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The map label for this gene is gnd2 [H]

Identifier: 28378252

GI number: 28378252

Start: 1407210

End: 1408646

Strand: Direct

Name: gnd2 [H]

Synonym: lp_1541

Alternate gene names: 28378252

Gene position: 1407210-1408646 (Clockwise)

Preceding gene: 28378250

Following gene: 28378253

Centisome position: 42.54

GC content: 45.51

Gene sequence:

>1437_bases
ATGAGTAATGAAAAACCACAAATTGGTGTCATTGGGATGGCCGTCATGGGTAAGAACCTGGCGTTGAACATCGAAAGCCG
CGGCTACAAGGTTGCGATTTTTAATCGGACTGGTGCCAAAACTGAAAAGGTCGTTAAGGACCATGCTGACAAGCAATTAG
TACCAAGTTATAAGATCGAAGACTTCGTGGCTTCACTTGAAACGCCACGACGGATTATCATGATGGTTAAGGCTGGTAAG
CCAACCGATGCCGTTATCGATGAATTATTACCACTATTAGATAAAGGCGACGTCTTGATTGATGGTGGGAACACCAACTT
TAATGACACGATGGCACGTAACGCCCGCTTAGATAAATCCGGAATCAACTTTATTGGTATGGGTGTTTCCGGTGGTGAAT
TAGGTGCCTTACAAGGTCCTTCATTGATGCCTGGTGGTCAAAAGGAAGCTTATGATTTAGTTGCCCCAATCTTGGAAAAG
ATTTCTGCTAAAGCGCCTCAAGACGGTGCACCATGTGTGACTTACATCGGCCCGAACGGTGCTGGTCACTACGTTAAGAT
GGTCCACAACGGGATTGAATACGGTGATGAAGAGTTAATCGATGAATCATACAATATCATGCGCAACGTCGCGGGCTTGT
CCGTTGATGAAATGTCCGATATTTTTACGGACTGGAACAAAGGCGAATTGAGCAGTTACTTGATCGAAATCACCGCTGAC
ATTTTGTCACGTAAGGATGATTTAGGTGCGGATAAGACTAAGCCAATCGTTGACATGATCTTAGACCGTGGGAACAACAA
AGGAACTGGTAAGTGGAGTTCCGAAGATGCCTTGAACGTTCAAGTGCCACAATCCGTTATTACGGAAGCGGTCTATGCGC
GTTACATCTCAATGATGAAGAACGAACGGGTTGCCGCTTCTAAGAAATTAGCTGGCCCAACCGCTGACGTTGACTTGCCA
GCCAAGGAAGAATTGGTTGAGAAGATTCGTCAAGCCCTCTACTTCAGTAAGATTATGAGTTATGCGCAAGGCTTCGAACA
ACTTCGTTTCGCTTCTGAACATTATGGTTGGGACTTGAAGTTCGGTGAACTTGCCCAAATCTGGCGTGCTGGTTGTATCA
TCCGGGCCCAATTCTTACAAAACATCACGGATGCTTTTGATAAGAAGCCTGATTTAAATAACTTATTGATGGACGACTAC
TTTGCCGACATCGCCGCCAAGTATCAACAATCAACACGTGAAGTGCTTAGCTTAGCAATCCAAGCTGGTGTACCGGTACC
ATCATTTAGTGCGGCATTGTCATACTACGACTCATACCGGGCCGAAGTGTTACCTGCTAACTTGTTGCAAGCGCAACGGG
ACTACTTTGGTGCGCATACGTATGAACGGACTGACCGTGAAGGGTTATACCATTACAGTTGGTACGAAGAACAATAA

Upstream 100 bases:

>100_bases
TTATATGAAATTAATTTTAAAATTTGCGGTCATTTACTTTATTAACAGCGTGTTTTTTGGTACGATAGTTGCGTATTAAA
AATTGGGAGGCAATAAACTA

Downstream 100 bases:

>100_bases
AATCATTTTGAATGAACTAAACTGTGGCTAATGACGTTACGCGTGATTAGGCGCAGTTTTTTTGTGCTGTGGGTGGCTGT
GCGGTAATGATCGTTGGTTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSNEKPQIGVIGMAVMGKNLALNIESRGYKVAIFNRTGAKTEKVVKDHADKQLVPSYKIEDFVASLETPRRIIMMVKAGK
PTDAVIDELLPLLDKGDVLIDGGNTNFNDTMARNARLDKSGINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEK
ISAKAPQDGAPCVTYIGPNGAGHYVKMVHNGIEYGDEELIDESYNIMRNVAGLSVDEMSDIFTDWNKGELSSYLIEITAD
ILSRKDDLGADKTKPIVDMILDRGNNKGTGKWSSEDALNVQVPQSVITEAVYARYISMMKNERVAASKKLAGPTADVDLP
AKEELVEKIRQALYFSKIMSYAQGFEQLRFASEHYGWDLKFGELAQIWRAGCIIRAQFLQNITDAFDKKPDLNNLLMDDY
FADIAAKYQQSTREVLSLAIQAGVPVPSFSAALSYYDSYRAEVLPANLLQAQRDYFGAHTYERTDREGLYHYSWYEEQ

Sequences:

>Translated_478_residues
MSNEKPQIGVIGMAVMGKNLALNIESRGYKVAIFNRTGAKTEKVVKDHADKQLVPSYKIEDFVASLETPRRIIMMVKAGK
PTDAVIDELLPLLDKGDVLIDGGNTNFNDTMARNARLDKSGINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEK
ISAKAPQDGAPCVTYIGPNGAGHYVKMVHNGIEYGDEELIDESYNIMRNVAGLSVDEMSDIFTDWNKGELSSYLIEITAD
ILSRKDDLGADKTKPIVDMILDRGNNKGTGKWSSEDALNVQVPQSVITEAVYARYISMMKNERVAASKKLAGPTADVDLP
AKEELVEKIRQALYFSKIMSYAQGFEQLRFASEHYGWDLKFGELAQIWRAGCIIRAQFLQNITDAFDKKPDLNNLLMDDY
FADIAAKYQQSTREVLSLAIQAGVPVPSFSAALSYYDSYRAEVLPANLLQAQRDYFGAHTYERTDREGLYHYSWYEEQ
>Mature_477_residues
SNEKPQIGVIGMAVMGKNLALNIESRGYKVAIFNRTGAKTEKVVKDHADKQLVPSYKIEDFVASLETPRRIIMMVKAGKP
TDAVIDELLPLLDKGDVLIDGGNTNFNDTMARNARLDKSGINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEKI
SAKAPQDGAPCVTYIGPNGAGHYVKMVHNGIEYGDEELIDESYNIMRNVAGLSVDEMSDIFTDWNKGELSSYLIEITADI
LSRKDDLGADKTKPIVDMILDRGNNKGTGKWSSEDALNVQVPQSVITEAVYARYISMMKNERVAASKKLAGPTADVDLPA
KEELVEKIRQALYFSKIMSYAQGFEQLRFASEHYGWDLKFGELAQIWRAGCIIRAQFLQNITDAFDKKPDLNNLLMDDYF
ADIAAKYQQSTREVLSLAIQAGVPVPSFSAALSYYDSYRAEVLPANLLQAQRDYFGAHTYERTDREGLYHYSWYEEQ

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=469, Percent_Identity=50.7462686567164, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1788341, Length=472, Percent_Identity=63.771186440678, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=48.1953290870488, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6321695, Length=464, Percent_Identity=50.4310344827586, Blast_Score=471, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321977, Length=457, Percent_Identity=51.4223194748359, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24639279, Length=467, Percent_Identity=49.678800856531, Blast_Score=452, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52983; Mature: 52852

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEKPQIGVIGMAVMGKNLALNIESRGYKVAIFNRTGAKTEKVVKDHADKQLVPSYKIE
CCCCCCCEEEEEHEEECCCEEEEEECCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHH
DFVASLETPRRIIMMVKAGKPTDAVIDELLPLLDKGDVLIDGGNTNFNDTMARNARLDKS
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCCCCC
GINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEKISAKAPQDGAPCVTYIGPNG
CCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
AGHYVKMVHNGIEYGDEELIDESYNIMRNVAGLSVDEMSDIFTDWNKGELSSYLIEITAD
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
ILSRKDDLGADKTKPIVDMILDRGNNKGTGKWSSEDALNVQVPQSVITEAVYARYISMMK
HHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
NERVAASKKLAGPTADVDLPAKEELVEKIRQALYFSKIMSYAQGFEQLRFASEHYGWDLK
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FGELAQIWRAGCIIRAQFLQNITDAFDKKPDLNNLLMDDYFADIAAKYQQSTREVLSLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAGVPVPSFSAALSYYDSYRAEVLPANLLQAQRDYFGAHTYERTDREGLYHYSWYEEQ
HCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCC
>Mature Secondary Structure 
SNEKPQIGVIGMAVMGKNLALNIESRGYKVAIFNRTGAKTEKVVKDHADKQLVPSYKIE
CCCCCCEEEEEHEEECCCEEEEEECCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCHHH
DFVASLETPRRIIMMVKAGKPTDAVIDELLPLLDKGDVLIDGGNTNFNDTMARNARLDKS
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHCCCCCCC
GINFIGMGVSGGELGALQGPSLMPGGQKEAYDLVAPILEKISAKAPQDGAPCVTYIGPNG
CCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
AGHYVKMVHNGIEYGDEELIDESYNIMRNVAGLSVDEMSDIFTDWNKGELSSYLIEITAD
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHH
ILSRKDDLGADKTKPIVDMILDRGNNKGTGKWSSEDALNVQVPQSVITEAVYARYISMMK
HHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHH
NERVAASKKLAGPTADVDLPAKEELVEKIRQALYFSKIMSYAQGFEQLRFASEHYGWDLK
CCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FGELAQIWRAGCIIRAQFLQNITDAFDKKPDLNNLLMDDYFADIAAKYQQSTREVLSLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAGVPVPSFSAALSYYDSYRAEVLPANLLQAQRDYFGAHTYERTDREGLYHYSWYEEQ
HCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]