKPGTVL
CCEEEEEEECCCCCCCCCCCCCCEEECCEEEEEEEEEEECCCCCEEEECCEEEECCCCEE
GHEGIGKIVEVGKDVKSHSVGDRVIVSPMSSCGVCRFCRANNNGHCLGDSEGPGGWRLGG
CCCHHHHHHHHCCCHHHCCCCCEEEECCCCCCCEEEEEECCCCCCEECCCCCCCCEEHHH
LINGVQAQFARIPLADNSLHKLPSGLDPKVGILVSDVLPTGHEVGAQAGQVTLGSVVAVI
HHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCHHHCCCCCCEEHHHHEEEE
GCGPVGLGAIVTSLLYSPSKVIAVDADSNRLELARKLGATDTVRVNRERPLDAIEDVKKL
ECCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHH
TEGGFGVDVAIEAVGVPVTFSMALGIAAPGGRVANIGVHGAPVDFPLQDLWDKNIAVTLG
HCCCCCEEEEEEEECCCEEEEEEEEEECCCCEEEEECCCCCCCCCCHHHHCCCCEEEEEE
IVSTHTIPLLLAALSEGKIDASQFVTHEFDLSDLERAYDVFSAAAQHNVVKVAIRA
EHHHHHHHHHHHHHCCCCCCHHHHEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]