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The map label for this gene is uppS1

Identifier: 28572591

GI number: 28572591

Start: 479180

End: 479956

Strand: Reverse

Name: uppS1

Synonym: TW440

Alternate gene names: 28572591

Gene position: 479956-479180 (Counterclockwise)

Preceding gene: 28572596

Following gene: 28572590

Centisome position: 51.83

GC content: 44.14

Gene sequence:

>777_bases
TTGGGCGGGAAAATGCTTAGATCTGTTTCTGAACTTATTTACAAGGTGTACGCACGGTATCTTTTAGGACAGATTAACCT
AAATAACCTGCCAGGGCATGTTGCACTAATTGTTGATGGGAACAGGCGATGGGCACGTAAAGAGAAGCGTGATCGAATTT
CCGACGGGCACAGGGCGGGGGCTGGTAAAGCTGTTGATTTTCTGCATTGGTGCGATGAGCTCGATATAAATATCGTAACG
CTATACTTATTGTCTAATGACAACCTAAAAAACAGGAACCGCCAGGAGCTAAATGACCTGGTGCAGGTTATATGCAACCT
AATTGCACAAGTTTCCAAGAGATGGAAAGTAAATCATGTCGGATCCTGCGAAAATCTACCGGAGTTGCTAGGTAACAGCC
TAGAGGGCGTAAAATCTAGTACCAAAACCAACAGGTATTCAGAAAGGTCTATGACTGTAAATCTCGCAATTGGATACAGT
GGTAGAGCGGAAATTACCGAGGCTGTTAGAAAAATAGTCAATACGTATCCAATTGGAGATCTGCCAGAGAAGATAACCGA
AGAGGTTATATCAGCAAATCTGTATACTGGGGGATTATCTGACCCAGACTTGATAATAAGAACAAGCGGAGAACAAAGAC
TGTCAGACTTCATGCCATGGCAGAGCACACACAGCGAATTCTATTTTCTCGAGGCTCTAGGCCCGGACCTTAGGAAAGTA
GACTTCCTTAGGGCAATACGGGATTTTTCAATAAGGAGAAGGAGTTTCGGCGCGTGA

Upstream 100 bases:

>100_bases
ATACCTCAGGGCTGCAGCGCCTTGAAGCACAACGTAGCACCAAAAAGCTACCCAATAACTCTTATCATAGATAAGCACCC
TGACAAAGCATAAAAGCGTA

Downstream 100 bases:

>100_bases
CGTGGGGCGGACGGGACTCGAACCCGTGACCGACGAATTATGAGTTCGCAGCTCTAACCAGCTGAGCTACCGCCCCACAA
AATCCTATCAAAGGCAGTTT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKRDRISDGHRAGAGKAVDFLHWCDELDINIVT
LYLLSNDNLKNRNRQELNDLVQVICNLIAQVSKRWKVNHVGSCENLPELLGNSLEGVKSSTKTNRYSERSMTVNLAIGYS
GRAEITEAVRKIVNTYPIGDLPEKITEEVISANLYTGGLSDPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKV
DFLRAIRDFSIRRRSFGA

Sequences:

>Translated_258_residues
MGGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKRDRISDGHRAGAGKAVDFLHWCDELDINIVT
LYLLSNDNLKNRNRQELNDLVQVICNLIAQVSKRWKVNHVGSCENLPELLGNSLEGVKSSTKTNRYSERSMTVNLAIGYS
GRAEITEAVRKIVNTYPIGDLPEKITEEVISANLYTGGLSDPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKV
DFLRAIRDFSIRRRSFGA
>Mature_257_residues
GGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKRDRISDGHRAGAGKAVDFLHWCDELDINIVTL
YLLSNDNLKNRNRQELNDLVQVICNLIAQVSKRWKVNHVGSCENLPELLGNSLEGVKSSTKTNRYSERSMTVNLAIGYSG
RAEITEAVRKIVNTYPIGDLPEKITEEVISANLYTGGLSDPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKVD
FLRAIRDFSIRRRSFGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=249, Percent_Identity=31.7269076305221, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI45580738, Length=249, Percent_Identity=31.7269076305221, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786371, Length=232, Percent_Identity=33.1896551724138, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71993029, Length=234, Percent_Identity=29.9145299145299, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319474, Length=233, Percent_Identity=30.9012875536481, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=27.0742358078603, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=34.6666666666667, Blast_Score=121, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS1_TROW8 (Q83HR7)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789371.1
- ProteinModelPortal:   Q83HR7
- SMR:   Q83HR7
- STRING:   Q83HR7
- GeneID:   1064282
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW440
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   HLYTSGQ
- ProtClustDB:   PRK14828
- BioCyc:   TWHI218496:TW0416-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29284; Mature: 29153

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 39-39

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKRDRISDGHRAG
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC
AGKAVDFLHWCDELDINIVTLYLLSNDNLKNRNRQELNDLVQVICNLIAQVSKRWKVNHV
CCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GSCENLPELLGNSLEGVKSSTKTNRYSERSMTVNLAIGYSGRAEITEAVRKIVNTYPIGD
CCCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
LPEKITEEVISANLYTGGLSDPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKV
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCEEEHHHCCCCHHHH
DFLRAIRDFSIRRRSFGA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKRDRISDGHRAG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC
AGKAVDFLHWCDELDINIVTLYLLSNDNLKNRNRQELNDLVQVICNLIAQVSKRWKVNHV
CCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
GSCENLPELLGNSLEGVKSSTKTNRYSERSMTVNLAIGYSGRAEITEAVRKIVNTYPIGD
CCCCHHHHHHCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCC
LPEKITEEVISANLYTGGLSDPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKV
CHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHCCCCCCCCCCEEEHHHCCCCHHHH
DFLRAIRDFSIRRRSFGA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174