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The map label for this gene is zwf [H]

Identifier: 28572579

GI number: 28572579

Start: 465159

End: 466622

Strand: Reverse

Name: zwf [H]

Synonym: TW428

Alternate gene names: 28572579

Gene position: 466622-465159 (Counterclockwise)

Preceding gene: 28572580

Following gene: 28572566

Centisome position: 50.39

GC content: 42.83

Gene sequence:

>1464_bases
ATGCCAAAGGTGAATTGCGCAACACAGCAGATTGCCCTGCCTGGGGCGCTTGCTATATTCGGGGCAACGGGTGACCTGAG
CTCCAAAAAACTATTGCCAGCGGTGTACGACTTGTTTCATAACTCTCTTCTATCAAATGGGTTCGTTTTAATTGCTCTGA
ATAGAGACTTCTCGGCGCAAGATTTTATCTGTCACTTCCGCCATTGCGTTAAGTCTTTCTCTAGGACGGGATGGTCAGAG
TCTGTTTTTCTTGATCTCCAAAAAAGGGTACATCATGTAAGTGGCGACTTTTCCGACCCCGAGACATATATTGAGCTCTC
TGAGAAATTAGAAACCACCAAAGAGGAAACTGGGGGTAATTGTGTTTTTTATCTCTCAGTTCCGCCAAATGTATTTACTC
CCATCATGAAAAACTTGTCTGCTAGTGGGCTGTCTAGAGGATGTTTGCATAAAATTGCTGTTGAAAAACCCTTTGGTAAT
GACCTTAAAAGTGCAATACAGCTTAATTCAGTGCTTAGGTCAGCTTTCCCTGAGCGTGCTATCTTTCGGGTTGATCACTA
TCTTGGTAAAGAGACCATTCAAAATATTCTTACTTTTCGTTTTGGAAACCAAATCTTTGACCCTATTTGGAATAGGAAAC
ATGTTGATCATGTGCAGATTACGATGTCTGAAGATATAGGGGTTGAGGGTCGCAGTAAGTACTATGACGGAATCGGTGCT
GCACGTGATGTATTACAAAATCATCTTTTGCAGCTTATGGCTCTAATTACGATGGAGAGACCCTCGAATTTGAATAACGC
GAGTGATATAAGGCACGAGAAGCAGAGAGTTTTGGAATGTGTGAGTCTTCCGAAAAATATAGCTCAAAATGCTGTTCGTG
GCCAATACTCATCCGGCTATCTACGGGATGAGAGGGTTGTATCTTTTTTGCAAGAAGATGGGGTTAATCCATCTTCAAGA
ACTGAAACATTCGCGGCGATAAAGCTAAATGCCGATAATGAACGTTGGTATGGTGTACCTTTCTACGTTAGAACTGGGAA
ACGGATGGCAAAACGTAGTGCATATATAAGTCTTGTATTCAAGCCAACTGATATGAGTATTTTGCAAAATGTGATTGTTA
TAAGGTTGCAACCAGACGAGGGTGTGTCTATTTGGTTTGCGTCGAAAGTGCCCGGTTATCGTTCTGATATTCGACAGGTG
AATTTTGATTTTTCGTATAAAAGCTCATTTACTGAATCAAGTCCAGAGGCTTATGAACGCTTAATTCTGGATGCAATGAG
GGGTGAGGCCTCCTTGTTTCCGCAGCAAAGAGAAGTGGAGTTGTGTTGGGGCATAATAGACCCCCTTGAGGAGGTTTGGG
AAAACGACAATACCCTGATACCCCAATACACTCCAGGAAGTTGGGGGCCAGATACTTCAAACGACCTTTTGCTCAGAACG
TCCAGGCACTGGAGAAATTACTGA

Upstream 100 bases:

>100_bases
TTCATTAGAAGATCTGACTTTGAATCTGCCAGGCCTAGAGCCATCTCTATCCAATTGAACTGATCGCGCATATGGATTTT
AAAACAGAAGTGGAATATAA

Downstream 100 bases:

>100_bases
TTATAAGTCTTCTTCTTGAAGCTCAAACCTCCCAGGATGCCTACAACGACCAGTACGGCGCAGGGAAGAAGTAAAACTTT
TAAGTCGAATATAAGAAATA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MPKVNCATQQIALPGALAIFGATGDLSSKKLLPAVYDLFHNSLLSNGFVLIALNRDFSAQDFICHFRHCVKSFSRTGWSE
SVFLDLQKRVHHVSGDFSDPETYIELSEKLETTKEETGGNCVFYLSVPPNVFTPIMKNLSASGLSRGCLHKIAVEKPFGN
DLKSAIQLNSVLRSAFPERAIFRVDHYLGKETIQNILTFRFGNQIFDPIWNRKHVDHVQITMSEDIGVEGRSKYYDGIGA
ARDVLQNHLLQLMALITMERPSNLNNASDIRHEKQRVLECVSLPKNIAQNAVRGQYSSGYLRDERVVSFLQEDGVNPSSR
TETFAAIKLNADNERWYGVPFYVRTGKRMAKRSAYISLVFKPTDMSILQNVIVIRLQPDEGVSIWFASKVPGYRSDIRQV
NFDFSYKSSFTESSPEAYERLILDAMRGEASLFPQQREVELCWGIIDPLEEVWENDNTLIPQYTPGSWGPDTSNDLLLRT
SRHWRNY

Sequences:

>Translated_487_residues
MPKVNCATQQIALPGALAIFGATGDLSSKKLLPAVYDLFHNSLLSNGFVLIALNRDFSAQDFICHFRHCVKSFSRTGWSE
SVFLDLQKRVHHVSGDFSDPETYIELSEKLETTKEETGGNCVFYLSVPPNVFTPIMKNLSASGLSRGCLHKIAVEKPFGN
DLKSAIQLNSVLRSAFPERAIFRVDHYLGKETIQNILTFRFGNQIFDPIWNRKHVDHVQITMSEDIGVEGRSKYYDGIGA
ARDVLQNHLLQLMALITMERPSNLNNASDIRHEKQRVLECVSLPKNIAQNAVRGQYSSGYLRDERVVSFLQEDGVNPSSR
TETFAAIKLNADNERWYGVPFYVRTGKRMAKRSAYISLVFKPTDMSILQNVIVIRLQPDEGVSIWFASKVPGYRSDIRQV
NFDFSYKSSFTESSPEAYERLILDAMRGEASLFPQQREVELCWGIIDPLEEVWENDNTLIPQYTPGSWGPDTSNDLLLRT
SRHWRNY
>Mature_486_residues
PKVNCATQQIALPGALAIFGATGDLSSKKLLPAVYDLFHNSLLSNGFVLIALNRDFSAQDFICHFRHCVKSFSRTGWSES
VFLDLQKRVHHVSGDFSDPETYIELSEKLETTKEETGGNCVFYLSVPPNVFTPIMKNLSASGLSRGCLHKIAVEKPFGND
LKSAIQLNSVLRSAFPERAIFRVDHYLGKETIQNILTFRFGNQIFDPIWNRKHVDHVQITMSEDIGVEGRSKYYDGIGAA
RDVLQNHLLQLMALITMERPSNLNNASDIRHEKQRVLECVSLPKNIAQNAVRGQYSSGYLRDERVVSFLQEDGVNPSSRT
ETFAAIKLNADNERWYGVPFYVRTGKRMAKRSAYISLVFKPTDMSILQNVIVIRLQPDEGVSIWFASKVPGYRSDIRQVN
FDFSYKSSFTESSPEAYERLILDAMRGEASLFPQQREVELCWGIIDPLEEVWENDNTLIPQYTPGSWGPDTSNDLLLRTS
RHWRNY

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=471, Percent_Identity=36.5180467091295, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI108773793, Length=471, Percent_Identity=36.5180467091295, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI52145310, Length=361, Percent_Identity=34.0720221606648, Blast_Score=182, Evalue=7e-46,
Organism=Escherichia coli, GI1788158, Length=495, Percent_Identity=36.5656565656566, Blast_Score=341, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17538218, Length=479, Percent_Identity=34.2379958246347, Blast_Score=286, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324088, Length=467, Percent_Identity=36.1884368308351, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643350, Length=470, Percent_Identity=33.4042553191489, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24643352, Length=470, Percent_Identity=33.1914893617021, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI221513548, Length=478, Percent_Identity=27.8242677824268, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55323; Mature: 55192

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVNCATQQIALPGALAIFGATGDLSSKKLLPAVYDLFHNSLLSNGFVLIALNRDFSAQ
CCCCCCCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCHH
DFICHFRHCVKSFSRTGWSESVFLDLQKRVHHVSGDFSDPETYIELSEKLETTKEETGGN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
CVFYLSVPPNVFTPIMKNLSASGLSRGCLHKIAVEKPFGNDLKSAIQLNSVLRSAFPERA
EEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHH
IFRVDHYLGKETIQNILTFRFGNQIFDPIWNRKHVDHVQITMSEDIGVEGRSKYYDGIGA
HHHHHHHHCHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHCHHH
ARDVLQNHLLQLMALITMERPSNLNNASDIRHEKQRVLECVSLPKNIAQNAVRGQYSSGY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LRDERVVSFLQEDGVNPSSRTETFAAIKLNADNERWYGVPFYVRTGKRMAKRSAYISLVF
CCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEECCCEEEECCHHHHHCCEEEEEEE
KPTDMSILQNVIVIRLQPDEGVSIWFASKVPGYRSDIRQVNFDFSYKSSFTESSPEAYER
CCCCHHHHCCEEEEEECCCCCCEEEEECCCCCHHHHHHEECCCCCCCCCCCCCCHHHHHH
LILDAMRGEASLFPQQREVELCWGIIDPLEEVWENDNTLIPQYTPGSWGPDTSNDLLLRT
HHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCEEEEE
SRHWRNY
CHHCCCC
>Mature Secondary Structure 
PKVNCATQQIALPGALAIFGATGDLSSKKLLPAVYDLFHNSLLSNGFVLIALNRDFSAQ
CCCCCCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCHH
DFICHFRHCVKSFSRTGWSESVFLDLQKRVHHVSGDFSDPETYIELSEKLETTKEETGGN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
CVFYLSVPPNVFTPIMKNLSASGLSRGCLHKIAVEKPFGNDLKSAIQLNSVLRSAFPERA
EEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHH
IFRVDHYLGKETIQNILTFRFGNQIFDPIWNRKHVDHVQITMSEDIGVEGRSKYYDGIGA
HHHHHHHHCHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHCHHH
ARDVLQNHLLQLMALITMERPSNLNNASDIRHEKQRVLECVSLPKNIAQNAVRGQYSSGY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LRDERVVSFLQEDGVNPSSRTETFAAIKLNADNERWYGVPFYVRTGKRMAKRSAYISLVF
CCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEECCCEEEECCHHHHHCCEEEEEEE
KPTDMSILQNVIVIRLQPDEGVSIWFASKVPGYRSDIRQVNFDFSYKSSFTESSPEAYER
CCCCHHHHCCEEEEEECCCCCCEEEEECCCCCHHHHHHEECCCCCCCCCCCCCCHHHHHH
LILDAMRGEASLFPQQREVELCWGIIDPLEEVWENDNTLIPQYTPGSWGPDTSNDLLLRT
HHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCEEEEE
SRHWRNY
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]