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The map label for this gene is yeiA [H]

Identifier: 28210533

GI number: 28210533

Start: 863414

End: 864649

Strand: Direct

Name: yeiA [H]

Synonym: CTC00816

Alternate gene names: 28210533

Gene position: 863414-864649 (Clockwise)

Preceding gene: 28210532

Following gene: 28210535

Centisome position: 30.84

GC content: 32.61

Gene sequence:

>1236_bases
ATGAAAAAAGTAGATTTATCCATTGAATTTTGTGGGGTGAAATGTGAAAATCCATTTTTCTTATCATCTTCTCCTGTTGG
ACACAATTATGAAATGTGTGCTAAGGCCTTGGAAACTGGATGGGGAGGAGTAGTGTTTAAAACCATAGGATTTTATTTAC
CAGAGGAAGTTTCTCCAAGATTTGATAATTTAAGAAAGGAAAGCACATCTTTTTTAGGATTTAAAAATATGGAGCAAATA
GCAGAATATCCATTAGAATATAATCTAGAGCAGATCAGAAAAATAAAAAAGAATTATCCTTCAAAGGTTCTTATAGCTTC
TATAATGGGAGAAAATGAAAAAGAATGGACAGAACTTGCTAAAATGGTAACAGAGGCAGGAGCTGATATTATAGAGTGTA
ACTATTCTTGTCCACAAATGGCTAGTGGTGCTATGGGATCAGATGTTGGACAAAGTCCAGAACTAGTAAAAAAATATTCT
AGGGCAACTAGAAAAGGTAGTAAACTTCCTATACTTGCTAAAATGACTCCTAATATTGGACATATGGAGATACCAGCTAT
TGCTTCCATTGAAGGGGGAGCTACAGGTATTGCGGCTATAAATACTATAAAGTGTATTACAGGAATAAATTTAGATAATC
AAATATCTCTTCCAATAGTGAATGGAAAATCGTCTATATCAGGATATTCAGGTAAAGCTATAAAACCAATAGCTTTAAGA
TTTATAGCACAAATGAGTCAAAATGAGAAATTGAAAGGCGTGCCAATTAGTGGTATAGGGGGAATAGAAACTTGGGAAGA
CGCACTAGAATTTATAATGCTTGGAGCTAGAAATGTTCAAGTAACTACAGCCATTATGCAATATGGATATAGAATAGTAA
AAGATATGATAAAAGGAGTATCTTATTATATGGAAGAAAAGGGATTTAATAATTTAGAAGAGCTTGTTGGTATAGCATTA
AATAATTTAATTCCAGCAGAAGAATTAGATAGAGGATATATAGTTTACCCTAATTTTCATGAGGAAAAATGTATAGGATG
TGGAAGATGCTATATCTCTTGCTATGATGGAGGACATCAAGCTATAGAATGGAATACTGAAGAAAGAACAGTAAAGTTAA
ATAAGGAAAAATGTGTGGGATGTCATCTATGTTCTAATGTCTGCCCAGTGCAGTGTATAGATTATGGAGAAATAGAATTT
AAAGAAGGTAACAAAGAAAGAGAAGTAATTTTATAA

Upstream 100 bases:

>100_bases
TTATAAAAGGAAATAAAACAGTAGTGGATGCAGTTGCAACGGGTAAAAGAGTTGCTATAGAAATAGAAGAATATATAAGA
AGAAAGGGAGATGTTAGGTA

Downstream 100 bases:

>100_bases
TGGATGATTAACAATGAACAATGAATAACATATGGATATTTTTCTTTGTTTTACTCTGAAAAGTTTTAAATTTAAGTTTG
TTAAGCTGAAGTTTAATATG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MKKVDLSIEFCGVKCENPFFLSSSPVGHNYEMCAKALETGWGGVVFKTIGFYLPEEVSPRFDNLRKESTSFLGFKNMEQI
AEYPLEYNLEQIRKIKKNYPSKVLIASIMGENEKEWTELAKMVTEAGADIIECNYSCPQMASGAMGSDVGQSPELVKKYS
RATRKGSKLPILAKMTPNIGHMEIPAIASIEGGATGIAAINTIKCITGINLDNQISLPIVNGKSSISGYSGKAIKPIALR
FIAQMSQNEKLKGVPISGIGGIETWEDALEFIMLGARNVQVTTAIMQYGYRIVKDMIKGVSYYMEEKGFNNLEELVGIAL
NNLIPAEELDRGYIVYPNFHEEKCIGCGRCYISCYDGGHQAIEWNTEERTVKLNKEKCVGCHLCSNVCPVQCIDYGEIEF
KEGNKEREVIL

Sequences:

>Translated_411_residues
MKKVDLSIEFCGVKCENPFFLSSSPVGHNYEMCAKALETGWGGVVFKTIGFYLPEEVSPRFDNLRKESTSFLGFKNMEQI
AEYPLEYNLEQIRKIKKNYPSKVLIASIMGENEKEWTELAKMVTEAGADIIECNYSCPQMASGAMGSDVGQSPELVKKYS
RATRKGSKLPILAKMTPNIGHMEIPAIASIEGGATGIAAINTIKCITGINLDNQISLPIVNGKSSISGYSGKAIKPIALR
FIAQMSQNEKLKGVPISGIGGIETWEDALEFIMLGARNVQVTTAIMQYGYRIVKDMIKGVSYYMEEKGFNNLEELVGIAL
NNLIPAEELDRGYIVYPNFHEEKCIGCGRCYISCYDGGHQAIEWNTEERTVKLNKEKCVGCHLCSNVCPVQCIDYGEIEF
KEGNKEREVIL
>Mature_411_residues
MKKVDLSIEFCGVKCENPFFLSSSPVGHNYEMCAKALETGWGGVVFKTIGFYLPEEVSPRFDNLRKESTSFLGFKNMEQI
AEYPLEYNLEQIRKIKKNYPSKVLIASIMGENEKEWTELAKMVTEAGADIIECNYSCPQMASGAMGSDVGQSPELVKKYS
RATRKGSKLPILAKMTPNIGHMEIPAIASIEGGATGIAAINTIKCITGINLDNQISLPIVNGKSSISGYSGKAIKPIALR
FIAQMSQNEKLKGVPISGIGGIETWEDALEFIMLGARNVQVTTAIMQYGYRIVKDMIKGVSYYMEEKGFNNLEELVGIAL
NNLIPAEELDRGYIVYPNFHEEKCIGCGRCYISCYDGGHQAIEWNTEERTVKLNKEKCVGCHLCSNVCPVQCIDYGEIEF
KEGNKEREVIL

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=327, Percent_Identity=34.8623853211009, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI87082059, Length=411, Percent_Identity=68.6131386861314, Blast_Score=601, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI71984108, Length=329, Percent_Identity=38.6018237082067, Blast_Score=211, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322633, Length=237, Percent_Identity=24.8945147679325, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640763, Length=307, Percent_Identity=39.413680781759, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI18858217, Length=307, Percent_Identity=39.413680781759, Blast_Score=204, Evalue=6e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 45568; Mature: 45568

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVDLSIEFCGVKCENPFFLSSSPVGHNYEMCAKALETGWGGVVFKTIGFYLPEEVSPR
CCEEEEEEEEECEEECCCEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
FDNLRKESTSFLGFKNMEQIAEYPLEYNLEQIRKIKKNYPSKVLIASIMGENEKEWTELA
HHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHH
KMVTEAGADIIECNYSCPQMASGAMGSDVGQSPELVKKYSRATRKGSKLPILAKMTPNIG
HHHHHCCCCEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
HMEIPAIASIEGGATGIAAINTIKCITGINLDNQISLPIVNGKSSISGYSGKAIKPIALR
CEECCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
FIAQMSQNEKLKGVPISGIGGIETWEDALEFIMLGARNVQVTTAIMQYGYRIVKDMIKGV
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SYYMEEKGFNNLEELVGIALNNLIPAEELDRGYIVYPNFHEEKCIGCGRCYISCYDGGHQ
HHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCEEECCCCCCHHHCCCCEEEEEEECCCCE
AIEWNTEERTVKLNKEKCVGCHLCSNVCPVQCIDYGEIEFKEGNKEREVIL
EEEECCCCCEEEECHHHHHHHHHHCCCCCEEEECCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MKKVDLSIEFCGVKCENPFFLSSSPVGHNYEMCAKALETGWGGVVFKTIGFYLPEEVSPR
CCEEEEEEEEECEEECCCEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCH
FDNLRKESTSFLGFKNMEQIAEYPLEYNLEQIRKIKKNYPSKVLIASIMGENEKEWTELA
HHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHH
KMVTEAGADIIECNYSCPQMASGAMGSDVGQSPELVKKYSRATRKGSKLPILAKMTPNIG
HHHHHCCCCEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCC
HMEIPAIASIEGGATGIAAINTIKCITGINLDNQISLPIVNGKSSISGYSGKAIKPIALR
CEECCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
FIAQMSQNEKLKGVPISGIGGIETWEDALEFIMLGARNVQVTTAIMQYGYRIVKDMIKGV
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SYYMEEKGFNNLEELVGIALNNLIPAEELDRGYIVYPNFHEEKCIGCGRCYISCYDGGHQ
HHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCEEECCCCCCHHHCCCCEEEEEEECCCCE
AIEWNTEERTVKLNKEKCVGCHLCSNVCPVQCIDYGEIEFKEGNKEREVIL
EEEECCCCCEEEECHHHHHHHHHHCCCCCEEEECCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]