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The map label for this gene is argD [H]

Identifier: 28377417

GI number: 28377417

Start: 479989

End: 481158

Strand: Direct

Name: argD [H]

Synonym: lp_0531

Alternate gene names: 28377417

Gene position: 479989-481158 (Clockwise)

Preceding gene: 28377416

Following gene: 28377418

Centisome position: 14.51

GC content: 49.57

Gene sequence:

>1170_bases
ATGACCATGCAACACGTGTTTCCAACCTATCAACGTTTTCCATTTGCCATTACGGATGGTCAGGGCGTTCATCTGACTGA
TAATCATGGCAAGACGTATTTAGATTTTACGGCGGGAATCGGGGTCTGCAACTTTGGGTATCACCAACCACAAATTCAGG
CGGCCGTCACCCAGCAGTTGACGCATATCTGGCATACGTCGAATTTATACGAAAATGAATTACAAGATGCCGTTGCCGGC
CTGTTAGCGAATGGTGAAGAGCGACTCGTATACTTTGCAAATTCCGGAACCGAAGCTAATGAAGCTGCATTAAAACTCGC
ACGGAAGTACACGGGTAAAACCGGCATCTTAGCTTTTCAGCATTCATTTCACGGTCGAACCTATGGCGCTATGTCGATGA
CGGGCAATCCTCATATTCAGGCTGGCTATGCGCCATTAGTGCCTGGCATCACGTTTGCAACCTATAATGACGACGCGGCT
TTGGACAAAATCACACCAGAGTTGGCGGCCGTTATTTTAGAAGTCGTTCAAGGTGAAGGCGGCGTCTTTGCGGGACAAAC
AGCTTGGTTACAAGCGGTTAATGCGAAATGCCAAGCAACGGGTGTTTTGTTGATTATTGATGAGGTGCAGACGGGAATCG
GTCGGACTGGTTACCGGATGGCCTATGAAGGTTACGGCCTGGATCCTGATATCTACACGGTCGCCAAGGGCTTAGCGAAT
GGCTTGCCAGTGGGGGCAATGGTTGGTCGGCGGCAATTAGCCACTGCCTTTGGTCCGGGCAGCCATGGCTCGACGTTCGC
CGGTAATGCTGTTGCTATGGCGGCGGCAAAATGTGTCTTGCCCCAATTAACACCGGCGCTGTTAACGACGGTTCGAGCCC
ATGCCAAACTTGTCTGGCAATCCCTAGCGACTCAAGTCGAACCGATACCGGTAGTGAAACAAATCACGGGGAAGGGCCTA
ATGATTGGAATCCACTTAGATGAACAAATCCCGGTTAATCAAGTCATCACCCGGCTACAAGTAGAAGGCTTATTGACGTT
ATCAGCTGGCGATAATACGTTACGTTTGTTACCCCCAATTGTGATGCAACCGGCCGATTTATTAGCTGGGATTGCCTTGA
TTGCAAAGGTACTGACAACTTTGACAACGGAGGTCACGACGAATGAATAA

Upstream 100 bases:

>100_bases
TTCAAGCTGCAATTGCCGCGATTCAGACGGGAGTCAAGCAGGCTATTATTACGAATGCAATCGATCAACCAGGAACCGCA
ATTATTCAGGAGGTGGCCGT

Downstream 100 bases:

>100_bases
TCAATTTGAAGGTCGGTCATTCTTGAAGGAAATCGACTATACACCAACAGAATTAGCTTACTTAATTGACTTTGCTAGTC
ACTTGAAGACCCTTAAAGCA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNFGYHQPQIQAAVTQQLTHIWHTSNLYENELQDAVAG
LLANGEERLVYFANSGTEANEAALKLARKYTGKTGILAFQHSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAA
LDKITPELAAVILEVVQGEGGVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAYEGYGLDPDIYTVAKGLAN
GLPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKCVLPQLTPALLTTVRAHAKLVWQSLATQVEPIPVVKQITGKGL
MIGIHLDEQIPVNQVITRLQVEGLLTLSAGDNTLRLLPPIVMQPADLLAGIALIAKVLTTLTTEVTTNE

Sequences:

>Translated_389_residues
MTMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNFGYHQPQIQAAVTQQLTHIWHTSNLYENELQDAVAG
LLANGEERLVYFANSGTEANEAALKLARKYTGKTGILAFQHSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAA
LDKITPELAAVILEVVQGEGGVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAYEGYGLDPDIYTVAKGLAN
GLPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKCVLPQLTPALLTTVRAHAKLVWQSLATQVEPIPVVKQITGKGL
MIGIHLDEQIPVNQVITRLQVEGLLTLSAGDNTLRLLPPIVMQPADLLAGIALIAKVLTTLTTEVTTNE
>Mature_388_residues
TMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNFGYHQPQIQAAVTQQLTHIWHTSNLYENELQDAVAGL
LANGEERLVYFANSGTEANEAALKLARKYTGKTGILAFQHSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAAL
DKITPELAAVILEVVQGEGGVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAYEGYGLDPDIYTVAKGLANG
LPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKCVLPQLTPALLTTVRAHAKLVWQSLATQVEPIPVVKQITGKGLM
IGIHLDEQIPVNQVITRLQVEGLLTLSAGDNTLRLLPPIVMQPADLLAGIALIAKVLTTLTTEVTTNE

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=390, Percent_Identity=31.025641025641, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=32.5581395348837, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI13994255, Length=440, Percent_Identity=26.8181818181818, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI37574042, Length=443, Percent_Identity=26.410835214447, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI226442705, Length=445, Percent_Identity=26.2921348314607, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI24119277, Length=424, Percent_Identity=26.8867924528302, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI226442709, Length=395, Percent_Identity=26.5822784810127, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1788044, Length=384, Percent_Identity=38.28125, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789759, Length=388, Percent_Identity=36.5979381443299, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789016, Length=402, Percent_Identity=33.0845771144279, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1787560, Length=399, Percent_Identity=32.3308270676692, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI145693181, Length=368, Percent_Identity=33.1521739130435, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=30.6590257879656, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786991, Length=288, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=411, Percent_Identity=29.683698296837, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=30.6791569086651, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=399, Percent_Identity=27.0676691729323, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=25.9345794392523, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71981843, Length=177, Percent_Identity=28.8135593220339, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=35.0253807106599, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6323470, Length=404, Percent_Identity=31.6831683168317, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=294, Percent_Identity=27.891156462585, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357415, Length=389, Percent_Identity=31.1053984575836, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI28574759, Length=427, Percent_Identity=28.1030444964871, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI161085790, Length=410, Percent_Identity=28.0487804878049, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21356575, Length=419, Percent_Identity=26.9689737470167, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI281366494, Length=279, Percent_Identity=25.4480286738351, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=279, Percent_Identity=25.4480286738351, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=279, Percent_Identity=25.4480286738351, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41459; Mature: 41328

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNFGYHQPQIQAAVTQQL
CCCCHHCCHHHHCCEEEECCCEEEEECCCCCEEEEEECCCCEECCCCCCCHHHHHHHHHH
THIWHTSNLYENELQDAVAGLLANGEERLVYFANSGTEANEAALKLARKYTGKTGILAFQ
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
HSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAALDKITPELAAVILEVVQGEG
ECCCCCEEEEEEECCCCCEECCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHHHCCCC
GVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAYEGYGLDPDIYTVAKGLAN
CEEECHHHHHHHHCCCHHHCEEEEEEECHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHC
GLPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKCVLPQLTPALLTTVRAHAKLVWQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLATQVEPIPVVKQITGKGLMIGIHLDEQIPVNQVITRLQVEGLLTLSAGDNTLRLLPPI
HHHHCCCCCCHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCEEEECCHH
VMQPADLLAGIALIAKVLTTLTTEVTTNE
HCCHHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
TMQHVFPTYQRFPFAITDGQGVHLTDNHGKTYLDFTAGIGVCNFGYHQPQIQAAVTQQL
CCCHHCCHHHHCCEEEECCCEEEEECCCCCEEEEEECCCCEECCCCCCCHHHHHHHHHH
THIWHTSNLYENELQDAVAGLLANGEERLVYFANSGTEANEAALKLARKYTGKTGILAFQ
HHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
HSFHGRTYGAMSMTGNPHIQAGYAPLVPGITFATYNDDAALDKITPELAAVILEVVQGEG
ECCCCCEEEEEEECCCCCEECCCCCCCCCEEEEEECCCCHHHHCCHHHHHHHHHHHCCCC
GVFAGQTAWLQAVNAKCQATGVLLIIDEVQTGIGRTGYRMAYEGYGLDPDIYTVAKGLAN
CEEECHHHHHHHHCCCHHHCEEEEEEECHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHC
GLPVGAMVGRRQLATAFGPGSHGSTFAGNAVAMAAAKCVLPQLTPALLTTVRAHAKLVWQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SLATQVEPIPVVKQITGKGLMIGIHLDEQIPVNQVITRLQVEGLLTLSAGDNTLRLLPPI
HHHHCCCCCCHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCEEEECCHH
VMQPADLLAGIALIAKVLTTLTTEVTTNE
HCCHHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9098069; 12566566 [H]