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The map label for this gene is comEC [H]

Identifier: 28572541

GI number: 28572541

Start: 422606

End: 423442

Strand: Direct

Name: comEC [H]

Synonym: TW388

Alternate gene names: 28572541

Gene position: 422606-423442 (Clockwise)

Preceding gene: 28572540

Following gene: 28572542

Centisome position: 45.64

GC content: 43.61

Gene sequence:

>837_bases
ATGAAGAAATATCGTTTGGCTATTGCACTATCAGCTGTTCTCTCAGCAATTTTTGTGTATTTTGCTGCGTTTACAGGAGG
GCAAAATTGGGTCGTAGCTGTGTGTGACGTAGGTCAAGGCGATGCGGTTATGATTCGCAGTAACTCGAGTATTGCCATGG
TAGATATGGGTGCAAGTGAAAAGTTACTCGATAAGTGTATGAAAAGATTTTCTGTTCAAAGGATTAATCTTCTTGTTATA
AGCCACTATGACCGTGACCATGTTGGAGGATACAAGAGCGTTGTTGGGAAGGTTGACAGGGTGCTTACCGGTGAAAATGA
TCGGCTCTTGGCAAGTGTTATAGAAAGCACCCTTGTAAAGGGTGGGGCCAGTATGTCACGCGTACATAAAGGGGATACCG
GACTCCTTGGTCAGATGAAATGGGAAATTATTTGGCCCCGGAGAGATAATCCGCCAAACTTACGCCGTGGTAATAACGGA
AGCGTAGTTATAGCCTTTCGGGGAGATAAGCTGAGCATGATATTTTTGGGCGATCTTGGCAAGCCGGCACAGCAGTTAAT
TTTTAGTGATTTTACAAACACTACGCACGGTGCATACGACATAGTCAAGGTTGCCCACCACGGTTCATCTGATCAATTTC
CTATGCTTTACAAGCATATCTCTGCTAAATATGGGATTATTTCTGCGGGGAAGCAGAATCGATATGGGCACCCAACGAAA
ATCGCTCTTGAAATACTTCGAAAGTATGGTACGCAACCCCTGGTTACGTCTGTTTCAGGTTATATTTCCATTTCTGGTAA
CAGGGATAATTTTGAGATTCATAAGGAGCATGACTAA

Upstream 100 bases:

>100_bases
GTGTTCTGGGCGTTATGCTCCTGATCACTCTAACATTGAGCATTATTTTTGTCGTTAGAAGATTGACGGGCACGACAGTG
CCCATGCAAAAGAGCAAAGT

Downstream 100 bases:

>100_bases
TATCCATGGCATGTGGTTACTTGAAACATCGACTGATAGTGTGCTTGGCGGTATCAGTCTATGAGTATTGACCCTCTTGT
TTTGTTATCAGGTAAATGCG

Product: DNA uptake protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKKYRLAIALSAVLSAIFVYFAAFTGGQNWVVAVCDVGQGDAVMIRSNSSIAMVDMGASEKLLDKCMKRFSVQRINLLVI
SHYDRDHVGGYKSVVGKVDRVLTGENDRLLASVIESTLVKGGASMSRVHKGDTGLLGQMKWEIIWPRRDNPPNLRRGNNG
SVVIAFRGDKLSMIFLGDLGKPAQQLIFSDFTNTTHGAYDIVKVAHHGSSDQFPMLYKHISAKYGIISAGKQNRYGHPTK
IALEILRKYGTQPLVTSVSGYISISGNRDNFEIHKEHD

Sequences:

>Translated_278_residues
MKKYRLAIALSAVLSAIFVYFAAFTGGQNWVVAVCDVGQGDAVMIRSNSSIAMVDMGASEKLLDKCMKRFSVQRINLLVI
SHYDRDHVGGYKSVVGKVDRVLTGENDRLLASVIESTLVKGGASMSRVHKGDTGLLGQMKWEIIWPRRDNPPNLRRGNNG
SVVIAFRGDKLSMIFLGDLGKPAQQLIFSDFTNTTHGAYDIVKVAHHGSSDQFPMLYKHISAKYGIISAGKQNRYGHPTK
IALEILRKYGTQPLVTSVSGYISISGNRDNFEIHKEHD
>Mature_278_residues
MKKYRLAIALSAVLSAIFVYFAAFTGGQNWVVAVCDVGQGDAVMIRSNSSIAMVDMGASEKLLDKCMKRFSVQRINLLVI
SHYDRDHVGGYKSVVGKVDRVLTGENDRLLASVIESTLVKGGASMSRVHKGDTGLLGQMKWEIIWPRRDNPPNLRRGNNG
SVVIAFRGDKLSMIFLGDLGKPAQQLIFSDFTNTTHGAYDIVKVAHHGSSDQFPMLYKHISAKYGIISAGKQNRYGHPTK
IALEILRKYGTQPLVTSVSGYISISGNRDNFEIHKEHD

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 30673; Mature: 30673

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYRLAIALSAVLSAIFVYFAAFTGGQNWVVAVCDVGQGDAVMIRSNSSIAMVDMGASE
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCH
KLLDKCMKRFSVQRINLLVISHYDRDHVGGYKSVVGKVDRVLTGENDRLLASVIESTLVK
HHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GGASMSRVHKGDTGLLGQMKWEIIWPRRDNPPNLRRGNNGSVVIAFRGDKLSMIFLGDLG
CCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEEEEEEECCC
KPAQQLIFSDFTNTTHGAYDIVKVAHHGSSDQFPMLYKHISAKYGIISAGKQNRYGHPTK
CHHHHHHHHHCCCCCCCHHHEEHEEECCCCCCCHHHHHHHCCCCCEEECCCCCCCCCHHH
IALEILRKYGTQPLVTSVSGYISISGNRDNFEIHKEHD
HHHHHHHHHCCCCEEEECCEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MKKYRLAIALSAVLSAIFVYFAAFTGGQNWVVAVCDVGQGDAVMIRSNSSIAMVDMGASE
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCH
KLLDKCMKRFSVQRINLLVISHYDRDHVGGYKSVVGKVDRVLTGENDRLLASVIESTLVK
HHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GGASMSRVHKGDTGLLGQMKWEIIWPRRDNPPNLRRGNNGSVVIAFRGDKLSMIFLGDLG
CCCHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEEEEEEECCC
KPAQQLIFSDFTNTTHGAYDIVKVAHHGSSDQFPMLYKHISAKYGIISAGKQNRYGHPTK
CHHHHHHHHHCCCCCCCHHHEEHEEECCCCCCCHHHHHHHCCCCCEEECCCCCCCCCHHH
IALEILRKYGTQPLVTSVSGYISISGNRDNFEIHKEHD
HHHHHHHHHCCCCEEEECCEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]