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The map label for this gene is phoP

Identifier: 255767672

GI number: 255767672

Start: 2977800

End: 2978522

Strand: Reverse

Name: phoP

Synonym: BSU29110

Alternate gene names: 255767672

Gene position: 2978522-2977800 (Counterclockwise)

Preceding gene: 16079964

Following gene: 16079962

Centisome position: 70.65

GC content: 42.19

Gene sequence:

>723_bases
ATGAACAAGAAAATTTTAGTTGTGGATGATGAAGAATCTATTGTTACTCTTTTACAGTACAATTTGGAACGGTCAGGCTA
TGATGTCATTACCGCCTCGGATGGGGAAGAAGCACTCAAAAAAGCGGAAACAGAGAAACCTGATTTGATTGTGCTTGATG
TGATGCTTCCAAAATTGGACGGAATCGAAGTATGCAAGCAGCTGAGACAGCAAAAACTGATGTTTCCCATTTTAATGCTG
ACAGCGAAGGATGAGGAATTCGACAAAGTATTAGGGCTGGAGCTCGGTGCTGATGATTATATGACCAAGCCGTTCAGTCC
AAGGGAAGTAAATGCGAGAGTCAAAGCGATTTTAAGGCGTTCGGAAATAGCTGCGCCCTCTAGTGAGATGAAGAACGATG
AAATGGAAGGCCAGATCGTAATCGGCGATCTGAAAATCCTGCCTGATCATTATGAAGCGTACTTTAAAGAAAGTCAGCTT
GAACTGACACCGAAAGAATTCGAACTGCTGCTCTATTTAGGCAGACATAAAGGCAGAGTTCTGACAAGAGACCTGCTGCT
GAGCGCAGTCTGGAATTATGATTTTGCCGGAGATACGAGAATTGTTGATGTGCACATCAGCCATCTTCGCGACAAAATTG
AAAACAATACCAAAAAACCGATCTACATTAAAACGATTAGGGGATTGGGGTATAAACTGGAGGAGCCAAAAATGAATGAA
TAA

Upstream 100 bases:

>100_bases
GGAATGTCCTGCTTTCGCTAAAATAAAATCATGAAACATGTTAAGATGACATAAAATAGAGAAATAGGATGTCGGGGAAT
TATAATACTGGAGGCACAGC

Downstream 100 bases:

>100_bases
ATACCGTGTGCGCCTTTTTTCTGTATTCGTTGTCTGTATGATTCTGGTGTTTTGTGTCCTCGGGCTGTTTTTACAGCAGC
TTTTTGAAACATCTGATCAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAETEKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILML
TAKDEEFDKVLGLELGADDYMTKPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL
ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTKKPIYIKTIRGLGYKLEEPKMNE

Sequences:

>Translated_240_residues
MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAETEKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILML
TAKDEEFDKVLGLELGADDYMTKPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL
ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTKKPIYIKTIRGLGYKLEEPKMNE
>Mature_240_residues
MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAETEKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILML
TAKDEEFDKVLGLELGADDYMTKPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL
ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTKKPIYIKTIRGLGYKLEEPKMNE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=39.9141630901288, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786599, Length=235, Percent_Identity=39.5744680851064, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=39.3162393162393, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=43.6681222707424, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1786784, Length=233, Percent_Identity=39.0557939914163, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=39.5744680851064, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786911, Length=231, Percent_Identity=37.6623376623377, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=34.3478260869565, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI87082012, Length=234, Percent_Identity=34.1880341880342, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=33.6206896551724, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=34.3347639484979, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1790863, Length=240, Percent_Identity=32.5, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787375, Length=232, Percent_Identity=30.1724137931034, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=237, Percent_Identity=29.957805907173, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=32.4786324786325, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=150, Percent_Identity=30.6666666666667, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790437, Length=104, Percent_Identity=37.5, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788713, Length=167, Percent_Identity=28.1437125748503, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=29.8076923076923, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=35.2941176470588, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHOP_BACSU (P13792)

Other databases:

- EMBL:   X67676
- EMBL:   M16775
- EMBL:   AF008220
- EMBL:   AL009126
- EMBL:   U05257
- EMBL:   M23549
- PIR:   F69676
- RefSeq:   NP_390789.2
- PDB:   1MVO
- PDBsum:   1MVO
- ProteinModelPortal:   P13792
- SMR:   P13792
- EnsemblBacteria:   EBBACT00000003911
- GeneID:   936644
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU29110
- NMPDR:   fig|224308.1.peg.2914
- GenoList:   BSU29110
- GeneTree:   EBGT00070000031753
- HOGENOM:   HBG753323
- PhylomeDB:   P13792
- ProtClustDB:   CLSK2393393
- BioCyc:   BSUB:BSU29110-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF46894 Bipartite_resp_reg_C-effector; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 27598; Mature: 27598

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAETEKPDLIVLDVMLPKLD
CCCCEEEEECCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEECCCCC
GIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMTKPFSPREVNARVKAILRR
HHHHHHHHHHHHHHHHEEEEEECCHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHHH
SEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQLELTPKEFELLLYLGRHKGRV
HHCCCCHHHHCCCCCCCEEEEEEEEECCHHHHHHHCCCCEEECHHHHEEEEEECCCCCCC
LTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTKKPIYIKTIRGLGYKLEEPKMNE
HHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAETEKPDLIVLDVMLPKLD
CCCCEEEEECCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEEECCCCC
GIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMTKPFSPREVNARVKAILRR
HHHHHHHHHHHHHHHHEEEEEECCHHHHHHHCEEECCCCCCCCCCCCHHHHHHHHHHHHH
SEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQLELTPKEFELLLYLGRHKGRV
HHCCCCHHHHCCCCCCCEEEEEEEEECCHHHHHHHCCCCEEECHHHHEEEEEECCCCCCC
LTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTKKPIYIKTIRGLGYKLEEPKMNE
HHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862