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The map label for this gene is tdh [H]

Identifier: 239618484

GI number: 239618484

Start: 2257586

End: 2258641

Strand: Direct

Name: tdh [H]

Synonym: Kole_2125

Alternate gene names: 239618484

Gene position: 2257586-2258641 (Clockwise)

Preceding gene: 239618483

Following gene: 239618485

Centisome position: 98.07

GC content: 43.94

Gene sequence:

>1056_bases
TTGAAAAAAACAATGAAAGCTATTGTCAAAGAAACATGTGGTCCCGGTTTTTCATTGAAAGAGGTTCCTGTTCCAGAGGA
ACTAGGGCCAAATGAGGTTCTTGTAAAAGTGGATAAAGCATCGATCTGCGGAACGGATGTTCACATCTATGAATGGAACG
AGTGGTCTCAGCAAAGAATAAAACCGCCGCAAATAGCAGGGCATGAATTCACAGGAGAGGTTATAGAGGTTGGCGAAAAT
GTTTCCATGGTATCTGTTGGAGACAGAGTTGTTTCCGAAACGCACATCCCTTGTATGAAATGCTTACAGTGCAAAACCGG
GAAAATGCACATCTGCAGAGACATGGAAATTCTCGGAGTTGACAGGGATGGTGTCTTTGCCAAATACGTAAAGGTACCTG
AAATTGTTCTCTGGAAAGTGGATAAAGGGATTCCCGCAGAGTACGCTTCGATAATGGAACCCTTTGGAAATGCTGTACAC
ACAGCTCTTGTAACAGATCTGACCGGTAAAAACGTTTTAATTACGGGTGCCGGGCCAATCGGCGTAATGGCTGCCGCCGT
TGCGAAAGCCTCAGGAGCAGCCCGGGTCATAGTTACCGAACTAAAAGACTTCCGCAAATCACTTGCGAAAAAAATGGGAG
CAGATGTCGTGCTCGATCCCAGGGAAATAGATGTTCCTTCAAAAGTAAAAGAACTAACTGAAGGTAACGGTGTGGATGTA
CTTCTCGAAATGTCCGGAAATGTCAACGCTCTTGTTCAGGGGCTTCAAAGCATAACCAACGGTGGAGTAGTTTCGCTCCT
TGGAGTGTTCCCTGGCAGTATCAGCTTCGATATCAATTCCCTGATTATCTTCAAAGGCCTCACAGTTTTTGGAATCACTG
GTCGTAAGATGTTTGAAACCTGGCAAATAGCAACCCAATTATTAAAAAACAACGTTGTGGATCTATCTCCTATTGTCACT
CACATTGTAAAGATGGAAGACTGGGAAAAAGGCTTTGAAGCTATGATGAGTGGTAGTTCTGGTAAGGTAATAATAGATAT
TTCCGAGGGGGTGTAA

Upstream 100 bases:

>100_bases
TCGCTCAAATAAGCAATTAGGGTGCTCTATTTGTTTTTTGAAAAGAATATTTCATAAGATAAACTAAAAATGAGAGATTA
TGAATAAGGAGGCTGGGGGC

Downstream 100 bases:

>100_bases
GGATGTTCGATTATAACGAATTCTCAAAAGAGCTAAAAGAGCTCGAAGAAAAAGGTCTTCTCGTTAGAATTAGAACATTA
CAAAGTCCTCAGGGAGCCTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKKTMKAIVKETCGPGFSLKEVPVPEELGPNEVLVKVDKASICGTDVHIYEWNEWSQQRIKPPQIAGHEFTGEVIEVGEN
VSMVSVGDRVVSETHIPCMKCLQCKTGKMHICRDMEILGVDRDGVFAKYVKVPEIVLWKVDKGIPAEYASIMEPFGNAVH
TALVTDLTGKNVLITGAGPIGVMAAAVAKASGAARVIVTELKDFRKSLAKKMGADVVLDPREIDVPSKVKELTEGNGVDV
LLEMSGNVNALVQGLQSITNGGVVSLLGVFPGSISFDINSLIIFKGLTVFGITGRKMFETWQIATQLLKNNVVDLSPIVT
HIVKMEDWEKGFEAMMSGSSGKVIIDISEGV

Sequences:

>Translated_351_residues
MKKTMKAIVKETCGPGFSLKEVPVPEELGPNEVLVKVDKASICGTDVHIYEWNEWSQQRIKPPQIAGHEFTGEVIEVGEN
VSMVSVGDRVVSETHIPCMKCLQCKTGKMHICRDMEILGVDRDGVFAKYVKVPEIVLWKVDKGIPAEYASIMEPFGNAVH
TALVTDLTGKNVLITGAGPIGVMAAAVAKASGAARVIVTELKDFRKSLAKKMGADVVLDPREIDVPSKVKELTEGNGVDV
LLEMSGNVNALVQGLQSITNGGVVSLLGVFPGSISFDINSLIIFKGLTVFGITGRKMFETWQIATQLLKNNVVDLSPIVT
HIVKMEDWEKGFEAMMSGSSGKVIIDISEGV
>Mature_351_residues
MKKTMKAIVKETCGPGFSLKEVPVPEELGPNEVLVKVDKASICGTDVHIYEWNEWSQQRIKPPQIAGHEFTGEVIEVGEN
VSMVSVGDRVVSETHIPCMKCLQCKTGKMHICRDMEILGVDRDGVFAKYVKVPEIVLWKVDKGIPAEYASIMEPFGNAVH
TALVTDLTGKNVLITGAGPIGVMAAAVAKASGAARVIVTELKDFRKSLAKKMGADVVLDPREIDVPSKVKELTEGNGVDV
LLEMSGNVNALVQGLQSITNGGVVSLLGVFPGSISFDINSLIIFKGLTVFGITGRKMFETWQIATQLLKNNVVDLSPIVT
HIVKMEDWEKGFEAMMSGSSGKVIIDISEGV

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=338, Percent_Identity=30.7692307692308, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=28.9617486338798, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=26.5582655826558, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=28.4153005464481, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=26.7955801104972, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=28.4153005464481, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=27.4725274725275, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=27.4725274725275, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI71565152, Length=362, Percent_Identity=26.5193370165746, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71565154, Length=380, Percent_Identity=26.0526315789474, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=46.3343108504399, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1788073, Length=320, Percent_Identity=30.625, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788075, Length=349, Percent_Identity=29.7994269340974, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI226510992, Length=258, Percent_Identity=30.6201550387597, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI87082125, Length=352, Percent_Identity=29.8295454545455, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787863, Length=309, Percent_Identity=29.7734627831715, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788407, Length=357, Percent_Identity=26.6106442577031, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1790718, Length=313, Percent_Identity=28.4345047923323, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786825, Length=381, Percent_Identity=25.4593175853018, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=378, Percent_Identity=27.2486772486773, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081918, Length=329, Percent_Identity=27.9635258358663, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=30.8383233532934, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562878, Length=205, Percent_Identity=34.1463414634146, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=354, Percent_Identity=24.8587570621469, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562584, Length=353, Percent_Identity=28.0453257790368, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=353, Percent_Identity=26.3456090651558, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=350, Percent_Identity=25.4285714285714, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=352, Percent_Identity=25.2840909090909, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=336, Percent_Identity=25.8928571428571, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=29.8507462686567, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319955, Length=340, Percent_Identity=29.4117647058824, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=29.7619047619048, Blast_Score=145, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319257, Length=277, Percent_Identity=29.9638989169675, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=379, Percent_Identity=26.3852242744063, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=273, Percent_Identity=31.1355311355311, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=357, Percent_Identity=27.7310924369748, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=23.5457063711911, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=276, Percent_Identity=26.8115942028986, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=275, Percent_Identity=29.4545454545455, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=203, Percent_Identity=31.5270935960591, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=202, Percent_Identity=29.2079207920792, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137530, Length=340, Percent_Identity=29.4117647058824, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17737897, Length=204, Percent_Identity=34.3137254901961, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI17737895, Length=356, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221457811, Length=340, Percent_Identity=24.4117647058824, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45551930, Length=340, Percent_Identity=24.4117647058824, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550770, Length=340, Percent_Identity=24.4117647058824, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 37894; Mature: 37894

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTMKAIVKETCGPGFSLKEVPVPEELGPNEVLVKVDKASICGTDVHIYEWNEWSQQRI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHCC
KPPQIAGHEFTGEVIEVGENVSMVSVGDRVVSETHIPCMKCLQCKTGKMHICRDMEILGV
CCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHCCCHHHHHHHCCCCCEEEECCCEEEEC
DRDGVFAKYVKVPEIVLWKVDKGIPAEYASIMEPFGNAVHTALVTDLTGKNVLITGAGPI
CCCCCEEHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
GVMAAAVAKASGAARVIVTELKDFRKSLAKKMGADVVLDPREIDVPSKVKELTEGNGVDV
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCEEECCHHCCCCHHHHHHHCCCCEEE
LLEMSGNVNALVQGLQSITNGGVVSLLGVFPGSISFDINSLIIFKGLTVFGITGRKMFET
EEECCCCHHHHHHHHHHHCCCCCEEEHHHCCCCEEECCCEEEEEECCEEEEECCHHHHHH
WQIATQLLKNNVVDLSPIVTHIVKMEDWEKGFEAMMSGSSGKVIIDISEGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MKKTMKAIVKETCGPGFSLKEVPVPEELGPNEVLVKVDKASICGTDVHIYEWNEWSQQRI
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCHHHHCC
KPPQIAGHEFTGEVIEVGENVSMVSVGDRVVSETHIPCMKCLQCKTGKMHICRDMEILGV
CCCCCCCCCCCCHHHHCCCCCEEEECCCHHHHHCCCHHHHHHHCCCCCEEEECCCEEEEC
DRDGVFAKYVKVPEIVLWKVDKGIPAEYASIMEPFGNAVHTALVTDLTGKNVLITGAGPI
CCCCCEEHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
GVMAAAVAKASGAARVIVTELKDFRKSLAKKMGADVVLDPREIDVPSKVKELTEGNGVDV
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCEEECCHHCCCCHHHHHHHCCCCEEE
LLEMSGNVNALVQGLQSITNGGVVSLLGVFPGSISFDINSLIIFKGLTVFGITGRKMFET
EEECCCCHHHHHHHHHHHCCCCCEEEHHHCCCCEEECCCEEEEEECCEEEEECCHHHHHH
WQIATQLLKNNVVDLSPIVTHIVKMEDWEKGFEAMMSGSSGKVIIDISEGV
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]