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The map label for this gene is hisE

Identifier: 28210185

GI number: 28210185

Start: 429283

End: 429606

Strand: Direct

Name: hisE

Synonym: CTC00432

Alternate gene names: 28210185

Gene position: 429283-429606 (Clockwise)

Preceding gene: 28210184

Following gene: 28210187

Centisome position: 15.34

GC content: 24.69

Gene sequence:

>324_bases
ATGGAAGTCAATAAATTAATAGAGGAATTAGTAGAAGTTATAAAAGACAGAAAGAATGACATAATATTCTCTTATTTATT
TGAAGAAGAATCGGATAAAATATTAAAAAAAATAGGCGAGAAAAGCTCAGAGGTTATAATTGCTTGTAAAAATGCATCAA
AAGAAGAGCAAGTACATGAAATATCTGATTTAATATATAATCTAATGGTTCTTATGATGAAACAGAATATAGAAATTGAA
AATGTAATAGAAGAACTAGGAAAAAGAAGAAATATGACTTTAAATAAAAAATCTACAAAATCCGTATATCCAAGTATTCA
CTAA

Upstream 100 bases:

>100_bases
TTGAATTTTATATAAGAGACTAAATAGGATGTAATTTTAAGTAGAATCTTGGAGAATATATAAAAGAGAAAAGAAAAAAT
ATTAAAGGAGAGATATTTTT

Downstream 100 bases:

>100_bases
AAGAATTTAAATAGAGTAACATAAACTTATAGATGACATATATTATTAATATATAAAATACATTAAGAAGAACGTAGATA
AAAGATAAAATGGGAAACTT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 107; Mature: 107

Protein sequence:

>107_residues
MEVNKLIEELVEVIKDRKNDIIFSYLFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEISDLIYNLMVLMMKQNIEIE
NVIEELGKRRNMTLNKKSTKSVYPSIH

Sequences:

>Translated_107_residues
MEVNKLIEELVEVIKDRKNDIIFSYLFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEISDLIYNLMVLMMKQNIEIE
NVIEELGKRRNMTLNKKSTKSVYPSIH
>Mature_107_residues
MEVNKLIEELVEVIKDRKNDIIFSYLFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEISDLIYNLMVLMMKQNIEIE
NVIEELGKRRNMTLNKKSTKSVYPSIH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_CLOTE (Q898L3)

Other databases:

- EMBL:   AE015927
- RefSeq:   NP_781129.1
- ProteinModelPortal:   Q898L3
- SMR:   Q898L3
- GeneID:   1060034
- GenomeReviews:   AE015927_GR
- KEGG:   ctc:CTC00432
- NMPDR:   fig|212717.1.peg.351
- HOGENOM:   HBG646527
- OMA:   IACKNAS
- BioCyc:   CTET212717:CTC_00432-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12529; Mature: 12529

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVNKLIEELVEVIKDRKNDIIFSYLFEEESDKILKKIGEKSSEVIIACKNASKEEQVHE
CCHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
ISDLIYNLMVLMMKQNIEIENVIEELGKRRNMTLNKKSTKSVYPSIH
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVNKLIEELVEVIKDRKNDIIFSYLFEEESDKILKKIGEKSSEVIIACKNASKEEQVHE
CCHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHH
ISDLIYNLMVLMMKQNIEIENVIEELGKRRNMTLNKKSTKSVYPSIH
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129