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The map label for this gene is trpE [H]

Identifier: 28378344

GI number: 28378344

Start: 1506783

End: 1508219

Strand: Direct

Name: trpE [H]

Synonym: lp_1652

Alternate gene names: 28378344

Gene position: 1506783-1508219 (Clockwise)

Preceding gene: 28378343

Following gene: 28378345

Centisome position: 45.55

GC content: 46.83

Gene sequence:

>1437_bases
ATGAATCCAACATTACCAACCTTGATTCCTTATCAGGATCATTATCCCTACGTACCAGTGATGGTCAAACGACCACTCGC
CACATTTGACCCCATTGCGGTTGCTAAAATTGTCCACCAGATGGGGAACGGTTTCGCGCTGACGATTGATCGGCACCAAC
GATATAGCTATTTTAGTTTTAAACCACAGCGAAGTCTCACGGGTCGGCAACTAGCCAAGCACAAACGACCAGCTAATGAG
ACACTCCAAGCCATTCTAAACCAATATCGAACACCACGAATTCAAGGATTACCACCATTTACGGGGGGCTTGATAGGGTA
CTTCGGCTATGAGTATATTCAACAATTTGTACTCAAGTTGCATTTGAAATCACCAGCAACCGCAGATCTCGATGACTTAG
GTTTATTCTTAGTTACGAGTGTGCTCGTCTATGATCATCGACATCATGAGCTTGGGTTGACGCAGCTGATTTCAACTGCG
GATTTAGCGGCAACTTACGCCGTGACTCAAACGGCTCTAACGCAACAGTTAGCCGCCATTATTGAACAATTACAGCAACC
AATAGCTCTGCCACCATTTGACTTACAGCAACCATTACACATGCAAGCGGATCAAGCGACCTATGCGCGTCAGGTTGACC
GAATTCGCCAACACATCTACGCTGGTGATATTTTCCAAATGATATATGCTAATCCATGTTTGGGGACCATGAGCGGGTCA
TTGCTGGCAGTTTATCAGCAACTTCAAAAAACAGCGGCCCCGTATACCTGTTATTTTAAACAGGCTAATTTCGAAATGAC
GGTGGCCTCACCAGAAACGTTAGTGACGAAGGATGGGGAACAAATCGCGACGTATCCATTGGCCGGGACGAGACGCCGTG
GTCGAACACCTGCCGAGGATCAGCAGTTGGCTCATGAATTACAAACCAGCCCTAAAGAGATTGCCGAGCACAATATGTTA
GTTGATTTGGGACGTAACGATTTAGGACAAGTTGCAAAGTTTAAAAGTGTCCGAGTGACTAATTTACGGCGATTAATTCG
TTATTCGCAAGTCATGCACTTAGGGTCTCGGGTGGCCGCAGAAGTGGCGCCGACTACTACAGCACTCCAAGTGCTTGCCG
CTACTTTTCCAGCTGGGACGTTAGCTGGCGCGCCTAAGATTGAAGCAATGACCCTGATTAATCATTATGAGCAGGTGCCG
CGGGGTGCTTATGGTGGTTGCTTTGGTTACTTGGATTGTAACGGTAATTTAGACATGGCGATTGGCATCCGGCTGGCCTA
CCGAATGAATGAACAGTTGGTGATTCCAGCGGGTGCGGGCATTGTTGCTGACAGTATCGGCGCTCAAGAATTTAAGGAGT
GCCAGAATAAACAACGAGTGATCGTTAATGCAGTACAAGACGCGAAAGGACGAGTTAAAGATGGAATTATTAATTGA

Upstream 100 bases:

>100_bases
CATGGACGGATTTTTTTGATAGGGGGCAGTTCAATGCAGCAACGATGGCAATTAACCACAACTCAAGTAAAACTATCTTA
TTAATGAGGAGTGGTTCAGT

Downstream 100 bases:

>100_bases
TAACTATGACAGCTTTACTTATAACTTGTATCAACTAATTGGTCGTCTGACGCCCGATGTACGGGTCATTAAAAATGACG
ATTTGACGGTTGCTGCAATC

Product: anthranilate synthase, component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MNPTLPTLIPYQDHYPYVPVMVKRPLATFDPIAVAKIVHQMGNGFALTIDRHQRYSYFSFKPQRSLTGRQLAKHKRPANE
TLQAILNQYRTPRIQGLPPFTGGLIGYFGYEYIQQFVLKLHLKSPATADLDDLGLFLVTSVLVYDHRHHELGLTQLISTA
DLAATYAVTQTALTQQLAAIIEQLQQPIALPPFDLQQPLHMQADQATYARQVDRIRQHIYAGDIFQMIYANPCLGTMSGS
LLAVYQQLQKTAAPYTCYFKQANFEMTVASPETLVTKDGEQIATYPLAGTRRRGRTPAEDQQLAHELQTSPKEIAEHNML
VDLGRNDLGQVAKFKSVRVTNLRRLIRYSQVMHLGSRVAAEVAPTTTALQVLAATFPAGTLAGAPKIEAMTLINHYEQVP
RGAYGGCFGYLDCNGNLDMAIGIRLAYRMNEQLVIPAGAGIVADSIGAQEFKECQNKQRVIVNAVQDAKGRVKDGIIN

Sequences:

>Translated_478_residues
MNPTLPTLIPYQDHYPYVPVMVKRPLATFDPIAVAKIVHQMGNGFALTIDRHQRYSYFSFKPQRSLTGRQLAKHKRPANE
TLQAILNQYRTPRIQGLPPFTGGLIGYFGYEYIQQFVLKLHLKSPATADLDDLGLFLVTSVLVYDHRHHELGLTQLISTA
DLAATYAVTQTALTQQLAAIIEQLQQPIALPPFDLQQPLHMQADQATYARQVDRIRQHIYAGDIFQMIYANPCLGTMSGS
LLAVYQQLQKTAAPYTCYFKQANFEMTVASPETLVTKDGEQIATYPLAGTRRRGRTPAEDQQLAHELQTSPKEIAEHNML
VDLGRNDLGQVAKFKSVRVTNLRRLIRYSQVMHLGSRVAAEVAPTTTALQVLAATFPAGTLAGAPKIEAMTLINHYEQVP
RGAYGGCFGYLDCNGNLDMAIGIRLAYRMNEQLVIPAGAGIVADSIGAQEFKECQNKQRVIVNAVQDAKGRVKDGIIN
>Mature_478_residues
MNPTLPTLIPYQDHYPYVPVMVKRPLATFDPIAVAKIVHQMGNGFALTIDRHQRYSYFSFKPQRSLTGRQLAKHKRPANE
TLQAILNQYRTPRIQGLPPFTGGLIGYFGYEYIQQFVLKLHLKSPATADLDDLGLFLVTSVLVYDHRHHELGLTQLISTA
DLAATYAVTQTALTQQLAAIIEQLQQPIALPPFDLQQPLHMQADQATYARQVDRIRQHIYAGDIFQMIYANPCLGTMSGS
LLAVYQQLQKTAAPYTCYFKQANFEMTVASPETLVTKDGEQIATYPLAGTRRRGRTPAEDQQLAHELQTSPKEIAEHNML
VDLGRNDLGQVAKFKSVRVTNLRRLIRYSQVMHLGSRVAAEVAPTTTALQVLAATFPAGTLAGAPKIEAMTLINHYEQVP
RGAYGGCFGYLDCNGNLDMAIGIRLAYRMNEQLVIPAGAGIVADSIGAQEFKECQNKQRVIVNAVQDAKGRVKDGIIN

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=409, Percent_Identity=34.718826405868, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1788114, Length=371, Percent_Identity=31.8059299191375, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786809, Length=195, Percent_Identity=29.7435897435897, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320935, Length=422, Percent_Identity=30.3317535545024, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324361, Length=398, Percent_Identity=25.6281407035176, Blast_Score=113, Evalue=8e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53064; Mature: 53064

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPTLPTLIPYQDHYPYVPVMVKRPLATFDPIAVAKIVHQMGNGFALTIDRHQRYSYFSF
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEC
KPQRSLTGRQLAKHKRPANETLQAILNQYRTPRIQGLPPFTGGLIGYFGYEYIQQFVLKL
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HLKSPATADLDDLGLFLVTSVLVYDHRHHELGLTQLISTADLAATYAVTQTALTQQLAAI
HCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEQLQQPIALPPFDLQQPLHMQADQATYARQVDRIRQHIYAGDIFQMIYANPCLGTMSGS
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHH
LLAVYQQLQKTAAPYTCYFKQANFEMTVASPETLVTKDGEQIATYPLAGTRRRGRTPAED
HHHHHHHHHHHCCCEEEEEEECCEEEEECCCCEEEECCCCEEEEECCCCCCCCCCCCCHH
QQLAHELQTSPKEIAEHNMLVDLGRNDLGQVAKFKSVRVTNLRRLIRYSQVMHLGSRVAA
HHHHHHHHCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVAPTTTALQVLAATFPAGTLAGAPKIEAMTLINHYEQVPRGAYGGCFGYLDCNGNLDMA
HHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEE
IGIRLAYRMNEQLVIPAGAGIVADSIGAQEFKECQNKQRVIVNAVQDAKGRVKDGIIN
EEEEEEEECCCEEEEECCCCHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNPTLPTLIPYQDHYPYVPVMVKRPLATFDPIAVAKIVHQMGNGFALTIDRHQRYSYFSF
CCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEEC
KPQRSLTGRQLAKHKRPANETLQAILNQYRTPRIQGLPPFTGGLIGYFGYEYIQQFVLKL
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HLKSPATADLDDLGLFLVTSVLVYDHRHHELGLTQLISTADLAATYAVTQTALTQQLAAI
HCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEQLQQPIALPPFDLQQPLHMQADQATYARQVDRIRQHIYAGDIFQMIYANPCLGTMSGS
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHH
LLAVYQQLQKTAAPYTCYFKQANFEMTVASPETLVTKDGEQIATYPLAGTRRRGRTPAED
HHHHHHHHHHHCCCEEEEEEECCEEEEECCCCEEEECCCCEEEEECCCCCCCCCCCCCHH
QQLAHELQTSPKEIAEHNMLVDLGRNDLGQVAKFKSVRVTNLRRLIRYSQVMHLGSRVAA
HHHHHHHHCCHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVAPTTTALQVLAATFPAGTLAGAPKIEAMTLINHYEQVPRGAYGGCFGYLDCNGNLDMA
HHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEE
IGIRLAYRMNEQLVIPAGAGIVADSIGAQEFKECQNKQRVIVNAVQDAKGRVKDGIIN
EEEEEEEECCCEEEEECCCCHHHHHCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2732211 [H]