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The map label for this gene is mprA [H]

Identifier: 28572226

GI number: 28572226

Start: 46318

End: 47001

Strand: Reverse

Name: mprA [H]

Synonym: TW055

Alternate gene names: 28572226

Gene position: 47001-46318 (Counterclockwise)

Preceding gene: 28572232

Following gene: 28572225

Centisome position: 5.08

GC content: 47.66

Gene sequence:

>684_bases
ATGAGTCAGACAAAGATTCTAGTTGTTGACGACGAAGCCAATATACGGGATCTCCTGGCGGCGAGCTTGCGGTTCGCGGG
GTACGGTGTGGTCACCGCTGGGAATGGCGCCGGTGCAGTCTCGGCGGTCCTGGCTGAGGAGCCAGACCTGATAATCATGG
ATGTTATGCTCCCAGATATGAGCGGGTTTGCTGCAACGAAACGACTTCGCGAGGCTGGTTTTCGCTGTCCCGTGATATTC
CTGAGTGCAAGAGATAGCACAGAAGACAAGATAACTGGCCTCACCGTAGGTGGTGATGATTACGTTACAAAACCATTTAG
TCTCGATGAGATACTGGCGCGTGTGGCAGCTATTCTGCGTCGAACAAAGATAGATGATGTAGACGCAACTATCCGTGTTG
GTGACCTAGTAATCGATCAAAACTCAAATGAGGTGTTCCTAAAGGGTAACCTAATTGATCTCAGTCCAACTGAGTTCAAA
CTTCTGCGGTACTTTATGTTGAATCCAAACCGCGTGCTTTCAAAGTCTCAAATACTGGGGCACGTTTGGGACTATGATTT
TGATGGTGACTCGAGTATTGTCGAGTCCTATATTTCGTATATAAGACGCAAGTTAGCAGCTTACAGTAGCGAAACGATTA
TTCATACCAAGCGAGGTTTTGGTTATATCATGAGAACGCGCTGA

Upstream 100 bases:

>100_bases
GTTCCTGGCGGTTTGCTCGGGGTATCCCTTGTTGGAGTTGGTCCGAATCGTTGCACCAGCGATATTCGGTAATAGTGCGC
TACACGCAGGGTCTAAGTTC

Downstream 100 bases:

>100_bases
CTCGTGTCAGCAAAGTTTCCCAGTAAGCTGTACAGACTCGTTGCACGCTCTTCGATAAAGAGTAAGGTGGTAACGCTTGT
AGCGCTTGTGCTTGCATTTT

Product: two component system response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSQTKILVVDDEANIRDLLAASLRFAGYGVVTAGNGAGAVSAVLAEEPDLIIMDVMLPDMSGFAATKRLREAGFRCPVIF
LSARDSTEDKITGLTVGGDDYVTKPFSLDEILARVAAILRRTKIDDVDATIRVGDLVIDQNSNEVFLKGNLIDLSPTEFK
LLRYFMLNPNRVLSKSQILGHVWDYDFDGDSSIVESYISYIRRKLAAYSSETIIHTKRGFGYIMRTR

Sequences:

>Translated_227_residues
MSQTKILVVDDEANIRDLLAASLRFAGYGVVTAGNGAGAVSAVLAEEPDLIIMDVMLPDMSGFAATKRLREAGFRCPVIF
LSARDSTEDKITGLTVGGDDYVTKPFSLDEILARVAAILRRTKIDDVDATIRVGDLVIDQNSNEVFLKGNLIDLSPTEFK
LLRYFMLNPNRVLSKSQILGHVWDYDFDGDSSIVESYISYIRRKLAAYSSETIIHTKRGFGYIMRTR
>Mature_226_residues
SQTKILVVDDEANIRDLLAASLRFAGYGVVTAGNGAGAVSAVLAEEPDLIIMDVMLPDMSGFAATKRLREAGFRCPVIFL
SARDSTEDKITGLTVGGDDYVTKPFSLDEILARVAAILRRTKIDDVDATIRVGDLVIDQNSNEVFLKGNLIDLSPTEFKL
LRYFMLNPNRVLSKSQILGHVWDYDFDGDSSIVESYISYIRRKLAAYSSETIIHTKRGFGYIMRTR

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=39.5555555555556, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=35.9090909090909, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=34.3612334801762, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=34.8214285714286, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=34.0909090909091, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=34.4036697247706, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=31.3636363636364, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=29.5964125560538, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32.4444444444444, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=29.646017699115, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=33.6244541484716, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=30.6034482758621, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.5154185022026, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=37.962962962963, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=33.0434782608696, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=38.6792452830189, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788713, Length=130, Percent_Identity=33.8461538461538, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=169, Percent_Identity=26.6272189349112, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25152; Mature: 25021

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTKILVVDDEANIRDLLAASLRFAGYGVVTAGNGAGAVSAVLAEEPDLIIMDVMLPDM
CCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCCCCCEEEEEEECCCC
SGFAATKRLREAGFRCPVIFLSARDSTEDKITGLTVGGDDYVTKPFSLDEILARVAAILR
CCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHH
RTKIDDVDATIRVGDLVIDQNSNEVFLKGNLIDLSPTEFKLLRYFMLNPNRVLSKSQILG
HCCCCCCCCEEEEEEEEEECCCCEEEEECCEEECCCHHHHHHHHHHCCCHHHHHHHHHHH
HVWDYDFDGDSSIVESYISYIRRKLAAYSSETIIHTKRGFGYIMRTR
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECC
>Mature Secondary Structure 
SQTKILVVDDEANIRDLLAASLRFAGYGVVTAGNGAGAVSAVLAEEPDLIIMDVMLPDM
CCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCCCCCEEEEEEECCCC
SGFAATKRLREAGFRCPVIFLSARDSTEDKITGLTVGGDDYVTKPFSLDEILARVAAILR
CCHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCEECCCCHHHHHHHHHHHHH
RTKIDDVDATIRVGDLVIDQNSNEVFLKGNLIDLSPTEFKLLRYFMLNPNRVLSKSQILG
HCCCCCCCCEEEEEEEEEECCCCEEEEECCEEECCCHHHHHHHHHHCCCHHHHHHHHHHH
HVWDYDFDGDSSIVESYISYIRRKLAAYSSETIIHTKRGFGYIMRTR
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA