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The map label for this gene is cpxA [H]

Identifier: 27364654

GI number: 27364654

Start: 1237957

End: 1239345

Strand: Reverse

Name: cpxA [H]

Synonym: VV1_1253

Alternate gene names: 27364654

Gene position: 1239345-1237957 (Counterclockwise)

Preceding gene: 27364655

Following gene: 27364653

Centisome position: 37.76

GC content: 51.12

Gene sequence:

>1389_bases
ATGCGCTTGCCGAAAATCACCAGTTTGTATGGGCGAATTTTTGCGATCTTCTGGTTTACCATGTTTTTGGTGCTGATGGC
CGTCTTGGCTTTGCCCCACCTTGATCCTCGTAAGGCACGCAATATTCCGGCCGATCAATACGATCGCTTTATTGAAGCCA
AGCAGGAGATCGAGAAGCAATATCGTGGCGAAACTGATCTTGGTCGCATTCTCTTTCGCATGGAGCGCCCCGGCGATCGC
CATGGGCGAGATGGCCGGCCGCGCTTTTTCATCACCGATTACGATGGCAATATCCTCACCACCTTGAAGCAAGGGGATTT
TCAACTCAAGGCGCTGAAAAACTTCGTCACCTCGATTGAACAACCCGATCAACCGAAACAAAAACTCTATGGCCGCTTTA
TGCTCTCAGGGCCACTGCCAGTGACGCTAGCGAACAAAGAGTACTTACTTTACGTTGGGATGCGCTGGAACCAACCACCG
CCTTTTTTACTGCGTATGTTTGATCATCCATTTCAGCTACTACTGGCTGTGATGCTGGTCAGTACCCCTTTACTGCTGTG
GCTAGCGTGGGCACTCAGCCAACCCGCACGACGCTTAGAAAAAGCGGCGCAACGTGTCGCTAAAGGGGAATTTGTCACGG
ATCCCTCTTTAGAAAAAGGTACCTCGGAGTTTCGCCAAGCCGGCGCCAGCTTCAACCGCATGGTCGAAGCGGTCAATCAG
ATGATTTCAGGTCAGCAACGGTTGCTGTCGGATATTTCCCATGAACTGCGCTCGCCACTAACCCGCTTGAGAATGGCCAA
TGCGCTTGCGACACGCAAACAGGGCGAAAGTAATGAGCTGCAACGAATTGATACCGAAGCGCAACGTTTGGAACAGATGA
TCAGTGAACTGCTGGAGCTGTCTCGCATGCAGATGAACAGCCATTTGGATCGTGAAGAGCAGCCCGTCGCCAGCCTATGG
GAAGAGATCATTCAAGATGCACAATTTGAAGCGGAACAAATGGGCAAAGTATTGCAATACACCCCGTTACCCGAGCGACA
TATTTCCGGTAATCCTAAGCTGTTGATGAGCGCGATCGAAAACATCATTCGCAATGCCATCTACTACGGCAAAGACCAAG
TGATCATCGCTATTCAAGCCATCGACGACACACTACATATCGTGGTGGATGATAATGGTGAAGGGGTACCTGAAGAGGAA
CTCGAAGCCATTTTCCGTCCGTTTTATCGAGTCTCTACCGCTCGGGATCGTCATTCTGGAGGAACCGGGCTCGGCTTAAG
CATCACCGAAAGCGCGATTCGTCAGCACAGCGGCACCATAAACGCTGAGCGCAGCGATCTTGGCGGTTTGCGAGTCACCA
TTACTCTTCCACTGGTGAAAAGGCGTTAA

Upstream 100 bases:

>100_bases
CGTTTCGAATTTGCGGAAAAAACTCCCTGAACGTGCGGATGGCAAATCTCGAATTAAAACCTTACGTGGCCGTGGCTACT
TAATGATTGTGGAGTAACCG

Downstream 100 bases:

>100_bases
TACCCTTACAAAGATCGCAGTTGATAATGGTTATCATTAAGATTATGGTAAATCCTTCATCACCGGAGGATTTACCATGT
CACACACTTTCCCTGAGCTT

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQYRGETDLGRILFRMERPGDR
HGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIEQPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPP
PFLLRMFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLELSRMQMNSHLDREEQPVASLW
EEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIENIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEE
LEAIFRPFYRVSTARDRHSGGTGLGLSITESAIRQHSGTINAERSDLGGLRVTITLPLVKRR

Sequences:

>Translated_462_residues
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQYRGETDLGRILFRMERPGDR
HGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIEQPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPP
PFLLRMFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLELSRMQMNSHLDREEQPVASLW
EEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIENIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEE
LEAIFRPFYRVSTARDRHSGGTGLGLSITESAIRQHSGTINAERSDLGGLRVTITLPLVKRR
>Mature_462_residues
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQYRGETDLGRILFRMERPGDR
HGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIEQPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPP
PFLLRMFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLELSRMQMNSHLDREEQPVASLW
EEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIENIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEE
LEAIFRPFYRVSTARDRHSGGTGLGLSITESAIRQHSGTINAERSDLGGLRVTITLPLVKRR

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=460, Percent_Identity=45.8695652173913, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1787894, Length=324, Percent_Identity=31.1728395061728, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786783, Length=344, Percent_Identity=25.5813953488372, Blast_Score=116, Evalue=4e-27,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=28.2828282828283, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI87082128, Length=275, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=29.3103448275862, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=28.0575539568345, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787374, Length=285, Percent_Identity=27.3684210526316, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=30.4545454545455, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=27.5423728813559, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=294, Percent_Identity=25.8503401360544, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1789403, Length=331, Percent_Identity=26.8882175226586, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI48994928, Length=247, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=213, Percent_Identity=26.2910798122066, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=27.9279279279279, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790551, Length=277, Percent_Identity=26.7148014440433, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52910; Mature: 52910

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
YRGETDLGRILFRMERPGDRHGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIE
HCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCC
QPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPPPFLLRMFDHPFQLLLAVMLV
CCCCHHHHHHHHHEECCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHH
STPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRMQMNSHLDREEQPVASLWEEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIE
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHCHHHHCCCCCHHHCCCCHHHHHHHHH
NIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEELEAIFRPFYRVSTARDRHSG
HHHHHHHHCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GTGLGLSITESAIRQHSGTINAERSDLGGLRVTITLPLVKRR
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MRLPKITSLYGRIFAIFWFTMFLVLMAVLALPHLDPRKARNIPADQYDRFIEAKQEIEKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
YRGETDLGRILFRMERPGDRHGRDGRPRFFITDYDGNILTTLKQGDFQLKALKNFVTSIE
HCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCC
QPDQPKQKLYGRFMLSGPLPVTLANKEYLLYVGMRWNQPPPFLLRMFDHPFQLLLAVMLV
CCCCHHHHHHHHHEECCCCCEEECCCCEEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHH
STPLLLWLAWALSQPARRLEKAAQRVAKGEFVTDPSLEKGTSEFRQAGASFNRMVEAVNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHH
MISGQQRLLSDISHELRSPLTRLRMANALATRKQGESNELQRIDTEAQRLEQMISELLEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRMQMNSHLDREEQPVASLWEEIIQDAQFEAEQMGKVLQYTPLPERHISGNPKLLMSAIE
HHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHCHHHHCCCCCHHHCCCCHHHHHHHHH
NIIRNAIYYGKDQVIIAIQAIDDTLHIVVDDNGEGVPEEELEAIFRPFYRVSTARDRHSG
HHHHHHHHCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
GTGLGLSITESAIRQHSGTINAERSDLGGLRVTITLPLVKRR
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]