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The map label for this gene is coaBC [H]

Identifier: 28210905

GI number: 28210905

Start: 1303573

End: 1304766

Strand: Direct

Name: coaBC [H]

Synonym: CTC01217

Alternate gene names: 28210905

Gene position: 1303573-1304766 (Clockwise)

Preceding gene: 28210904

Following gene: 28210906

Centisome position: 46.57

GC content: 30.74

Gene sequence:

>1194_bases
ATGAATAAAAAAAACATAGTTATAGGTGTTACAGGAGGAATAGCAGTATATAAGGCTTTAGAAGTAATAAGCAAGCTAAA
GAAAAAGAATTTTAATATAGATGTTATTATGACAAAATCCGCCTGTGAATTTGTAACTCCTTTAAGCTTTCAAAGCTTAA
GTCAAAATATGGTTGTTACAGATATGTTTGATGAACCAAAACATTGGGAAATTCAGCACATATCACTGGCAAAAAAAGCA
GATCTTATACTTATAGTGCCAGCTACAGCGAATATAATAGGAAAAGTTGCCAATGGAATAGCAGATGATATGCTATCTAC
TACTATAATGGCAACTAGAGCACCAGTGGTTTTTGCTAGTGCCATGAATACAAATATGTATACCAATCCAATAGTGCAAC
AAAATATAGAAAAATTAAAATCCTTTGGATATAGTTTTATAGAACCAACATCAGGTATGTTAGCCTGTGGTGATAGTGGT
AAAGGAAAATTGGCTGATACAGAACTTATAGCAAATATAGCAGAAAGTATGCTTTATCCAAAAAAAGATTTAATAGGAAA
GAAGGTTCTAGTAACAGCAGGACCTACAAAAGCTCCAATTGATCCCGTTAGATATGTTACAAACAAATCAACTGGGAAAA
TGGGTTATGAAATAGCTAAAGAAGCCAGAGATAGGGGAGCAGATGTAACTTTAATATCTGGAACTTCAAATTTGCAAGAT
CCTTTTGGAATTAATACCATTCATATTAATACAAATGAAGAAATGCTAAAAGAAGTATTAGATAATTTTCAAAAACAAGA
TATTGTAATAAAGGCAGCAGCCGTTGCAGACTATAAACCTAAGACCTTTTCTGATAAGAAAATAAAAAAGAAAGATGGAG
AAGGTTTAAACTTAGAAATGGAAAAGGATACAGATATATTAAGAGAACTTGGCAGTATAAAGAAAAATCAAGTACTAGTT
GGATTTGCGGCAGAAAGTAATGATTTAATTGAAAACGCCACAGAAAAGCTTAAGAAGAAAAATTTAGATTATATAGTTGC
AAATGATATAACAGGTCATGGAATTGGATTTGCGTCTGATGATAATAAAGTAAATATACTGTGTAGAAATGGAAACAATA
TTTCATTAGACAAAATGAGTAAAAAAGAAGTAGCAAGAGAAATTTTTGATTTAATATTAAAAGAGAAATTCTAA

Upstream 100 bases:

>100_bases
TTTTAGAATCAGATATAGTAAAACCTGTATCTTTAGCTATTGAAGAAGTTAATGATGGGCTTATATCCTATGAGACTATT
AGGGAAGGAATAAAATAGAT

Downstream 100 bases:

>100_bases
AAAAGTGCAGGGCACTTTTTTAGTGAATTTAAAAGGGGCTAAAGTAAGCCTCTTTTGTTTAATGATAAAAAGGGTGATAA
AGTGTATAGATATGCAGGTG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MNKKNIVIGVTGGIAVYKALEVISKLKKKNFNIDVIMTKSACEFVTPLSFQSLSQNMVVTDMFDEPKHWEIQHISLAKKA
DLILIVPATANIIGKVANGIADDMLSTTIMATRAPVVFASAMNTNMYTNPIVQQNIEKLKSFGYSFIEPTSGMLACGDSG
KGKLADTELIANIAESMLYPKKDLIGKKVLVTAGPTKAPIDPVRYVTNKSTGKMGYEIAKEARDRGADVTLISGTSNLQD
PFGINTIHINTNEEMLKEVLDNFQKQDIVIKAAAVADYKPKTFSDKKIKKKDGEGLNLEMEKDTDILRELGSIKKNQVLV
GFAAESNDLIENATEKLKKKNLDYIVANDITGHGIGFASDDNKVNILCRNGNNISLDKMSKKEVAREIFDLILKEKF

Sequences:

>Translated_397_residues
MNKKNIVIGVTGGIAVYKALEVISKLKKKNFNIDVIMTKSACEFVTPLSFQSLSQNMVVTDMFDEPKHWEIQHISLAKKA
DLILIVPATANIIGKVANGIADDMLSTTIMATRAPVVFASAMNTNMYTNPIVQQNIEKLKSFGYSFIEPTSGMLACGDSG
KGKLADTELIANIAESMLYPKKDLIGKKVLVTAGPTKAPIDPVRYVTNKSTGKMGYEIAKEARDRGADVTLISGTSNLQD
PFGINTIHINTNEEMLKEVLDNFQKQDIVIKAAAVADYKPKTFSDKKIKKKDGEGLNLEMEKDTDILRELGSIKKNQVLV
GFAAESNDLIENATEKLKKKNLDYIVANDITGHGIGFASDDNKVNILCRNGNNISLDKMSKKEVAREIFDLILKEKF
>Mature_397_residues
MNKKNIVIGVTGGIAVYKALEVISKLKKKNFNIDVIMTKSACEFVTPLSFQSLSQNMVVTDMFDEPKHWEIQHISLAKKA
DLILIVPATANIIGKVANGIADDMLSTTIMATRAPVVFASAMNTNMYTNPIVQQNIEKLKSFGYSFIEPTSGMLACGDSG
KGKLADTELIANIAESMLYPKKDLIGKKVLVTAGPTKAPIDPVRYVTNKSTGKMGYEIAKEARDRGADVTLISGTSNLQD
PFGINTIHINTNEEMLKEVLDNFQKQDIVIKAAAVADYKPKTFSDKKIKKKDGEGLNLEMEKDTDILRELGSIKKNQVLV
GFAAESNDLIENATEKLKKKNLDYIVANDITGHGIGFASDDNKVNILCRNGNNISLDKMSKKEVAREIFDLILKEKF

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=34.3915343915344, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI87082301, Length=389, Percent_Identity=40.6169665809769, Blast_Score=285, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=188, Percent_Identity=35.1063829787234, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322762, Length=195, Percent_Identity=31.7948717948718, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24657262, Length=191, Percent_Identity=33.5078534031414, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43629; Mature: 43629

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNIVIGVTGGIAVYKALEVISKLKKKNFNIDVIMTKSACEFVTPLSFQSLSQNMVVT
CCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCHHHHCCCEEEE
DMFDEPKHWEIQHISLAKKADLILIVPATANIIGKVANGIADDMLSTTIMATRAPVVFAS
ECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AMNTNMYTNPIVQQNIEKLKSFGYSFIEPTSGMLACGDSGKGKLADTELIANIAESMLYP
ECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCC
KKDLIGKKVLVTAGPTKAPIDPVRYVTNKSTGKMGYEIAKEARDRGADVTLISGTSNLQD
CHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
PFGINTIHINTNEEMLKEVLDNFQKQDIVIKAAAVADYKPKTFSDKKIKKKDGEGLNLEM
CCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHCCCCCCCEEEE
EKDTDILRELGSIKKNQVLVGFAAESNDLIENATEKLKKKNLDYIVANDITGHGIGFASD
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCC
DNKVNILCRNGNNISLDKMSKKEVAREIFDLILKEKF
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKKNIVIGVTGGIAVYKALEVISKLKKKNFNIDVIMTKSACEFVTPLSFQSLSQNMVVT
CCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCHHHHCCCEEEE
DMFDEPKHWEIQHISLAKKADLILIVPATANIIGKVANGIADDMLSTTIMATRAPVVFAS
ECCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AMNTNMYTNPIVQQNIEKLKSFGYSFIEPTSGMLACGDSGKGKLADTELIANIAESMLYP
ECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCC
KKDLIGKKVLVTAGPTKAPIDPVRYVTNKSTGKMGYEIAKEARDRGADVTLISGTSNLQD
CHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
PFGINTIHINTNEEMLKEVLDNFQKQDIVIKAAAVADYKPKTFSDKKIKKKDGEGLNLEM
CCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHCCCCCCCEEEE
EKDTDILRELGSIKKNQVLVGFAAESNDLIENATEKLKKKNLDYIVANDITGHGIGFASD
CCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCEECCC
DNKVNILCRNGNNISLDKMSKKEVAREIFDLILKEKF
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]