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The map label for this gene is orn

Identifier: 28572517

GI number: 28572517

Start: 396883

End: 397437

Strand: Direct

Name: orn

Synonym: TW364

Alternate gene names: 28572517

Gene position: 396883-397437 (Clockwise)

Preceding gene: 28572515

Following gene: 28572518

Centisome position: 42.86

GC content: 47.39

Gene sequence:

>555_bases
ATGTGTGTGGCTCCGACTCCCTCGCATCTCGTATGGGTTGACTGTGAAATGACAGGTCTGAATCCAGAGCGTGACGAGCT
TTTGGAAGTCGCGGTCATTGTAACTGACAAGGATCTCCTCCCTCTGGACGAGGGGGTTAATGTTGTTGTGTCACCTTCCT
CAGAAGCTCTTGGTGCGATGGATAACTATGTTGCGCGCATGCATAGAGTATCCGGTTTGCTTGATGAGCTCTCTAATGGG
GTTCCTGTTTCTGAAGCCCAGGCAATGGTCAAGGAATACATAACAAAGCACATAAAAACCGGTGGGATTATGTCTGGTAA
CAGTATCGCAACCGACAGGTTATTCATTACACGCTATATGCCCGATGTGCACGCTATTCTTCATTACCGAATGATTGATG
TTTCGAGTATAAAGGAATTGGCTGTCAGATGGGCACCCGAGATATACAGTGGCGCGCCCAATAAAAAGGGTGGACATAGG
GCAATGGCTGATGTTCTAGAATCAATCGCTGAACTTGCATACTATCGCGAACATTTCCTAACTGGTACTGCGTGA

Upstream 100 bases:

>100_bases
AAACTGCGGCCAGACCAGAACATTCCACGCAGCATTCACCATGAGAATTGAGGGTAACAGGTAACCCATACCGTAATTAT
ATCCAACCGGCGCTACACTT

Downstream 100 bases:

>100_bases
AAGGCTGGCGATTCGCGGTATGATCGTTCTGCATTTATCTTGGTGGATATAGCTCAGCTGGTAGAGCACCTGGTTGTGGT
CCAGGATGTCGCGGGTTCGA

Product: oligoribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MCVAPTPSHLVWVDCEMTGLNPERDELLEVAVIVTDKDLLPLDEGVNVVVSPSSEALGAMDNYVARMHRVSGLLDELSNG
VPVSEAQAMVKEYITKHIKTGGIMSGNSIATDRLFITRYMPDVHAILHYRMIDVSSIKELAVRWAPEIYSGAPNKKGGHR
AMADVLESIAELAYYREHFLTGTA

Sequences:

>Translated_184_residues
MCVAPTPSHLVWVDCEMTGLNPERDELLEVAVIVTDKDLLPLDEGVNVVVSPSSEALGAMDNYVARMHRVSGLLDELSNG
VPVSEAQAMVKEYITKHIKTGGIMSGNSIATDRLFITRYMPDVHAILHYRMIDVSSIKELAVRWAPEIYSGAPNKKGGHR
AMADVLESIAELAYYREHFLTGTA
>Mature_184_residues
MCVAPTPSHLVWVDCEMTGLNPERDELLEVAVIVTDKDLLPLDEGVNVVVSPSSEALGAMDNYVARMHRVSGLLDELSNG
VPVSEAQAMVKEYITKHIKTGGIMSGNSIATDRLFITRYMPDVHAILHYRMIDVSSIKELAVRWAPEIYSGAPNKKGGHR
AMADVLESIAELAYYREHFLTGTA

Specific function: 3'-to-5' exoribonuclease specific for small oligoribonucleotides

COG id: COG1949

COG function: function code A; Oligoribonuclease (3'->5' exoribonuclease)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain

Homologues:

Organism=Homo sapiens, GI224496106, Length=175, Percent_Identity=38.8571428571429, Blast_Score=139, Evalue=1e-33,
Organism=Escherichia coli, GI87082382, Length=180, Percent_Identity=45, Blast_Score=165, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17557752, Length=178, Percent_Identity=39.8876404494382, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6323088, Length=181, Percent_Identity=36.4640883977901, Blast_Score=118, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21355135, Length=173, Percent_Identity=46.242774566474, Blast_Score=155, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ORN_TROW8 (Q83HW9)

Other databases:

- EMBL:   BX251411
- RefSeq:   NP_789297.1
- ProteinModelPortal:   Q83HW9
- SMR:   Q83HW9
- STRING:   Q83HW9
- GeneID:   1064650
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW364
- eggNOG:   COG1949
- HOGENOM:   HBG448545
- OMA:   ARRWYPR
- PhylomeDB:   Q83HW9
- ProtClustDB:   PRK05359
- BioCyc:   TWHI218496:TW0342-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00045
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR022894
- InterPro:   IPR012337
- SMART:   SM00479

Pfam domain/function: PF00929 Exonuc_X-T; SSF53098 RNaseH_fold

EC number: 3.1.-.- [C]

Molecular weight: Translated: 20224; Mature: 20224

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCVAPTPSHLVWVDCEMTGLNPERDELLEVAVIVTDKDLLPLDEGVNVVVSPSSEALGAM
CCCCCCCCCEEEEEEEECCCCCCHHHHHEEEEEEECCCCCCCCCCCEEEECCCHHHHHHH
DNYVARMHRVSGLLDELSNGVPVSEAQAMVKEYITKHIKTGGIMSGNSIATDRLFITRYM
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
PDVHAILHYRMIDVSSIKELAVRWAPEIYSGAPNKKGGHRAMADVLESIAELAYYREHFL
CHHHHHHHHHHHCHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TGTA
CCCC
>Mature Secondary Structure
MCVAPTPSHLVWVDCEMTGLNPERDELLEVAVIVTDKDLLPLDEGVNVVVSPSSEALGAM
CCCCCCCCCEEEEEEEECCCCCCHHHHHEEEEEEECCCCCCCCCCCEEEECCCHHHHHHH
DNYVARMHRVSGLLDELSNGVPVSEAQAMVKEYITKHIKTGGIMSGNSIATDRLFITRYM
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
PDVHAILHYRMIDVSSIKELAVRWAPEIYSGAPNKKGGHRAMADVLESIAELAYYREHFL
CHHHHHHHHHHHCHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TGTA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174