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The map label for this gene is cpxR [H]

Identifier: 27364655

GI number: 27364655

Start: 1239349

End: 1240032

Strand: Reverse

Name: cpxR [H]

Synonym: VV1_1254

Alternate gene names: 27364655

Gene position: 1240032-1239349 (Counterclockwise)

Preceding gene: 27364659

Following gene: 27364654

Centisome position: 37.78

GC content: 49.12

Gene sequence:

>684_bases
ATGGCAAACATCCTGTTGATTGATGACGATACCGAACTGACGAGCTTGCTGACAGAAGTCTTAAGCTATGAAGGCTTTAA
TGTCACCGAGGCGAACGACGGTGAGCAGGGTTTACAAGCCTTATCGGCAGAGATTGATTTGATCTTACTCGATGTCATGA
TGCCCAAACTCAACGGCATCGATACGTTGAAGAAGTTACGTGAACAGTGGGACACGCCAGTATTAATGCTGACAGCCAAA
GGGGAAGAGATCGATCGTGTCATCGGCTTGGAGCTGGGTGCGGATGACTATCTGCCCAAACCTTTCAGTGATCGTGAACT
GCTGGCACGTATCAAAGCGATTTTGCGCCGCACCAGTGCGACGAAAGCCCCGAAAAGCAGCGATTGCATTGAGTATCAAG
ATCTGAAAATTTATCCGGGCCGATTGGAAGCGTATTGCGCTGGCACTCAACTTGACCTCACTGCGACCGAGTTCGCCTTG
CTGAGCCACTTTATGCAAAACCCAGGGAGCACATTAACCAAAGAGACGCTCAGCTTGGATGTGCTCGGTAAACGCCTAGC
GGCTTTTGACCGTGCCATTGATATGCACGTTTCGAATTTGCGGAAAAAACTCCCTGAACGTGCGGATGGCAAATCTCGAA
TTAAAACCTTACGTGGCCGTGGCTACTTAATGATTGTGGAGTAA

Upstream 100 bases:

>100_bases
ATAGAGAGCGTAAAGTATCGTAAAGAGCGACTTTGCTCCTCTTCCCTGCGGTCATTTCACAGTAATATTAAAGAGAACTG
ATTGAGAGAAAGGCCCTACT

Downstream 100 bases:

>100_bases
CCGATGCGCTTGCCGAAAATCACCAGTTTGTATGGGCGAATTTTTGCGATCTTCTGGTTTACCATGTTTTTGGTGCTGAT
GGCCGTCTTGGCTTTGCCCC

Product: Copper-sensing two-component system response regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MANILLIDDDTELTSLLTEVLSYEGFNVTEANDGEQGLQALSAEIDLILLDVMMPKLNGIDTLKKLREQWDTPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIKAILRRTSATKAPKSSDCIEYQDLKIYPGRLEAYCAGTQLDLTATEFAL
LSHFMQNPGSTLTKETLSLDVLGKRLAAFDRAIDMHVSNLRKKLPERADGKSRIKTLRGRGYLMIVE

Sequences:

>Translated_227_residues
MANILLIDDDTELTSLLTEVLSYEGFNVTEANDGEQGLQALSAEIDLILLDVMMPKLNGIDTLKKLREQWDTPVLMLTAK
GEEIDRVIGLELGADDYLPKPFSDRELLARIKAILRRTSATKAPKSSDCIEYQDLKIYPGRLEAYCAGTQLDLTATEFAL
LSHFMQNPGSTLTKETLSLDVLGKRLAAFDRAIDMHVSNLRKKLPERADGKSRIKTLRGRGYLMIVE
>Mature_226_residues
ANILLIDDDTELTSLLTEVLSYEGFNVTEANDGEQGLQALSAEIDLILLDVMMPKLNGIDTLKKLREQWDTPVLMLTAKG
EEIDRVIGLELGADDYLPKPFSDRELLARIKAILRRTSATKAPKSSDCIEYQDLKIYPGRLEAYCAGTQLDLTATEFALL
SHFMQNPGSTLTKETLSLDVLGKRLAAFDRAIDMHVSNLRKKLPERADGKSRIKTLRGRGYLMIVE

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=61.5720524017467, Blast_Score=258, Evalue=2e-70,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.3259911894273, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=40.3587443946188, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=38.9140271493213, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=31.858407079646, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=37.1681415929204, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.0090497737557, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=36.7713004484305, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=33.1838565022422, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=33.4801762114537, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=29.6137339055794, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=28.6995515695067, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=38.3177570093458, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=36.5853658536585, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=230, Percent_Identity=24.7826086956522, Blast_Score=67, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25345; Mature: 25213

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANILLIDDDTELTSLLTEVLSYEGFNVTEANDGEQGLQALSAEIDLILLDVMMPKLNGI
CCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
DTLKKLREQWDTPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIKAILRRTSA
HHHHHHHHHCCCCEEEEEECCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
TKAPKSSDCIEYQDLKIYPGRLEAYCAGTQLDLTATEFALLSHFMQNPGSTLTKETLSLD
CCCCCCCCCEEECCCEEECCCEEEEECCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHHH
VLGKRLAAFDRAIDMHVSNLRKKLPERADGKSRIKTLRGRGYLMIVE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
ANILLIDDDTELTSLLTEVLSYEGFNVTEANDGEQGLQALSAEIDLILLDVMMPKLNGI
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
DTLKKLREQWDTPVLMLTAKGEEIDRVIGLELGADDYLPKPFSDRELLARIKAILRRTSA
HHHHHHHHHCCCCEEEEEECCCHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
TKAPKSSDCIEYQDLKIYPGRLEAYCAGTQLDLTATEFALLSHFMQNPGSTLTKETLSLD
CCCCCCCCCEEECCCEEECCCEEEEECCCEEECHHHHHHHHHHHHHCCCCHHHHHHHHHH
VLGKRLAAFDRAIDMHVSNLRKKLPERADGKSRIKTLRGRGYLMIVE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]