Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 28572266

GI number: 28572266

Start: 98907

End: 100013

Strand: Reverse

Name: dxr

Synonym: TW099

Alternate gene names: 28572266

Gene position: 100013-98907 (Counterclockwise)

Preceding gene: 28572268

Following gene: 28572264

Centisome position: 10.8

GC content: 46.79

Gene sequence:

>1107_bases
GTGCAGAGGGTAATAATTGTTGGCTCAACCGGATCTATAGGAACACAAGCGATTGACTTTATCTTAAAAAATCGCGATAG
TTTTCTGGTTGTAGGGCTCGCTGCGAGCACGCAAACAAGTCTTCTTCGAGAGCAAGCGCAAGTATTTGGCACGAAAAACA
CAGCACAGGGTGCGAGCGAAGCGGCAGAGCTTATAGAAGCTACCGAGGCGGATGTTGTGCTAAACGCCATAACCGGCGCG
GCTGGATTATTATCTACATACGCTACGCTCAAGACCGGCAAACGGCTTGCGCTGGCGAACAAAGAATCATTGATTATGGG
CGGGAAATATTTCCTAGACATGACAAGCTTCAAAGGTCAAATAACGCCGGTTGATTCAGAGCATTCTGCGATAGCGCAGG
CCATGAAGTCCGGAAAATTCTCCGAGGTAAATAAGCTCATCCTGACAGCTTCGGGTGGGCCTTTTTATGACAGGGAAAGC
CTGGAGGGTATAACTCTTAAAGATGCCCTAGACCATCCCACATGGAATATGGGACCCATGATAAGTATAAATTCCGCAAC
AATGTTCAATAAGGGTCTTGAGATTATTGAAGCGCATCTACTATTTGGTATTCCGTACTCGCAAATCGATGTTGTGATTC
ACCCACAATCAATTGTTCATTCAATGGTCGAGTATAAAGACGGATCTGTTATTGCACAGGCCTCTGTTGCAGATATGACC
CTGCCAATAGGGTATGCCCTGAGTTGGCCTAACCGAGCTTTAAATGCGGTTAGACCACTTGAGTGGGGTGCAAGGCAGAG
GTGGGACTTCCTGCCACCAACAGAAAACTCAATGAGGAGTATCAATCTCGCACGGCGAGCCGGTGAAGCCGGAGGGGTTT
ATCCCGCTGTCCTGAATGCCAGCAATGAATGTGCAGTAGAGGCATTTATGGCTGGCAAAATATCCTTTGCAAGGATAATC
CATGTAACAGAAACGGTTTTTAACCTCTATACAAAACAACATACGAACCGCGAGTCGGCGAAAAATCCAATTGAGGTCAT
TTTAGAAGAGGATGCCCGAACCAGAGAGCTAGCCAAAACAGTTATAGAGAATATGAGCGCTGACTGA

Upstream 100 bases:

>100_bases
ACTTGCCAGAGACGATGTAATCATCTGAACCAGTTGATCTATTAGACACAGCCCTTAACAAGTCTTATGCGGATACGAAA
ATTGTACTAGAGTTTCAAGT

Downstream 100 bases:

>100_bases
GCTAACCAAGACGAAGCGGGTTTACTATATCTATCCAGGCGAGCATAATACTCATCACAATAATCGCGGCTGTTACAAGC
AGTGTAACAGGTAACAAATA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MQRVIIVGSTGSIGTQAIDFILKNRDSFLVVGLAASTQTSLLREQAQVFGTKNTAQGASEAAELIEATEADVVLNAITGA
AGLLSTYATLKTGKRLALANKESLIMGGKYFLDMTSFKGQITPVDSEHSAIAQAMKSGKFSEVNKLILTASGGPFYDRES
LEGITLKDALDHPTWNMGPMISINSATMFNKGLEIIEAHLLFGIPYSQIDVVIHPQSIVHSMVEYKDGSVIAQASVADMT
LPIGYALSWPNRALNAVRPLEWGARQRWDFLPPTENSMRSINLARRAGEAGGVYPAVLNASNECAVEAFMAGKISFARII
HVTETVFNLYTKQHTNRESAKNPIEVILEEDARTRELAKTVIENMSAD

Sequences:

>Translated_368_residues
MQRVIIVGSTGSIGTQAIDFILKNRDSFLVVGLAASTQTSLLREQAQVFGTKNTAQGASEAAELIEATEADVVLNAITGA
AGLLSTYATLKTGKRLALANKESLIMGGKYFLDMTSFKGQITPVDSEHSAIAQAMKSGKFSEVNKLILTASGGPFYDRES
LEGITLKDALDHPTWNMGPMISINSATMFNKGLEIIEAHLLFGIPYSQIDVVIHPQSIVHSMVEYKDGSVIAQASVADMT
LPIGYALSWPNRALNAVRPLEWGARQRWDFLPPTENSMRSINLARRAGEAGGVYPAVLNASNECAVEAFMAGKISFARII
HVTETVFNLYTKQHTNRESAKNPIEVILEEDARTRELAKTVIENMSAD
>Mature_368_residues
MQRVIIVGSTGSIGTQAIDFILKNRDSFLVVGLAASTQTSLLREQAQVFGTKNTAQGASEAAELIEATEADVVLNAITGA
AGLLSTYATLKTGKRLALANKESLIMGGKYFLDMTSFKGQITPVDSEHSAIAQAMKSGKFSEVNKLILTASGGPFYDRES
LEGITLKDALDHPTWNMGPMISINSATMFNKGLEIIEAHLLFGIPYSQIDVVIHPQSIVHSMVEYKDGSVIAQASVADMT
LPIGYALSWPNRALNAVRPLEWGARQRWDFLPPTENSMRSINLARRAGEAGGVYPAVLNASNECAVEAFMAGKISFARII
HVTETVFNLYTKQHTNRESAKNPIEVILEEDARTRELAKTVIENMSAD

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=404, Percent_Identity=36.1386138613861, Blast_Score=232, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_TROW8 (Q83IC8)

Other databases:

- EMBL:   BX251410
- RefSeq:   NP_789046.1
- ProteinModelPortal:   Q83IC8
- SMR:   Q83IC8
- STRING:   Q83IC8
- GeneID:   1064329
- GenomeReviews:   BX072543_GR
- KEGG:   tws:TW099
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q83IC8
- ProtClustDB:   PRK05447
- BioCyc:   TWHI218496:TW0091-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 39894; Mature: 39894

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: BINDING 101-101 BINDING 127-127 BINDING 151-151 BINDING 172-172 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRVIIVGSTGSIGTQAIDFILKNRDSFLVVGLAASTQTSLLREQAQVFGTKNTAQGASE
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHH
AAELIEATEADVVLNAITGAAGLLSTYATLKTGKRLALANKESLIMGGKYFLDMTSFKGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCEEEEEECCCCE
ITPVDSEHSAIAQAMKSGKFSEVNKLILTASGGPFYDRESLEGITLKDALDHPTWNMGPM
ECCCCCHHHHHHHHHHCCCHHHCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCE
ISINSATMFNKGLEIIEAHLLFGIPYSQIDVVIHPQSIVHSMVEYKDGSVIAQASVADMT
EEECCHHHHHHHHHHHHHHHHHCCCHHHEEEEECCHHHHHHHHHCCCCCEEEEECHHHEE
LPIGYALSWPNRALNAVRPLEWGARQRWDFLPPTENSMRSINLARRAGEAGGVYPAVLNA
ECCCEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHEECC
SNECAVEAFMAGKISFARIIHVTETVFNLYTKQHTNRESAKNPIEVILEEDARTRELAKT
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCHHHHHHHH
VIENMSAD
HHHHCCCC
>Mature Secondary Structure
MQRVIIVGSTGSIGTQAIDFILKNRDSFLVVGLAASTQTSLLREQAQVFGTKNTAQGASE
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCHHH
AAELIEATEADVVLNAITGAAGLLSTYATLKTGKRLALANKESLIMGGKYFLDMTSFKGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEECCCEEEEEECCCCE
ITPVDSEHSAIAQAMKSGKFSEVNKLILTASGGPFYDRESLEGITLKDALDHPTWNMGPM
ECCCCCHHHHHHHHHHCCCHHHCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCE
ISINSATMFNKGLEIIEAHLLFGIPYSQIDVVIHPQSIVHSMVEYKDGSVIAQASVADMT
EEECCHHHHHHHHHHHHHHHHHCCCHHHEEEEECCHHHHHHHHHCCCCCEEEEECHHHEE
LPIGYALSWPNRALNAVRPLEWGARQRWDFLPPTENSMRSINLARRAGEAGGVYPAVLNA
ECCCEEECCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHEECC
SNECAVEAFMAGKISFARIIHVTETVFNLYTKQHTNRESAKNPIEVILEEDARTRELAKT
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCHHHHHHHH
VIENMSAD
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174