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The map label for this gene is phoR

Identifier: 16079962

GI number: 16079962

Start: 2976068

End: 2977807

Strand: Reverse

Name: phoR

Synonym: BSU29100

Alternate gene names: 16079962

Gene position: 2977807-2976068 (Counterclockwise)

Preceding gene: 255767672

Following gene: 16079961

Centisome position: 70.64

GC content: 45.29

Gene sequence:

>1740_bases
ATGAATAAATACCGTGTGCGCCTTTTTTCTGTATTCGTTGTCTGTATGATTCTGGTGTTTTGTGTCCTCGGGCTGTTTTT
ACAGCAGCTTTTTGAAACATCTGATCAAAGGAAAGCAGAGGAACACATTGAAAAAGAAGCAAAATACTTGGCTTCGCTTC
TTGATGCCGGCAATCTGAATAATCAAGCAAATGAGAAAATCATTAAAGATGCAGGCGGCGCGCTTGATGTGAGCGCATCC
GTTATCGATACAGACGGTAAGGTGCTGTATGGGTCAAACGGTAGATCGGCTGATTCCCAAAAGGTGCAGGCGCTTGTTTC
TGGCCATGAGGGTATTCTGTCAACAACAGATAACAAGCTTTATTACGGACTTTCACTTAGAAGCGAAGGTGAAAAAACAG
GATATGTGCTGCTTTCCGCCTCTGAAAAAAGCGACGGCTTAAAAGGCGAATTGTGGGGGATGCTGACGGCCAGTCTTTGT
ACCGCATTTATCGTCATTGTTTATTTTTATTCCAGCATGACCTCACGTTATAAAAGGTCAATTGAGTCAGCGACAAATGT
AGCCACAGAACTCTCTAAGGGCAACTACGATGCACGGACGTACGGCGGCTATATTAGGCGTTCTGATAAGCTAGGACATG
CGATGAACAGCCTTGCCATTGATCTGATGGAAATGACGCGAACGCAGGAAATGCAGCGGGATCGGCTGCTGACAGTCATT
GAAAACATTGGCTCCGGGCTGATTATGATCGACGGAAGAGGCTTTATTAATCTCGTAAACAGGTCTTACGCCAAGCAGTT
TCATATCAATCCGAATCATATGCTGCGCCGTCTTTATCACGATGCATTTGAACATGAAGAAGTGATCCAGCTTGTCGAAG
ACATTTTTATGACGGAGACAAAGAAATGCAAGCTGTTAAGACTGCCGATCAAAATAGAACGGCGTTATTTTGAAGTGGAC
GGCGTTCCGATTATGGGGCCGGACGATGAATGGAAAGGAATTGTGCTCGTTTTCCATGACATGACGGAAACGAAGAAATT
AGAGCAGATGAGGAAGGATTTTGTGGCCAATGTTTCTCATGAGCTGAAAACACCGATTACGTCCATAAAAGGGTTTACGG
AGACGTTATTGGACGGGGCGATGGAAGACAAAGAGGCGCTTTCTGAATTTCTCTCTATTATTCTTAAGGAAAGCGAAAGG
CTTCAGTCTTTGGTTCAGGATTTGCTCGATCTCTCAAAAATCGAGCAGCAAAATTTCACGCTCAGTATCGAAACGTTTGA
GCCGGCCAAAATGCTTGGTGAGATTGAAACGCTTCTGAAGCATAAGGCGGATGAGAAAGGCATCTCCTTGCACCTGAATG
TCCCGAAAGACCCTCAATATGTATCTGGTGACCCGTACAGGCTGAAACAGGTATTTCTTAATCTCGTAAACAATGCATTA
ACCTACACGCCTGAGGGGGGCTCCGTGGCTATCAATGTAAAGCCCAGAGAAAAAGACATTCAGATTGAGGTTGCCGATTC
TGGAATCGGAATTCAGAAAGAAGAAATTCCGCGCATCTTTGAACGCTTTTACCGTGTAGATAAAGACAGAAGCAGAAATT
CGGGCGGAACCGGGCTGGGCCTAGCGATTGTCAAGCATTTAATAGAGGCTCATGAAGGGAAAATTGATGTCACAAGCGAG
CTTGGACGGGGAACTGTCTTTACCGTGACGCTGAAACGGGCCGCTGAAAAGTCCGCCTAA

Upstream 100 bases:

>100_bases
ATCAGCCATCTTCGCGACAAAATTGAAAACAATACCAAAAAACCGATCTACATTAAAACGATTAGGGGATTGGGGTATAA
ACTGGAGGAGCCAAAAATGA

Downstream 100 bases:

>100_bases
TGTTTACAAAGGTTTAACAATATCTTCATGCACTGTTAAACCTATGCTGGTAGGATGTAGTAGAACCCCTTCATCCAAGG
AGCCAATTTTGACGGCGGGA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSAS
VIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC
TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVI
ENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVD
GVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESER
LQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNAL
TYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSE
LGRGTVFTVTLKRAAEKSA

Sequences:

>Translated_579_residues
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSAS
VIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC
TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVI
ENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVD
GVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESER
LQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNAL
TYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSE
LGRGTVFTVTLKRAAEKSA
>Mature_579_residues
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSAS
VIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC
TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVI
ENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVD
GVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESER
LQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNAL
TYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSE
LGRGTVFTVTLKRAAEKSA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

Homologues:

Organism=Escherichia coli, GI1786600, Length=262, Percent_Identity=36.2595419847328, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=34.6456692913386, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789149, Length=225, Percent_Identity=36.4444444444444, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=34.2857142857143, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI48994928, Length=266, Percent_Identity=33.0827067669173, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI145693157, Length=229, Percent_Identity=33.6244541484716, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=36.3636363636364, Blast_Score=121, Evalue=2e-28,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=33.6206896551724, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=32.6771653543307, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=30.2752293577982, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1790861, Length=239, Percent_Identity=28.4518828451883, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788549, Length=463, Percent_Identity=22.8941684665227, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=30.1310043668122, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=28.755364806867, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790300, Length=233, Percent_Identity=31.3304721030043, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=225, Percent_Identity=28, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=29.5154185022026, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=203, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790551, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHOR_BACSU (P23545)

Other databases:

- EMBL:   M23549
- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   A27650
- RefSeq:   NP_390788.1
- PDB:   3CWF
- PDBsum:   3CWF
- ProteinModelPortal:   P23545
- IntAct:   P23545
- EnsemblBacteria:   EBBACT00000003232
- GeneID:   937387
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU29100
- NMPDR:   fig|224308.1.peg.2913
- GenoList:   BSU29100
- GeneTree:   EBGT00070000031815
- HOGENOM:   HBG334875
- OMA:   GFKLNMG
- PhylomeDB:   P23545
- ProtClustDB:   CLSK873523
- BioCyc:   BSUB:BSU29100-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00387
- SMART:   SM00388
- SMART:   SM00091
- TIGRFAMs:   TIGR00229

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 65123; Mature: 65123

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50109 HIS_KIN; PS50112 PAS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x103106f0)-; HASH(0x115ccb38)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
NQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKL
CHHHHHHHHHCCCCEEEEEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCEECCCCCE
YYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLCTAFIVIVYFYSSMTSRYKRS
EEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVI
HHHHHHHHHHHHCCCCCCHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTET
HHHCCCEEEECCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCC
KKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSH
CCCEEEECCCEEECEEEEECCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
ELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESERLQSLVQDLLDLSKIEQQNFT
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNAL
EEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCE
TYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLG
EECCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LAIVKHLIEAHEGKIDVTSELGRGTVFTVTLKRAAEKSA
HHHHHHHHHHCCCCEEEHHHCCCCEEEEEEEHHHHCCCH
>Mature Secondary Structure
MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIEKEAKYLASLLDAGNLN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
NQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKVQALVSGHEGILSTTDNKL
CHHHHHHHHHCCCCEEEEEEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCEECCCCCE
YYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLCTAFIVIVYFYSSMTSRYKRS
EEEEEECCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSLAIDLMEMTRTQEMQRDRLLTVI
HHHHHHHHHHHHCCCCCCHHHCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLRRLYHDAFEHEEVIQLVEDIFMTET
HHHCCCEEEECCCCHHHHHHHHHHHEECCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCC
KKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGIVLVFHDMTETKKLEQMRKDFVANVSH
CCCEEEECCCEEECEEEEECCEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
ELKTPITSIKGFTETLLDGAMEDKEALSEFLSIILKESERLQSLVQDLLDLSKIEQQNFT
HHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LSIETFEPAKMLGEIETLLKHKADEKGISLHLNVPKDPQYVSGDPYRLKQVFLNLVNNAL
EEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCE
TYTPEGGSVAINVKPREKDIQIEVADSGIGIQKEEIPRIFERFYRVDKDRSRNSGGTGLG
EECCCCCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHH
LAIVKHLIEAHEGKIDVTSELGRGTVFTVTLKRAAEKSA
HHHHHHHHHHCCCCEEEHHHCCCCEEEEEEEHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377