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The map label for this gene is lysK [H]

Identifier: 28377382

GI number: 28377382

Start: 435955

End: 437793

Strand: Direct

Name: lysK [H]

Synonym: lp_0488

Alternate gene names: 28377382

Gene position: 435955-437793 (Clockwise)

Preceding gene: 28377381

Following gene: 28377383

Centisome position: 13.18

GC content: 36.38

Gene sequence:

>1839_bases
ATGCAGAACATATTCGTTCTTAAGCTCGGTAGTAGTACTGTTTTACATGGAGCACAAATTTACAATCAAATTTCAGCACT
TGTAGAACAAGGTTCTAAAGTGATTATTGTAGCTGGTGGAGCTGAAGCAATTCATAAAACGTATGATAACTTAGGATTGC
CCGAAAAGTATCTAACTTTACGCCATGGTAATACAGTTAGATATACACCTGGCAAAGATATGAGCATCATTAAAAGTGCT
TATAACTCAATAATTATTCCCAAAATAGAAGACGAACTCAGTCAACGTGGCATTTCTGTTTTTAGTCAAATTGCAGGAAA
AAGCCAGTTGACTTGGGGAAAACTAGGAAAACCATTATTAGCTAATAAAAATGGCCGGAATATTGTAATTCGTGACTCAC
TGTATGGTAAATTTGCAGGTTGCGATGTTAAACAAATTTCTATGATATTAAATGCATTCTCAGTAGTTTTATTAACACCT
CCAATTTTTGAAAAAAGTGTTAATGATTATATTAATATTGATGCAGATATGCTTGCAGCAAACCTAGCTATTGAATGTAA
TGCTGCGCATCTTCGATTTGTTACTAGTACTCCAGGACTACTTTATAATGTAAATGATGTCGATAGTGGAATTCCTGATC
TCTATATCAAAGAATTAACTGATACAAGTTTTATTAAAGGCAAGATGAAGCAGAAGTTACGGGCAGTGAAGAGAGTAATG
AAACATGGTCGGTGCGACGTTGCAATTACTGGGGTACACTCCCTGGAACATAAGACTTGGGTTTGGAATTATCATCAAGC
CGATTACTATGAACAGCTTTTTACTAATATTGTCACTATTCCGTCAGTTTCTTTTGATGAACATGTGCTCGCTAACTATT
TAAATGACTTAAAAATGGCCAATATTACAAGTAACATTGATAGCGCTGGCAACATCGTTTTAAAAAAGGGTAGTGGGCAT
AAAAAGTTATTACTGTTAGGACATATAGATACTGTTCGGAATTTTTGGCAAGTCAAAATTGAAGCAGGTTCTTTAAAGGG
AAGAGGCGCGGTTGACGCTAAAGCACCATTTGCTACTTTTTTATCTGTTCTAAATAAGGTTAAGGTTCCTAGTGATTGCC
AATTAATCGTCATTGGGGCAGTCGAGGAAGAATCTTCGAGTTCAAAGGGCGCTTATCAAGTGCGTGATAACTACGAAAAA
ATGCCAGTTATTATTGGAGAGCCTAGTGGTATTGAGAAACTCACTCTTGGATATAACGGACTACTAAAGTTAAAGCTTAA
TTGTCATATGGTGCAAGGCCATTCGGCAGGTAAAGGTGCTATAAGTAGCATCGATGCTCTTATTGATTACAGTAATAAGA
TTCGCGAAATTATGGCTAATTATGATCCTAAAGGACTTTCCTCAATTCAGGATATTAGCCATAGTAAGTCTGATAATCAA
ACTGAATTACTTCTAAACTTCAGAGTAAGTAGGTATGTAAAATCCGGTTATGTTGAGGCAATAAAGAAACAAACAGATAA
GAATATTTCCTTGGAAGTGTTAAGAGATACGCCAGCGTCTACTTCAAAGCGTAGTAATCAGTTAGCTAATGCTTTTGTCT
CGGGATTTAAAGTGGTACAGAAAATGATTCCTGAATATATTGTAAAGACTGGTACTAGTGATATGAATACATTAGCAACC
CAATGGACTGTTCCAATGGTGGCATATGGTCCAGGTGACTCCACACTCGATCATACACTGCAAGAAGAAGTGCCGTTTGC
TGATTATCATCTAGGTATTCAGACATTACAAGAGGCCATCCAAACATACTTAGGCAAGGTGACAGATAATGACAAATAA

Upstream 100 bases:

>100_bases
TATTAAAAGGTGCGGCCGGTCAGGCGGTTCAAGCTGCTAATAAATACTATCAGTTAGTTGAAGATACAGGATTAGATACT
TTAGCAGGGATGTGGCCATA

Downstream 100 bases:

>100_bases
ACAGTTGTCAGTGACACAACAAAGAAAGTTATTGTTAGACTCCTTTAAAATTCGAGAAGAAATTATTGATATTGCTGCCA
CTCTAACCGGTTGTCATATT

Product: bifunctional protein: acetyl-glutamate kinase; acetyl-ornithine deacetylase (putative)

Products: ADP; N-acetyl-L-glutamate 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MQNIFVLKLGSSTVLHGAQIYNQISALVEQGSKVIIVAGGAEAIHKTYDNLGLPEKYLTLRHGNTVRYTPGKDMSIIKSA
YNSIIIPKIEDELSQRGISVFSQIAGKSQLTWGKLGKPLLANKNGRNIVIRDSLYGKFAGCDVKQISMILNAFSVVLLTP
PIFEKSVNDYINIDADMLAANLAIECNAAHLRFVTSTPGLLYNVNDVDSGIPDLYIKELTDTSFIKGKMKQKLRAVKRVM
KHGRCDVAITGVHSLEHKTWVWNYHQADYYEQLFTNIVTIPSVSFDEHVLANYLNDLKMANITSNIDSAGNIVLKKGSGH
KKLLLLGHIDTVRNFWQVKIEAGSLKGRGAVDAKAPFATFLSVLNKVKVPSDCQLIVIGAVEEESSSSKGAYQVRDNYEK
MPVIIGEPSGIEKLTLGYNGLLKLKLNCHMVQGHSAGKGAISSIDALIDYSNKIREIMANYDPKGLSSIQDISHSKSDNQ
TELLLNFRVSRYVKSGYVEAIKKQTDKNISLEVLRDTPASTSKRSNQLANAFVSGFKVVQKMIPEYIVKTGTSDMNTLAT
QWTVPMVAYGPGDSTLDHTLQEEVPFADYHLGIQTLQEAIQTYLGKVTDNDK

Sequences:

>Translated_612_residues
MQNIFVLKLGSSTVLHGAQIYNQISALVEQGSKVIIVAGGAEAIHKTYDNLGLPEKYLTLRHGNTVRYTPGKDMSIIKSA
YNSIIIPKIEDELSQRGISVFSQIAGKSQLTWGKLGKPLLANKNGRNIVIRDSLYGKFAGCDVKQISMILNAFSVVLLTP
PIFEKSVNDYINIDADMLAANLAIECNAAHLRFVTSTPGLLYNVNDVDSGIPDLYIKELTDTSFIKGKMKQKLRAVKRVM
KHGRCDVAITGVHSLEHKTWVWNYHQADYYEQLFTNIVTIPSVSFDEHVLANYLNDLKMANITSNIDSAGNIVLKKGSGH
KKLLLLGHIDTVRNFWQVKIEAGSLKGRGAVDAKAPFATFLSVLNKVKVPSDCQLIVIGAVEEESSSSKGAYQVRDNYEK
MPVIIGEPSGIEKLTLGYNGLLKLKLNCHMVQGHSAGKGAISSIDALIDYSNKIREIMANYDPKGLSSIQDISHSKSDNQ
TELLLNFRVSRYVKSGYVEAIKKQTDKNISLEVLRDTPASTSKRSNQLANAFVSGFKVVQKMIPEYIVKTGTSDMNTLAT
QWTVPMVAYGPGDSTLDHTLQEEVPFADYHLGIQTLQEAIQTYLGKVTDNDK
>Mature_612_residues
MQNIFVLKLGSSTVLHGAQIYNQISALVEQGSKVIIVAGGAEAIHKTYDNLGLPEKYLTLRHGNTVRYTPGKDMSIIKSA
YNSIIIPKIEDELSQRGISVFSQIAGKSQLTWGKLGKPLLANKNGRNIVIRDSLYGKFAGCDVKQISMILNAFSVVLLTP
PIFEKSVNDYINIDADMLAANLAIECNAAHLRFVTSTPGLLYNVNDVDSGIPDLYIKELTDTSFIKGKMKQKLRAVKRVM
KHGRCDVAITGVHSLEHKTWVWNYHQADYYEQLFTNIVTIPSVSFDEHVLANYLNDLKMANITSNIDSAGNIVLKKGSGH
KKLLLLGHIDTVRNFWQVKIEAGSLKGRGAVDAKAPFATFLSVLNKVKVPSDCQLIVIGAVEEESSSSKGAYQVRDNYEK
MPVIIGEPSGIEKLTLGYNGLLKLKLNCHMVQGHSAGKGAISSIDALIDYSNKIREIMANYDPKGLSSIQDISHSKSDNQ
TELLLNFRVSRYVKSGYVEAIKKQTDKNISLEVLRDTPASTSKRSNQLANAFVSGFKVVQKMIPEYIVKTGTSDMNTLAT
QWTVPMVAYGPGDSTLDHTLQEEVPFADYHLGIQTLQEAIQTYLGKVTDNDK

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. LysK subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010175
- InterPro:   IPR002933 [H]

Pfam domain/function: PF01546 Peptidase_M20 [H]

EC number: 2.7.2.8; 3.5.1.16

Molecular weight: Translated: 67476; Mature: 67476

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIFVLKLGSSTVLHGAQIYNQISALVEQGSKVIIVAGGAEAIHKTYDNLGLPEKYLTL
CCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHEEE
RHGNTVRYTPGKDMSIIKSAYNSIIIPKIEDELSQRGISVFSQIAGKSQLTWGKLGKPLL
ECCCEEEECCCCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCC
ANKNGRNIVIRDSLYGKFAGCDVKQISMILNAFSVVLLTPPIFEKSVNDYINIDADMLAA
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCHHHHEE
NLAIECNAAHLRFVTSTPGLLYNVNDVDSGIPDLYIKELTDTSFIKGKMKQKLRAVKRVM
EEEEEECCEEEEEEECCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
KHGRCDVAITGVHSLEHKTWVWNYHQADYYEQLFTNIVTIPSVSFDEHVLANYLNDLKMA
HCCCCCEEEECCHHCCCCEEEEECCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
NITSNIDSAGNIVLKKGSGHKKLLLLGHIDTVRNFWQVKIEAGSLKGRGAVDAKAPFATF
HHHCCCCCCCCEEEEECCCCCEEEEEECHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHH
LSVLNKVKVPSDCQLIVIGAVEEESSSSKGAYQVRDNYEKMPVIIGEPSGIEKLTLGYNG
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCEEEECCCCCEEEEECCCC
LLKLKLNCHMVQGHSAGKGAISSIDALIDYSNKIREIMANYDPKGLSSIQDISHSKSDNQ
EEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
TELLLNFRVSRYVKSGYVEAIKKQTDKNISLEVLRDTPASTSKRSNQLANAFVSGFKVVQ
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
KMIPEYIVKTGTSDMNTLATQWTVPMVAYGPGDSTLDHTLQEEVPFADYHLGIQTLQEAI
HHHHHHHHHCCCCHHHHHHHEECCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
QTYLGKVTDNDK
HHHHCCCCCCCC
>Mature Secondary Structure
MQNIFVLKLGSSTVLHGAQIYNQISALVEQGSKVIIVAGGAEAIHKTYDNLGLPEKYLTL
CCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHEEE
RHGNTVRYTPGKDMSIIKSAYNSIIIPKIEDELSQRGISVFSQIAGKSQLTWGKLGKPLL
ECCCEEEECCCCCHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCC
ANKNGRNIVIRDSLYGKFAGCDVKQISMILNAFSVVLLTPPIFEKSVNDYINIDADMLAA
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCHHHHEE
NLAIECNAAHLRFVTSTPGLLYNVNDVDSGIPDLYIKELTDTSFIKGKMKQKLRAVKRVM
EEEEEECCEEEEEEECCCCEEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHH
KHGRCDVAITGVHSLEHKTWVWNYHQADYYEQLFTNIVTIPSVSFDEHVLANYLNDLKMA
HCCCCCEEEECCHHCCCCEEEEECCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHH
NITSNIDSAGNIVLKKGSGHKKLLLLGHIDTVRNFWQVKIEAGSLKGRGAVDAKAPFATF
HHHCCCCCCCCEEEEECCCCCEEEEEECHHHHCCEEEEEEEECCCCCCCCCCCCCCHHHH
LSVLNKVKVPSDCQLIVIGAVEEESSSSKGAYQVRDNYEKMPVIIGEPSGIEKLTLGYNG
HHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCEEEECCCCCEEEEECCCC
LLKLKLNCHMVQGHSAGKGAISSIDALIDYSNKIREIMANYDPKGLSSIQDISHSKSDNQ
EEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
TELLLNFRVSRYVKSGYVEAIKKQTDKNISLEVLRDTPASTSKRSNQLANAFVSGFKVVQ
EEEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
KMIPEYIVKTGTSDMNTLATQWTVPMVAYGPGDSTLDHTLQEEVPFADYHLGIQTLQEAI
HHHHHHHHHCCCCHHHHHHHEECCCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHH
QTYLGKVTDNDK
HHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-acetyl-L-glutamate

Specific reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]