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The map label for this gene is gmk

Identifier: 28572559

GI number: 28572559

Start: 444443

End: 445024

Strand: Direct

Name: gmk

Synonym: TW406

Alternate gene names: 28572559

Gene position: 444443-445024 (Clockwise)

Preceding gene: 28572558

Following gene: 28572560

Centisome position: 48.0

GC content: 44.33

Gene sequence:

>582_bases
ATGCAGCTTTTTGACTTATGGACTGACCTTTTGGATCTTTTGACCATTGTTGCCGGGCCAACGGCAGTTGGTAAGGGTAC
GGTTATAAGCCATTTAAGAAAATGTCACCCTCAAGTCAAAGTTTCTATATCTGCTACAACAAGAGAGCCGAGGGATAGCG
AAAGAGATGGTATTGATTATTATTTTGTTACCGATGAGGTATTTGATTGCATGGTAAGAAGTGGGCAAATGCTTGAATGG
GCCACCGTGCATGGCCTTCACAAATACGGAACGCCAAAGGAAGAAGTTGAACGTCTGCTGCACACGGGCCAGCCGGTCAT
ACTCGAAATTGATCTCCAAGGAATGCGCAAGGTAAGGAAGATATTGCCTGCAGTTAGAACGGTTATTTTACTGCCTCCCG
CTTGGGATGACTTGATTTGTAGAATAAAACGCCGCGGGAGTGAATCACAGGATGAAATTGATGCACGTCTGGCAACAGCA
AAAAAGGAACTTGAGGCTATAGGCGAGTTTGACTACAAGATTGTCAATGCTGATGTTGAAATTGCGGCAAATGAATTATG
GCTGGCCATGAATCGTGTTTAA

Upstream 100 bases:

>100_bases
TGAACTGGGCATTGCTTCCCGTAAACGAATTGCGGGTCTTGGGTCGCTTCAATATGTTCGTCTTGAGGCATTTTTGAAAA
CTCATCTTGGAATACAAAGG

Downstream 100 bases:

>100_bases
CAACATCTGGCTATATTTACTCTTGCTAGAGTTCTGTTGTTTACAGCATTGTTTTGGGTTAGTATATTTGCTGTTCGGTT
TATTTGGAAAATGTAAATAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MQLFDLWTDLLDLLTIVAGPTAVGKGTVISHLRKCHPQVKVSISATTREPRDSERDGIDYYFVTDEVFDCMVRSGQMLEW
ATVHGLHKYGTPKEEVERLLHTGQPVILEIDLQGMRKVRKILPAVRTVILLPPAWDDLICRIKRRGSESQDEIDARLATA
KKELEAIGEFDYKIVNADVEIAANELWLAMNRV

Sequences:

>Translated_193_residues
MQLFDLWTDLLDLLTIVAGPTAVGKGTVISHLRKCHPQVKVSISATTREPRDSERDGIDYYFVTDEVFDCMVRSGQMLEW
ATVHGLHKYGTPKEEVERLLHTGQPVILEIDLQGMRKVRKILPAVRTVILLPPAWDDLICRIKRRGSESQDEIDARLATA
KKELEAIGEFDYKIVNADVEIAANELWLAMNRV
>Mature_193_residues
MQLFDLWTDLLDLLTIVAGPTAVGKGTVISHLRKCHPQVKVSISATTREPRDSERDGIDYYFVTDEVFDCMVRSGQMLEW
ATVHGLHKYGTPKEEVERLLHTGQPVILEIDLQGMRKVRKILPAVRTVILLPPAWDDLICRIKRRGSESQDEIDARLATA
KKELEAIGEFDYKIVNADVEIAANELWLAMNRV

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=180, Percent_Identity=32.7777777777778, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI4504221, Length=180, Percent_Identity=32.7777777777778, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI226874831, Length=180, Percent_Identity=32.7777777777778, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI21389483, Length=194, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI38570142, Length=181, Percent_Identity=24.8618784530387, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=175, Percent_Identity=39.4285714285714, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=32.9545454545455, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=32.9545454545455, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=175, Percent_Identity=35.4285714285714, Blast_Score=115, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21356141, Length=175, Percent_Identity=30.8571428571429, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_TROW8 (Q83HT8)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789339.1
- ProteinModelPortal:   Q83HT8
- SMR:   Q83HT8
- STRING:   Q83HT8
- GeneID:   1064250
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW406
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   CLSK229722
- BioCyc:   TWHI218496:TW0384-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 21895; Mature: 21895

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLFDLWTDLLDLLTIVAGPTAVGKGTVISHLRKCHPQVKVSISATTREPRDSERDGIDY
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEE
YFVTDEVFDCMVRSGQMLEWATVHGLHKYGTPKEEVERLLHTGQPVILEIDLQGMRKVRK
EEEHHHHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHH
ILPAVRTVILLPPAWDDLICRIKRRGSESQDEIDARLATAKKELEAIGEFDYKIVNADVE
HHHHHHHHEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCE
IAANELWLAMNRV
EHHHHHHHEECCC
>Mature Secondary Structure
MQLFDLWTDLLDLLTIVAGPTAVGKGTVISHLRKCHPQVKVSISATTREPRDSERDGIDY
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEE
YFVTDEVFDCMVRSGQMLEWATVHGLHKYGTPKEEVERLLHTGQPVILEIDLQGMRKVRK
EEEHHHHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECHHHHHHHHH
ILPAVRTVILLPPAWDDLICRIKRRGSESQDEIDARLATAKKELEAIGEFDYKIVNADVE
HHHHHHHHEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCE
IAANELWLAMNRV
EHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174