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The map label for this gene is cdr [H]

Identifier: 28210870

GI number: 28210870

Start: 1257997

End: 1259712

Strand: Direct

Name: cdr [H]

Synonym: CTC01178

Alternate gene names: 28210870

Gene position: 1257997-1259712 (Clockwise)

Preceding gene: 28210868

Following gene: 28210871

Centisome position: 44.94

GC content: 33.57

Gene sequence:

>1716_bases
ATGGAGGGATATGCCATGAGTAAAAAATATTTAATAGTAGGTGGAGTTGCCGGAGGTGCGTCCACAGCAGCAAGATTAAG
AAGACTTAGTGAAGAAGACGAAATAATAATGTTTGAAAGAGGTCCTCACGTATCATTTTCAAACTGTTGTCTACCATATC
ACTTAGCTGGATTAATTAAAACAGCTAACCAACTAGTACTTATGTCACCAGAACAATTTAAAAAACAATACAATATCGAA
GCTAGAGTAAACAGCGAAGTTATCGATATAGATAGAGCTAAAAAAGAAATAACAATTAAAGATACATTAACTGGAAAAGA
ATACACTGAAAACTATGATAAATTAATATTATCACCAGGTGCAAAACCAATAGTTCCACCAATTAAAGGAATTGAAGACA
TAAACTTATTCACAGTAAGAAACGTTATAGATATAGATAAATTAAACAAATTCGTAAGCACTATGAAAACTAAAAACGCT
ACAGTAGTAGGTGGAGGATTCATAGGAATCGAAGTTGCAGAAAACTTAAAAGAAGCTGGATTTAACGTAACTTTAGTAGA
AGCTATGCCCCAAGTTATGAAAATATTTGACTATGACATGGTTCAAATTCTACACAAAGAATTACACGATAAAGGAATAA
ATTTAATCGTTAACGATAAAGTAGCTTCATTTGAAAAAGATACAGTTGTATTAGAATCAGGAAAGAGAGTTGAAGCTGAA
GCTGTAGTTATGGCTATAGGTGTTACTCCAGAAACAGATCTTGCAGTAAAAGCTGGTCTTGAACTTGGAGAATTAGGAGG
AATAAAAGTAGACCAAAACTACAGAACTAAAGATGAAGATGTTTATGCAGTAGGGGATGCTATTGAAGTATACCATGCAT
TAACTGGAAAAATGACTAAACTTCCATTAGCAGGACCTGCACAAAAACAAGCAAGAGAAGTTGCTGACCATATCCACGGA
AGATTAGTACCAAACACAGGATATATTGGATCATCAGTAGTAAAATGTTTTGAATATAATGGAGCTTCCACAGGACTAAA
CGAAGGAATGATAAAAGCTCTTAACTTAGATATACAATATGAAACAGTTAAAGTAATCCCTGGAGACAAGGTTGGATTAA
TGCCAGGATGTGAACCACTTCACTTCAAGTTATTATTTGAAATACCAACTGGAAAAATATTAGGAGCTCAAGCAATAGGT
AGAGGAAACGTAGATAAGAGAGTAGACGTTATAGCTACAGCTATCAAATTTGGAGCAACTATAAACGATCTAAGAGATCT
AGAATTCTGTTATGCACCACCATTTGGAACAGCTAAAGACGTTGTTAACTTTGCAGGATACGTTGGATCAAACTTATTAC
ACGATGAGTTCAAACAAGTTCATGAATATGATGTAAGAGATTTAGTTGAAAGTGGGGCTTGCATAATAGACGTAAGAGAA
AAACACGAATATGAATTAAGCCACATAATCGGAGCTAAAAACATACCTTTAAGTGAAATAAGAGATAGAGTAGCTGAAAT
TCCAAAGGATCAACCAGTTTACTTACACTGTAGAAGTGCTCAAAGAAGTTACAATGCAGCAAAAGCATTAAAACATTTAG
GATTTGATAACATTTATAATGTATCTGGTGGATTTATGGGAATATCCTTCTATGAATATTTCAATGATCAAACAACAGGA
AGAGAAAAAATAGTTACAGACTACAATTTCTTATAA

Upstream 100 bases:

>100_bases
AATGATTGTAAAACTGCAGTTACAATTGCAATTATTTCTGTAAATGTTTTAGATTTGTTTATTTTATAATTTACAAAAAA
ATATAGCATTAAATAATATA

Downstream 100 bases:

>100_bases
TATTAAAAAATAGGGGCTTTAATTGCCCCTTTTATATGAAATAATAATGAGAATAGGAAGTGAGCAAGGTATTATGAGTA
AAAAGGAGACATCTGGATTA

Product: NADH oxidase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 571; Mature: 571

Protein sequence:

>571_residues
MEGYAMSKKYLIVGGVAGGASTAARLRRLSEEDEIIMFERGPHVSFSNCCLPYHLAGLIKTANQLVLMSPEQFKKQYNIE
ARVNSEVIDIDRAKKEITIKDTLTGKEYTENYDKLILSPGAKPIVPPIKGIEDINLFTVRNVIDIDKLNKFVSTMKTKNA
TVVGGGFIGIEVAENLKEAGFNVTLVEAMPQVMKIFDYDMVQILHKELHDKGINLIVNDKVASFEKDTVVLESGKRVEAE
AVVMAIGVTPETDLAVKAGLELGELGGIKVDQNYRTKDEDVYAVGDAIEVYHALTGKMTKLPLAGPAQKQAREVADHIHG
RLVPNTGYIGSSVVKCFEYNGASTGLNEGMIKALNLDIQYETVKVIPGDKVGLMPGCEPLHFKLLFEIPTGKILGAQAIG
RGNVDKRVDVIATAIKFGATINDLRDLEFCYAPPFGTAKDVVNFAGYVGSNLLHDEFKQVHEYDVRDLVESGACIIDVRE
KHEYELSHIIGAKNIPLSEIRDRVAEIPKDQPVYLHCRSAQRSYNAAKALKHLGFDNIYNVSGGFMGISFYEYFNDQTTG
REKIVTDYNFL

Sequences:

>Translated_571_residues
MEGYAMSKKYLIVGGVAGGASTAARLRRLSEEDEIIMFERGPHVSFSNCCLPYHLAGLIKTANQLVLMSPEQFKKQYNIE
ARVNSEVIDIDRAKKEITIKDTLTGKEYTENYDKLILSPGAKPIVPPIKGIEDINLFTVRNVIDIDKLNKFVSTMKTKNA
TVVGGGFIGIEVAENLKEAGFNVTLVEAMPQVMKIFDYDMVQILHKELHDKGINLIVNDKVASFEKDTVVLESGKRVEAE
AVVMAIGVTPETDLAVKAGLELGELGGIKVDQNYRTKDEDVYAVGDAIEVYHALTGKMTKLPLAGPAQKQAREVADHIHG
RLVPNTGYIGSSVVKCFEYNGASTGLNEGMIKALNLDIQYETVKVIPGDKVGLMPGCEPLHFKLLFEIPTGKILGAQAIG
RGNVDKRVDVIATAIKFGATINDLRDLEFCYAPPFGTAKDVVNFAGYVGSNLLHDEFKQVHEYDVRDLVESGACIIDVRE
KHEYELSHIIGAKNIPLSEIRDRVAEIPKDQPVYLHCRSAQRSYNAAKALKHLGFDNIYNVSGGFMGISFYEYFNDQTTG
REKIVTDYNFL
>Mature_571_residues
MEGYAMSKKYLIVGGVAGGASTAARLRRLSEEDEIIMFERGPHVSFSNCCLPYHLAGLIKTANQLVLMSPEQFKKQYNIE
ARVNSEVIDIDRAKKEITIKDTLTGKEYTENYDKLILSPGAKPIVPPIKGIEDINLFTVRNVIDIDKLNKFVSTMKTKNA
TVVGGGFIGIEVAENLKEAGFNVTLVEAMPQVMKIFDYDMVQILHKELHDKGINLIVNDKVASFEKDTVVLESGKRVEAE
AVVMAIGVTPETDLAVKAGLELGELGGIKVDQNYRTKDEDVYAVGDAIEVYHALTGKMTKLPLAGPAQKQAREVADHIHG
RLVPNTGYIGSSVVKCFEYNGASTGLNEGMIKALNLDIQYETVKVIPGDKVGLMPGCEPLHFKLLFEIPTGKILGAQAIG
RGNVDKRVDVIATAIKFGATINDLRDLEFCYAPPFGTAKDVVNFAGYVGSNLLHDEFKQVHEYDVRDLVESGACIIDVRE
KHEYELSHIIGAKNIPLSEIRDRVAEIPKDQPVYLHCRSAQRSYNAAKALKHLGFDNIYNVSGGFMGISFYEYFNDQTTG
REKIVTDYNFL

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=363, Percent_Identity=28.099173553719, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI226437568, Length=363, Percent_Identity=28.099173553719, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI65787454, Length=363, Percent_Identity=28.099173553719, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1789065, Length=276, Percent_Identity=27.1739130434783, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1789765, Length=296, Percent_Identity=28.0405405405405, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788892, Length=283, Percent_Identity=25.0883392226148, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786307, Length=333, Percent_Identity=26.4264264264264, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082354, Length=292, Percent_Identity=25.6849315068493, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17559934, Length=234, Percent_Identity=26.0683760683761, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24585130, Length=331, Percent_Identity=22.9607250755287, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281359715, Length=328, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281359713, Length=328, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639250, Length=328, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI18543267, Length=328, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639252, Length=328, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639257, Length=328, Percent_Identity=24.390243902439, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 63048; Mature: 63048

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGYAMSKKYLIVGGVAGGASTAARLRRLSEEDEIIMFERGPHVSFSNCCLPYHLAGLIK
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
TANQLVLMSPEQFKKQYNIEARVNSEVIDIDRAKKEITIKDTLTGKEYTENYDKLILSPG
CCCCEEEECHHHHHHHCCCEEEECCEEEECCCCCCEEEEEECCCCCHHHCCCCEEEECCC
AKPIVPPIKGIEDINLFTVRNVIDIDKLNKFVSTMKTKNATVVGGGFIGIEVAENLKEAG
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCEEEHHHHHHHHHCC
FNVTLVEAMPQVMKIFDYDMVQILHKELHDKGINLIVNDKVASFEKDTVVLESGKRVEAE
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCEEEECCCCEEEEE
AVVMAIGVTPETDLAVKAGLELGELGGIKVDQNYRTKDEDVYAVGDAIEVYHALTGKMTK
EEEEEEECCCCCCHHHHCCCCCCCCCCEEECCCCCCCCCCEEEECHHHHHHHHHHCCCEE
LPLAGPAQKQAREVADHIHGRLVPNTGYIGSSVVKCFEYNGASTGLNEGMIKALNLDIQY
CCCCCCHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEE
ETVKVIPGDKVGLMPGCEPLHFKLLFEIPTGKILGAQAIGRGNVDKRVDVIATAIKFGAT
EEEEEECCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCC
INDLRDLEFCYAPPFGTAKDVVNFAGYVGSNLLHDEFKQVHEYDVRDLVESGACIIDVRE
HHHHHCCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
KHEYELSHIIGAKNIPLSEIRDRVAEIPKDQPVYLHCRSAQRSYNAAKALKHLGFDNIYN
CCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEE
VSGGFMGISFYEYFNDQTTGREKIVTDYNFL
CCCCEEEEEHHHHHCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MEGYAMSKKYLIVGGVAGGASTAARLRRLSEEDEIIMFERGPHVSFSNCCLPYHLAGLIK
CCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHH
TANQLVLMSPEQFKKQYNIEARVNSEVIDIDRAKKEITIKDTLTGKEYTENYDKLILSPG
CCCCEEEECHHHHHHHCCCEEEECCEEEECCCCCCEEEEEECCCCCHHHCCCCEEEECCC
AKPIVPPIKGIEDINLFTVRNVIDIDKLNKFVSTMKTKNATVVGGGFIGIEVAENLKEAG
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCEEEHHHHHHHHHCC
FNVTLVEAMPQVMKIFDYDMVQILHKELHDKGINLIVNDKVASFEKDTVVLESGKRVEAE
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHCCCCCEEEECCCCEEEEE
AVVMAIGVTPETDLAVKAGLELGELGGIKVDQNYRTKDEDVYAVGDAIEVYHALTGKMTK
EEEEEEECCCCCCHHHHCCCCCCCCCCEEECCCCCCCCCCEEEECHHHHHHHHHHCCCEE
LPLAGPAQKQAREVADHIHGRLVPNTGYIGSSVVKCFEYNGASTGLNEGMIKALNLDIQY
CCCCCCHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEE
ETVKVIPGDKVGLMPGCEPLHFKLLFEIPTGKILGAQAIGRGNVDKRVDVIATAIKFGAT
EEEEEECCCCCCCCCCCCCEEEEEEEECCCCCEECCCCCCCCCCCHHHHHHHHHHHHCCC
INDLRDLEFCYAPPFGTAKDVVNFAGYVGSNLLHDEFKQVHEYDVRDLVESGACIIDVRE
HHHHHCCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
KHEYELSHIIGAKNIPLSEIRDRVAEIPKDQPVYLHCRSAQRSYNAAKALKHLGFDNIYN
CCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEE
VSGGFMGISFYEYFNDQTTGREKIVTDYNFL
CCCCEEEEEHHHHHCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA