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The map label for this gene is sdaC [H]

Identifier: 28377393

GI number: 28377393

Start: 450437

End: 451717

Strand: Direct

Name: sdaC [H]

Synonym: lp_0502

Alternate gene names: 28377393

Gene position: 450437-451717 (Clockwise)

Preceding gene: 28377392

Following gene: 28377394

Centisome position: 13.62

GC content: 38.41

Gene sequence:

>1281_bases
ATGACAAATATATTTAAGGGTTGGAGAAAAAATGATACTTTTTGGATGCTGAGTTTGTTCGGAACGGCGATTGGGGCCGG
CGTGCTATTCTTACCGATTGGAGTTGGCACGGCAGGTATTCTTGGTATCATCATGATACTTATTTTGGCTTTGCCAACCA
CATTTTTTGCTCACAGGGGCCTGAGTAGGTTTGTCTTGTCGGCTAAAAATGATGGTGATGACATTACTGATGTTGTTGAA
CAACATTTTGGCTTTAAGATTGGATTGCTTTTTACCATTATTTATTTCTTCTCCATTTATCCAATCTTATTAGTTTATTC
TGTTTCTATTACGAATACTGTATCGAAATTTATTACCGACCAAATGCACATGCAAACACCACCTCGTTGGCTGTTGTCGC
TAGTACTTGTTGGGATTCTCATTGGAATTGCTCGCTTTGGTACCTCTTTGATTACCAAAGTTATGAGTGGCCTGGCCTTT
CCATTTATTATTGTAATCGTTCTGTTTTCCTTTTATCTTATTCCGCATTGGAACGGCGCAATCCTCTCAACATTTTCCAG
TTCTGTATCTGGGGGACATTTGGTTGGCACTTTAGGAAACTTGTGGTTACTTATTCCTGTTATGATCTTTTCGTTTAACC
ATTCTCCGATCATCTCTTCATTTTCCGTTGCCGAACGTAAAGAATATAGTGGGGAAGGTAAGGACAAAGTCGATAAAAAG
ATTTCGACAATTCTATTGTCGGCCGAAACGTTGATGGTCATTGTCGCAATGTTCTTTGTTATTAGTTGTACATTGGCGTT
GACTCCAGACCAAATCCTTGAAGCTAAAAATGAAAATGTTTCAATCCTTGATTACGTTGCGACTGCTTTCAATAATCCAA
TTATTAAATATGTTTCTCCCGTAATTGCTTTTATTGCAATCGCCAAGTCCTTTTTAGGACATTATCTAGGAACGAGTGAA
GGCTTACGTGGGATTATTCGTAAGATGGAAGAAAAATCTAACAAGACGCTTTCAAGTCGAACTGTTTCGACAATTGTTGA
TCTTGTTCTGCTACTAAGTGCCTGGATAGTTGCCTGGGTCAATCCTTCCATTATGGGAATGATTGAAACCATCATTGGAC
CAATCATTGCGTTTATCTTGTTCTTGATGCCAATGTATGCCATTCATAAAAGTCCTAAGTTACAGCAATATGCCGGCAAA
CACAGCAATGTCTTTGTTGTGGTAATTGGATTAATCGCAGTTAGTGGTATCCTGTTCAATATCATCAAATTGTTTATTTA
G

Upstream 100 bases:

>100_bases
GAGTCGAGACGTTAAATCTAATGGGAGGGTTATTCATGCAGGTTATGTTAGCACATTCTCTGGTGTGACCAGAACAACGT
TATAAAAAGGAGATTTAAAA

Downstream 100 bases:

>100_bases
TAATCTGACTAAAATACGAGATGAATTCACATTGGTTAATATTATTGAAGCCAATTTTTGTCATAAATCTCGTTGCTAGT
GTTATTGACGAGATTCGCAT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTNIFKGWRKNDTFWMLSLFGTAIGAGVLFLPIGVGTAGILGIIMILILALPTTFFAHRGLSRFVLSAKNDGDDITDVVE
QHFGFKIGLLFTIIYFFSIYPILLVYSVSITNTVSKFITDQMHMQTPPRWLLSLVLVGILIGIARFGTSLITKVMSGLAF
PFIIVIVLFSFYLIPHWNGAILSTFSSSVSGGHLVGTLGNLWLLIPVMIFSFNHSPIISSFSVAERKEYSGEGKDKVDKK
ISTILLSAETLMVIVAMFFVISCTLALTPDQILEAKNENVSILDYVATAFNNPIIKYVSPVIAFIAIAKSFLGHYLGTSE
GLRGIIRKMEEKSNKTLSSRTVSTIVDLVLLLSAWIVAWVNPSIMGMIETIIGPIIAFILFLMPMYAIHKSPKLQQYAGK
HSNVFVVVIGLIAVSGILFNIIKLFI

Sequences:

>Translated_426_residues
MTNIFKGWRKNDTFWMLSLFGTAIGAGVLFLPIGVGTAGILGIIMILILALPTTFFAHRGLSRFVLSAKNDGDDITDVVE
QHFGFKIGLLFTIIYFFSIYPILLVYSVSITNTVSKFITDQMHMQTPPRWLLSLVLVGILIGIARFGTSLITKVMSGLAF
PFIIVIVLFSFYLIPHWNGAILSTFSSSVSGGHLVGTLGNLWLLIPVMIFSFNHSPIISSFSVAERKEYSGEGKDKVDKK
ISTILLSAETLMVIVAMFFVISCTLALTPDQILEAKNENVSILDYVATAFNNPIIKYVSPVIAFIAIAKSFLGHYLGTSE
GLRGIIRKMEEKSNKTLSSRTVSTIVDLVLLLSAWIVAWVNPSIMGMIETIIGPIIAFILFLMPMYAIHKSPKLQQYAGK
HSNVFVVVIGLIAVSGILFNIIKLFI
>Mature_425_residues
TNIFKGWRKNDTFWMLSLFGTAIGAGVLFLPIGVGTAGILGIIMILILALPTTFFAHRGLSRFVLSAKNDGDDITDVVEQ
HFGFKIGLLFTIIYFFSIYPILLVYSVSITNTVSKFITDQMHMQTPPRWLLSLVLVGILIGIARFGTSLITKVMSGLAFP
FIIVIVLFSFYLIPHWNGAILSTFSSSVSGGHLVGTLGNLWLLIPVMIFSFNHSPIISSFSVAERKEYSGEGKDKVDKKI
STILLSAETLMVIVAMFFVISCTLALTPDQILEAKNENVSILDYVATAFNNPIIKYVSPVIAFIAIAKSFLGHYLGTSEG
LRGIIRKMEEKSNKTLSSRTVSTIVDLVLLLSAWIVAWVNPSIMGMIETIIGPIIAFILFLMPMYAIHKSPKLQQYAGKH
SNVFVVVIGLIAVSGILFNIIKLFI

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=416, Percent_Identity=56.0096153846154, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1789504, Length=428, Percent_Identity=44.1588785046729, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1789211, Length=423, Percent_Identity=35.6973995271868, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1789961, Length=405, Percent_Identity=26.1728395061728, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI145693183, Length=438, Percent_Identity=25.7990867579909, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46887; Mature: 46756

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIFKGWRKNDTFWMLSLFGTAIGAGVLFLPIGVGTAGILGIIMILILALPTTFFAHRG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
LSRFVLSAKNDGDDITDVVEQHFGFKIGLLFTIIYFFSIYPILLVYSVSITNTVSKFITD
HHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMHMQTPPRWLLSLVLVGILIGIARFGTSLITKVMSGLAFPFIIVIVLFSFYLIPHWNGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ILSTFSSSVSGGHLVGTLGNLWLLIPVMIFSFNHSPIISSFSVAERKEYSGEGKDKVDKK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
ISTILLSAETLMVIVAMFFVISCTLALTPDQILEAKNENVSILDYVATAFNNPIIKYVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH
VIAFIAIAKSFLGHYLGTSEGLRGIIRKMEEKSNKTLSSRTVSTIVDLVLLLSAWIVAWV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
NPSIMGMIETIIGPIIAFILFLMPMYAIHKSPKLQQYAGKHSNVFVVVIGLIAVSGILFN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
IIKLFI
HHHHHC
>Mature Secondary Structure 
TNIFKGWRKNDTFWMLSLFGTAIGAGVLFLPIGVGTAGILGIIMILILALPTTFFAHRG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
LSRFVLSAKNDGDDITDVVEQHFGFKIGLLFTIIYFFSIYPILLVYSVSITNTVSKFITD
HHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMHMQTPPRWLLSLVLVGILIGIARFGTSLITKVMSGLAFPFIIVIVLFSFYLIPHWNGA
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ILSTFSSSVSGGHLVGTLGNLWLLIPVMIFSFNHSPIISSFSVAERKEYSGEGKDKVDKK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
ISTILLSAETLMVIVAMFFVISCTLALTPDQILEAKNENVSILDYVATAFNNPIIKYVSP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHH
VIAFIAIAKSFLGHYLGTSEGLRGIIRKMEEKSNKTLSSRTVSTIVDLVLLLSAWIVAWV
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
NPSIMGMIETIIGPIIAFILFLMPMYAIHKSPKLQQYAGKHSNVFVVVIGLIAVSGILFN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHH
IIKLFI
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]