Click here to switch to the map view.

The map label for this gene is comEA [H]

Identifier: 28572539

GI number: 28572539

Start: 420613

End: 421194

Strand: Direct

Name: comEA [H]

Synonym: TW386

Alternate gene names: 28572539

Gene position: 420613-421194 (Clockwise)

Preceding gene: 28572538

Following gene: 28572540

Centisome position: 45.43

GC content: 40.89

Gene sequence:

>582_bases
ATGCACAAGTTTCGCTGGACCCTTTCTGCGGCGACTTCTTGGTCCTTCGTTATCTCTTTGGTACTAGCGTCGGGCCTGCT
CATTCTGGTTTATACAAAACCTTTTTTTGGCCCTGATAAGAATTCTAAAAATGTTTCATTTGATGCTATTGAAAGTCCTG
CACATACCAGTTTTACAGCCACATCCTCTGGAATGAATATGATTAGCGTTCATGTAGCCGGTGAAATCGTTCATCCCGGA
GTCTACTCTCTTGAAGCTGGCTCACGCGTAAATAACGCAATTATTGCTGCAGGTGGATTCAAACCGCTTTCTGATACTAA
TTCAGTAAATCTTGCAGAATTACTCCGTGATGGGCAAAAAATTGTTGTTCTTCCAAAAGACAGTGAATCTTCGCCTGTAA
ATATAAACACTGCGGATGCCCAGAGATTGCAGTCAATAAAGGGAATAGGAAAGGCTACAGCTAAAAGAATTATTGATTGG
CGCAACAAACACGGACCCTTCAAAAGGCTGGAGGATCTGAAAAAAATATCTGGTATAGGTAACAAACTTATCAAGAGCAT
AAAAGACAAGGTTATACTTTGA

Upstream 100 bases:

>100_bases
CGTTGTGGAGCCCAAATAGATCGTGCTGCAAGCTAGGTAAGTTTTACACAGTTTTTGCTTTTTCATTTGTTCATAGGGTG
TAGCAAAATATCTTTTCTCT

Downstream 100 bases:

>100_bases
CAGATTTTCGTGCTGTGCCCTTAGCTTTATCGGCCTGGACTACATCTGTTTTGTTGGTGCAACACGTTAGGCTGTGGTTC
CTCGTATTTGCCCTTTTCGT

Product: DNA uptake protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MHKFRWTLSAATSWSFVISLVLASGLLILVYTKPFFGPDKNSKNVSFDAIESPAHTSFTATSSGMNMISVHVAGEIVHPG
VYSLEAGSRVNNAIIAAGGFKPLSDTNSVNLAELLRDGQKIVVLPKDSESSPVNINTADAQRLQSIKGIGKATAKRIIDW
RNKHGPFKRLEDLKKISGIGNKLIKSIKDKVIL

Sequences:

>Translated_193_residues
MHKFRWTLSAATSWSFVISLVLASGLLILVYTKPFFGPDKNSKNVSFDAIESPAHTSFTATSSGMNMISVHVAGEIVHPG
VYSLEAGSRVNNAIIAAGGFKPLSDTNSVNLAELLRDGQKIVVLPKDSESSPVNINTADAQRLQSIKGIGKATAKRIIDW
RNKHGPFKRLEDLKKISGIGNKLIKSIKDKVIL
>Mature_193_residues
MHKFRWTLSAATSWSFVISLVLASGLLILVYTKPFFGPDKNSKNVSFDAIESPAHTSFTATSSGMNMISVHVAGEIVHPG
VYSLEAGSRVNNAIIAAGGFKPLSDTNSVNLAELLRDGQKIVVLPKDSESSPVNINTADAQRLQSIKGIGKATAKRIIDW
RNKHGPFKRLEDLKKISGIGNKLIKSIKDKVIL

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 20897; Mature: 20897

Theoretical pI: Translated: 10.64; Mature: 10.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKFRWTLSAATSWSFVISLVLASGLLILVYTKPFFGPDKNSKNVSFDAIESPAHTSFTA
CCCEEEEEECHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCEEEE
TSSGMNMISVHVAGEIVHPGVYSLEAGSRVNNAIIAAGGFKPLSDTNSVNLAELLRDGQK
CCCCCEEEEEEEECEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCE
IVVLPKDSESSPVNINTADAQRLQSIKGIGKATAKRIIDWRNKHGPFKRLEDLKKISGIG
EEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NKLIKSIKDKVIL
HHHHHHHHHHCCC
>Mature Secondary Structure
MHKFRWTLSAATSWSFVISLVLASGLLILVYTKPFFGPDKNSKNVSFDAIESPAHTSFTA
CCCEEEEEECHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCCEEEE
TSSGMNMISVHVAGEIVHPGVYSLEAGSRVNNAIIAAGGFKPLSDTNSVNLAELLRDGQK
CCCCCEEEEEEEECEEECCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHCCCE
IVVLPKDSESSPVNINTADAQRLQSIKGIGKATAKRIIDWRNKHGPFKRLEDLKKISGIG
EEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
NKLIKSIKDKVIL
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]