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The map label for this gene is argC1

Identifier: 28377381

GI number: 28377381

Start: 434924

End: 435955

Strand: Direct

Name: argC1

Synonym: lp_0487

Alternate gene names: 28377381

Gene position: 434924-435955 (Clockwise)

Preceding gene: 28377380

Following gene: 28377382

Centisome position: 13.15

GC content: 35.95

Gene sequence:

>1032_bases
TTGAAAAATAATATGAAAGTTGGAATCTTAGGTGGCTCTGGCTATGCTGGTGCAGAGCTGTACCGCTTGTTACTAAATCA
TCCGAATTTTAACGTTACTTTTATATCATCTGAAAAGTATGCTGGTAAACCTGTTGAGAAAATGTTGAAAGGTTTTGCAC
ATAACGGTCATTCGCATAATTTACGGTTCAATCATCTAGATGATTTACCATTTGATTTAGACTTCGTTTTTTCAGCGCTG
CCTACTGGTGTATTGCCAAAGTATGTTGAAAAGATTCTCGAAAAAACTAGTTTAATTTTTAATGTTAGTGGTGATTTCCG
TTTTAAAGATGCCACAACACTTCAGCAATACTATCCGGAAACATTAGCAATTGAAAGTGACCAGATCTTATCGTCATATT
ATATTCCTGAATTTAGTGATTTCGACAAAAACGCCAATATCATTAACTTACCAGGGTGTATGGCACTAGCTTCTATTTAT
GCTGCATATCCTTTAGTGAAAAATAAACTAATTAATCCGAATATTTTTGTTGATGTAAAAACTGGTTCAAGTGGCGCAGG
AAAATCAACAAAAGAAACTGCAGCTGATAGATTTGGCAATTTCCGATTGTATAGAGCGTTCAATCATCGGCATCTACCTG
AAATTGCGATGGCTTTAGGATCCTCTGTGGGTAAAGTGGGCTTTGCTGCATACTCACTAGATATTTCACGTGGAATTTAC
GCCAGCGTTTATTCTCAAATTAAAAAGGGTGTGACAGAAGTTGATGTAAAAAAAGCTTATTTTAAAACTTATAAATCTTG
CAAATTTGTAGCTAATTTAACTGGTAAGCAAAGTGTTCCAATGTTGAAGTCGACTAATGGTACTAATTTTGCTGAAGTAA
AGGCAACTGTTCACGAAGGACAATGCATTGCCGTAGTTTCTTTAGACAATTTATTAAAAGGTGCGGCCGGTCAGGCGGTT
CAAGCTGCTAATAAATACTATCAGTTAGTTGAAGATACAGGATTAGATACTTTAGCAGGGATGTGGCCATAA

Upstream 100 bases:

>100_bases
AAGTCGCATTCAAAAAACTGGATAATCATATTGGGGAAATTGCTGAGATGGCTAAAGCTTTGAATGTTAAAAAACCATAC
GAAAGGGATGCTAGATTAGG

Downstream 100 bases:

>100_bases
TGCAGAACATATTCGTTCTTAAGCTCGGTAGTAGTACTGTTTTACATGGAGCACAAATTTACAATCAAATTTCAGCACTT
GTAGAACAAGGTTCTAAAGT

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR 1; N-acetyl-glutamate semialdehyde dehydrogenase 1; NAGSA dehydrogenase 1

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKNNMKVGILGGSGYAGAELYRLLLNHPNFNVTFISSEKYAGKPVEKMLKGFAHNGHSHNLRFNHLDDLPFDLDFVFSAL
PTGVLPKYVEKILEKTSLIFNVSGDFRFKDATTLQQYYPETLAIESDQILSSYYIPEFSDFDKNANIINLPGCMALASIY
AAYPLVKNKLINPNIFVDVKTGSSGAGKSTKETAADRFGNFRLYRAFNHRHLPEIAMALGSSVGKVGFAAYSLDISRGIY
ASVYSQIKKGVTEVDVKKAYFKTYKSCKFVANLTGKQSVPMLKSTNGTNFAEVKATVHEGQCIAVVSLDNLLKGAAGQAV
QAANKYYQLVEDTGLDTLAGMWP

Sequences:

>Translated_343_residues
MKNNMKVGILGGSGYAGAELYRLLLNHPNFNVTFISSEKYAGKPVEKMLKGFAHNGHSHNLRFNHLDDLPFDLDFVFSAL
PTGVLPKYVEKILEKTSLIFNVSGDFRFKDATTLQQYYPETLAIESDQILSSYYIPEFSDFDKNANIINLPGCMALASIY
AAYPLVKNKLINPNIFVDVKTGSSGAGKSTKETAADRFGNFRLYRAFNHRHLPEIAMALGSSVGKVGFAAYSLDISRGIY
ASVYSQIKKGVTEVDVKKAYFKTYKSCKFVANLTGKQSVPMLKSTNGTNFAEVKATVHEGQCIAVVSLDNLLKGAAGQAV
QAANKYYQLVEDTGLDTLAGMWP
>Mature_343_residues
MKNNMKVGILGGSGYAGAELYRLLLNHPNFNVTFISSEKYAGKPVEKMLKGFAHNGHSHNLRFNHLDDLPFDLDFVFSAL
PTGVLPKYVEKILEKTSLIFNVSGDFRFKDATTLQQYYPETLAIESDQILSSYYIPEFSDFDKNANIINLPGCMALASIY
AAYPLVKNKLINPNIFVDVKTGSSGAGKSTKETAADRFGNFRLYRAFNHRHLPEIAMALGSSVGKVGFAAYSLDISRGIY
ASVYSQIKKGVTEVDVKKAYFKTYKSCKFVANLTGKQSVPMLKSTNGTNFAEVKATVHEGQCIAVVSLDNLLKGAAGQAV
QAANKYYQLVEDTGLDTLAGMWP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=341, Percent_Identity=33.1378299120235, Blast_Score=133, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320913, Length=336, Percent_Identity=29.7619047619048, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC1_LACPL (P59391)

Other databases:

- EMBL:   AL935253
- RefSeq:   NP_784273.1
- ProteinModelPortal:   P59391
- SMR:   P59391
- GeneID:   1061450
- GenomeReviews:   AL935263_GR
- KEGG:   lpl:lp_0487
- NMPDR:   fig|220668.1.peg.407
- HOGENOM:   HBG294213
- OMA:   GSSHIGR
- BioCyc:   LPLA220668:LP_0487-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh

EC number: =1.2.1.38

Molecular weight: Translated: 37700; Mature: 37700

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 153-153

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNMKVGILGGSGYAGAELYRLLLNHPNFNVTFISSEKYAGKPVEKMLKGFAHNGHSHN
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCC
LRFNHLDDLPFDLDFVFSALPTGVLPKYVEKILEKTSLIFNVSGDFRFKDATTLQQYYPE
EEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCEEECCHHHHHHHCCH
TLAIESDQILSSYYIPEFSDFDKNANIINLPGCMALASIYAAYPLVKNKLINPNIFVDVK
HEEECHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
TGSSGAGKSTKETAADRFGNFRLYRAFNHRHLPEIAMALGSSVGKVGFAAYSLDISRGIY
CCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEHHCCHH
ASVYSQIKKGVTEVDVKKAYFKTYKSCKFVANLTGKQSVPMLKSTNGTNFAEVKATVHEG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEECCCCCCEEEEEEEEECC
QCIAVVSLDNLLKGAAGQAVQAANKYYQLVEDTGLDTLAGMWP
CEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MKNNMKVGILGGSGYAGAELYRLLLNHPNFNVTFISSEKYAGKPVEKMLKGFAHNGHSHN
CCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCC
LRFNHLDDLPFDLDFVFSALPTGVLPKYVEKILEKTSLIFNVSGDFRFKDATTLQQYYPE
EEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCEEECCHHHHHHHCCH
TLAIESDQILSSYYIPEFSDFDKNANIINLPGCMALASIYAAYPLVKNKLINPNIFVDVK
HEEECHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
TGSSGAGKSTKETAADRFGNFRLYRAFNHRHLPEIAMALGSSVGKVGFAAYSLDISRGIY
CCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEHHCCHH
ASVYSQIKKGVTEVDVKKAYFKTYKSCKFVANLTGKQSVPMLKSTNGTNFAEVKATVHEG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEECCCCCCEEEEEEEEECC
QCIAVVSLDNLLKGAAGQAVQAANKYYQLVEDTGLDTLAGMWP
CEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566