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The map label for this gene is gmk

Identifier: 28210904

GI number: 28210904

Start: 1302745

End: 1303371

Strand: Direct

Name: gmk

Synonym: CTC01216

Alternate gene names: 28210904

Gene position: 1302745-1303371 (Clockwise)

Preceding gene: 161486844

Following gene: 28210905

Centisome position: 46.54

GC content: 29.35

Gene sequence:

>627_bases
ATGGAAAAAGGCTTGCTAATTGTAATCTCAGGACCTTCAGGCACAGGAAAAGGAACAGTTTGCAAAGAACTTTTGAGAAA
CAATAATTTTTGGTTTTCAGTTTCCTCAACTACTAGAGATCCAAGAGAAGGAGAAATCCAGGGTAAGAGTTATTACTTCA
TGTCTAAAGAAGAATTTGAAGACAAGATTAAAGAAAATGATTTTTTAGAATATGCTAAAGTATATGGTAACTATTATGGA
ACTCCTAAATCAAAAGTAATAGAAATGCTAGATAAAGGGAAAGATGTAATACTAGAAATAGACATACAAGGGGCTTTACA
AGTAAAAGAAAATTATAAAGAAGGAATATTTATATTTATATTGCCACCTTCTATGGAGGAATTAAAAAATAGAATAATAA
AAAGAGGAACAGAAACAGAAGAATCTCTTATGACCAGATTTAAATCAGCATATAAAGAAATTAACTATGTATCAAAATAT
AATTATGCTGTTGTAAATGATAAAGTACATGATGCAGTCGAAAAAATACAAAGTATTATTTCGGCTGAAAAATGCAGAGT
GGACAGAATAAAAGACTCAATATTACTTTCTAAGGAGGGAATAATACATGAACAACTCTATGATTAA

Upstream 100 bases:

>100_bases
TAACTGATAGTGACCACGTAATACTATCTGCAGTCCAACCAGAAACAGTGGCTCATAGACTATCATATAAAGAAGATATA
TTAGAAGAGGATGAAGACTA

Downstream 100 bases:

>100_bases
TCCTGCTATAACGGATTTACTAAAAAAAGTAGATAATAGATATTCACTAGTAGTAGTAACATCCAAAAGAGCAAGGCAAC
TAGTAGATGGAGATGAAGCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MEKGLLIVISGPSGTGKGTVCKELLRNNNFWFSVSSTTRDPREGEIQGKSYYFMSKEEFEDKIKENDFLEYAKVYGNYYG
TPKSKVIEMLDKGKDVILEIDIQGALQVKENYKEGIFIFILPPSMEELKNRIIKRGTETEESLMTRFKSAYKEINYVSKY
NYAVVNDKVHDAVEKIQSIISAEKCRVDRIKDSILLSKEGIIHEQLYD

Sequences:

>Translated_208_residues
MEKGLLIVISGPSGTGKGTVCKELLRNNNFWFSVSSTTRDPREGEIQGKSYYFMSKEEFEDKIKENDFLEYAKVYGNYYG
TPKSKVIEMLDKGKDVILEIDIQGALQVKENYKEGIFIFILPPSMEELKNRIIKRGTETEESLMTRFKSAYKEINYVSKY
NYAVVNDKVHDAVEKIQSIISAEKCRVDRIKDSILLSKEGIIHEQLYD
>Mature_208_residues
MEKGLLIVISGPSGTGKGTVCKELLRNNNFWFSVSSTTRDPREGEIQGKSYYFMSKEEFEDKIKENDFLEYAKVYGNYYG
TPKSKVIEMLDKGKDVILEIDIQGALQVKENYKEGIFIFILPPSMEELKNRIIKRGTETEESLMTRFKSAYKEINYVSKY
NYAVVNDKVHDAVEKIQSIISAEKCRVDRIKDSILLSKEGIIHEQLYD

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=37.2340425531915, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=37.2340425531915, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=37.2340425531915, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI14780902, Length=191, Percent_Identity=29.3193717277487, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=30.635838150289, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=30.635838150289, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=30.635838150289, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=30.635838150289, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=26.8156424581006, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI21361598, Length=192, Percent_Identity=28.125, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4557529, Length=181, Percent_Identity=30.3867403314917, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI192447426, Length=181, Percent_Identity=30.3867403314917, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI148539628, Length=160, Percent_Identity=32.5, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI148539578, Length=160, Percent_Identity=32.5, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=40.7216494845361, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=43.0232558139535, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=43.0232558139535, Blast_Score=140, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71984092, Length=182, Percent_Identity=29.1208791208791, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71988041, Length=177, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988048, Length=127, Percent_Identity=30.7086614173228, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17557440, Length=136, Percent_Identity=28.6764705882353, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=46.9945355191257, Blast_Score=155, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21356141, Length=152, Percent_Identity=45.3947368421053, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=34.6456692913386, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=34.6456692913386, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45551002, Length=127, Percent_Identity=34.6456692913386, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45554481, Length=179, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640542, Length=179, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077626, Length=179, Percent_Identity=24.0223463687151, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_CLOTE (Q895Q5)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781848.1
- ProteinModelPortal:   Q895Q5
- SMR:   Q895Q5
- GeneID:   1059280
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC01216
- NMPDR:   fig|212717.1.peg.1070
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q895Q5
- ProtClustDB:   PRK00300
- BioCyc:   CTET212717:CTC_01216-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23982; Mature: 23982

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKGLLIVISGPSGTGKGTVCKELLRNNNFWFSVSSTTRDPREGEIQGKSYYFMSKEEFE
CCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHH
DKIKENDFLEYAKVYGNYYGTPKSKVIEMLDKGKDVILEIDIQGALQVKENYKEGIFIFI
HHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCEEEEE
LPPSMEELKNRIIKRGTETEESLMTRFKSAYKEINYVSKYNYAVVNDKVHDAVEKIQSII
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHH
SAEKCRVDRIKDSILLSKEGIIHEQLYD
HHHHHHHHHHHHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MEKGLLIVISGPSGTGKGTVCKELLRNNNFWFSVSSTTRDPREGEIQGKSYYFMSKEEFE
CCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHH
DKIKENDFLEYAKVYGNYYGTPKSKVIEMLDKGKDVILEIDIQGALQVKENYKEGIFIFI
HHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCEEEEE
LPPSMEELKNRIIKRGTETEESLMTRFKSAYKEINYVSKYNYAVVNDKVHDAVEKIQSII
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHH
SAEKCRVDRIKDSILLSKEGIIHEQLYD
HHHHHHHHHHHHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129