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The map label for this gene is serS1

Identifier: 28377392

GI number: 28377392

Start: 448814

End: 450085

Strand: Direct

Name: serS1

Synonym: lp_0501

Alternate gene names: 28377392

Gene position: 448814-450085 (Clockwise)

Preceding gene: 28377391

Following gene: 28377393

Centisome position: 13.57

GC content: 46.31

Gene sequence:

>1272_bases
ATGTTAAATCCAAAGTTTGTTCGTAATAACCCAGAACTTGTTAAGACTAAGCTCCAGACTCGGAAGGTTGATCCGGCTGA
GGTTGATGAATACTTACAGTTAGACCAACAAAACCGGGATGCAATTACCAAGGTTGAAGGATTGAAGAAACAGAAAAACC
AGTTGACGGAACAAATTGGGCAAAGTGATCCGCAATCGGAAGCGGGCCAAGCCCTCATTCAACAAGTCAAACAGCTGAAT
GGTGATATTAAGAGTACGGAAGCGGCCCAAACGGAAGTAAACGATCGGCTTCATTACTTAGCGATTCGCTTCCCGAATTT
ACCTGCCGATGATGTACCAGTCGGTCCTGACGAAGATAGCAATGTTGAGATGCGTAAGCACGGCGATATTCCAACGTTTG
ATTTTAAACCTAAGGCGCACTGGGAATTGGGCGAAAGCTTAGGAATCTTGGATTTTGACCGGGCAGCAAAAGTCGCGGGC
GCGCGCTTTGTTTATTATAAGGATGCGGGTGCACTCTTAGAACGGGCGGTTTACAGCTTTATGCTAGATCTGCACACACA
AAAGCAAGGGTACCATGAAATTATTCCGCCATACTTGGTGAACGCTCAGACAATGTATGGAACTGGGCAATTTCCGAAGT
TCAAAGAAGACGTCTACACGGTTGAATCTTCAGGAATGACGTTGATCCCGACGGCTGAAGTACCGCTGACCAATTACTAT
GCGAATGAAATCTTATCTGAAGATCAATTGCCAACGTACTTCACGGCGATGACGCCTTGTTATCGCTCCGAAGCTGGGAG
TGCGGGGCGTGATACCCGGGGCTTGATTCGTATGCACCAATTTCACAAAGTCGAGATGGTCAAGTACTGTAAACCTGAGA
ATTCATACGATGAGCTCGAAAAATTAACGGATAATGCCGAAGAAGTGTTGCGCGAATTAGGGCTTGCATACCATGTTATT
AAGCTTTCAACGGGGGATACTGGTTTCTCATCAGCCAAGACCTATGATGTGGAAGTATGGATGCCAGAACAAGGCGTTTA
TCGGGAAATCAGTTCATGCTCTAACTGCTTGGACTTCCAAGCACGGCGGGCGATGATTCGTTACCGGAAAGCTGATGGGA
CGGTCGATTACGTCCATACGTTGAATGGTTCTGGACTTGCTGTTGGCCGGACGGTAGCTGCGATTTTGGAAAATTATCAA
CAAGCCGATGGCACGGTTAAGATTCCTAAGGTGCTCCAACCTTACATGCATGGTATGACAGAGATAAAATAA

Upstream 100 bases:

>100_bases
CGTAGAGCAGTAAATTGGGTGGTACCACGTTGATAAAAAACGTCCCATAGTCTTTTAGGTGAAGACTATGGGACGTTTTA
ATTTTAAGGAGGCTTTTCGT

Downstream 100 bases:

>100_bases
AATTATTATGAGAATAAATTATTATTCAAATAATTCATTTGAATGTTAAACTTAATATCACTAGGATTGAGATGGATACA
GGCTAGGACTGTTATGGTAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase 1; SerRS 1; Seryl-tRNA(Ser/Sec) synthetase 1

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLNPKFVRNNPELVKTKLQTRKVDPAEVDEYLQLDQQNRDAITKVEGLKKQKNQLTEQIGQSDPQSEAGQALIQQVKQLN
GDIKSTEAAQTEVNDRLHYLAIRFPNLPADDVPVGPDEDSNVEMRKHGDIPTFDFKPKAHWELGESLGILDFDRAAKVAG
ARFVYYKDAGALLERAVYSFMLDLHTQKQGYHEIIPPYLVNAQTMYGTGQFPKFKEDVYTVESSGMTLIPTAEVPLTNYY
ANEILSEDQLPTYFTAMTPCYRSEAGSAGRDTRGLIRMHQFHKVEMVKYCKPENSYDELEKLTDNAEEVLRELGLAYHVI
KLSTGDTGFSSAKTYDVEVWMPEQGVYREISSCSNCLDFQARRAMIRYRKADGTVDYVHTLNGSGLAVGRTVAAILENYQ
QADGTVKIPKVLQPYMHGMTEIK

Sequences:

>Translated_423_residues
MLNPKFVRNNPELVKTKLQTRKVDPAEVDEYLQLDQQNRDAITKVEGLKKQKNQLTEQIGQSDPQSEAGQALIQQVKQLN
GDIKSTEAAQTEVNDRLHYLAIRFPNLPADDVPVGPDEDSNVEMRKHGDIPTFDFKPKAHWELGESLGILDFDRAAKVAG
ARFVYYKDAGALLERAVYSFMLDLHTQKQGYHEIIPPYLVNAQTMYGTGQFPKFKEDVYTVESSGMTLIPTAEVPLTNYY
ANEILSEDQLPTYFTAMTPCYRSEAGSAGRDTRGLIRMHQFHKVEMVKYCKPENSYDELEKLTDNAEEVLRELGLAYHVI
KLSTGDTGFSSAKTYDVEVWMPEQGVYREISSCSNCLDFQARRAMIRYRKADGTVDYVHTLNGSGLAVGRTVAAILENYQ
QADGTVKIPKVLQPYMHGMTEIK
>Mature_423_residues
MLNPKFVRNNPELVKTKLQTRKVDPAEVDEYLQLDQQNRDAITKVEGLKKQKNQLTEQIGQSDPQSEAGQALIQQVKQLN
GDIKSTEAAQTEVNDRLHYLAIRFPNLPADDVPVGPDEDSNVEMRKHGDIPTFDFKPKAHWELGESLGILDFDRAAKVAG
ARFVYYKDAGALLERAVYSFMLDLHTQKQGYHEIIPPYLVNAQTMYGTGQFPKFKEDVYTVESSGMTLIPTAEVPLTNYY
ANEILSEDQLPTYFTAMTPCYRSEAGSAGRDTRGLIRMHQFHKVEMVKYCKPENSYDELEKLTDNAEEVLRELGLAYHVI
KLSTGDTGFSSAKTYDVEVWMPEQGVYREISSCSNCLDFQARRAMIRYRKADGTVDYVHTLNGSGLAVGRTVAAILENYQ
QADGTVKIPKVLQPYMHGMTEIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI8923421, Length=425, Percent_Identity=30.8235294117647, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI225579074, Length=428, Percent_Identity=31.3084112149533, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI16306548, Length=452, Percent_Identity=31.1946902654867, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=50, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539260, Length=451, Percent_Identity=33.2594235033259, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17542084, Length=398, Percent_Identity=28.894472361809, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=431, Percent_Identity=32.2505800464037, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=34.7222222222222, Blast_Score=200, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24581334, Length=455, Percent_Identity=30.989010989011, Blast_Score=214, Evalue=8e-56,
Organism=Drosophila melanogaster, GI17737985, Length=281, Percent_Identity=37.3665480427046, Blast_Score=181, Evalue=9e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS1_LACPL (Q88Z60)

Other databases:

- EMBL:   AL935253
- RefSeq:   NP_784284.1
- ProteinModelPortal:   Q88Z60
- SMR:   Q88Z60
- GeneID:   1061485
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0501
- NMPDR:   fig|220668.1.peg.418
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- ProtClustDB:   PRK05431
- BioCyc:   LPLA220668:LP_0501-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47786; Mature: 47786

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNPKFVRNNPELVKTKLQTRKVDPAEVDEYLQLDQQNRDAITKVEGLKKQKNQLTEQIG
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
QSDPQSEAGQALIQQVKQLNGDIKSTEAAQTEVNDRLHYLAIRFPNLPADDVPVGPDEDS
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCC
NVEMRKHGDIPTFDFKPKAHWELGESLGILDFDRAAKVAGARFVYYKDAGALLERAVYSF
CCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHH
MLDLHTQKQGYHEIIPPYLVNAQTMYGTGQFPKFKEDVYTVESSGMTLIPTAEVPLTNYY
HHHHHHHCCCCHHCCCCHHCCCEEEECCCCCCCHHHHHEEEECCCEEEEECCCCCCHHHH
ANEILSEDQLPTYFTAMTPCYRSEAGSAGRDTRGLIRMHQFHKVEMVKYCKPENSYDELE
HHHHHCCCCCCHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLTDNAEEVLRELGLAYHVIKLSTGDTGFSSAKTYDVEVWMPEQGVYREISSCSNCLDFQ
HHHCCHHHHHHHHCHHEEEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHH
ARRAMIRYRKADGTVDYVHTLNGSGLAVGRTVAAILENYQQADGTVKIPKVLQPYMHGMT
HHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHH
EIK
CCC
>Mature Secondary Structure
MLNPKFVRNNPELVKTKLQTRKVDPAEVDEYLQLDQQNRDAITKVEGLKKQKNQLTEQIG
CCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
QSDPQSEAGQALIQQVKQLNGDIKSTEAAQTEVNDRLHYLAIRFPNLPADDVPVGPDEDS
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCC
NVEMRKHGDIPTFDFKPKAHWELGESLGILDFDRAAKVAGARFVYYKDAGALLERAVYSF
CCCHHHCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHCCEEEEECCHHHHHHHHHHHH
MLDLHTQKQGYHEIIPPYLVNAQTMYGTGQFPKFKEDVYTVESSGMTLIPTAEVPLTNYY
HHHHHHHCCCCHHCCCCHHCCCEEEECCCCCCCHHHHHEEEECCCEEEEECCCCCCHHHH
ANEILSEDQLPTYFTAMTPCYRSEAGSAGRDTRGLIRMHQFHKVEMVKYCKPENSYDELE
HHHHHCCCCCCHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KLTDNAEEVLRELGLAYHVIKLSTGDTGFSSAKTYDVEVWMPEQGVYREISSCSNCLDFQ
HHHCCHHHHHHHHCHHEEEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHH
ARRAMIRYRKADGTVDYVHTLNGSGLAVGRTVAAILENYQQADGTVKIPKVLQPYMHGMT
HHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHH
EIK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566