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The map label for this gene is kbl [C]

Identifier: 239618485

GI number: 239618485

Start: 2258644

End: 2259825

Strand: Direct

Name: kbl [C]

Synonym: Kole_2126

Alternate gene names: 239618485

Gene position: 2258644-2259825 (Clockwise)

Preceding gene: 239618484

Following gene: 239618486

Centisome position: 98.11

GC content: 42.98

Gene sequence:

>1182_bases
ATGTTCGATTATAACGAATTCTCAAAAGAGCTAAAAGAGCTCGAAGAAAAAGGTCTTCTCGTTAGAATTAGAACATTACA
AAGTCCTCAGGGAGCCTGGTTAACGATCGACGGGAAAAAGGTTTTGAATCTTTGTTCCAACAACTATCTGGGTTTAGCGT
TCAATGAAGAGCTTAAAAAGGCTGCCATTGAAGCAATAGAAAAATGGGGTGTCGGTCCTGGAGCAGTTAGAACGATAGCT
GGAACACTCGAAATTCACGAGCTTCTTGAAAAGGAACTTGCTGAATTCAAGAAAGTAGAAGCAACCCTTGTACTTCAGTC
AGGTTTCAACGCGAATCAAGCAGTTATTCCGGCAATAACCACAGCTGAAGATGCTATTCTCTCAGATGAACTGAACCATG
CGAGTATAATCGACGGAGTCAGGCTTTCCAAAGCGAAACGCTACGTCTGGAAACACAGAGACGCTGAAGACCTTGAAGAG
AAACTGAAGCAAGCCAAAGCTGAAGGTTCAAGAAGACTATTGGTAATCACTGATGGAGTCTTCTCAATGGATGGAGACCT
CGCCCCGCTTCCCGAGATCGTCGAAAAATGTGAAAAATATGATGCTCTGCTCATGGTAGATGACGCTCACGGAGAAGGGG
TACTCGGAAGTCATGGTCGTGGAATCGTCGATCATTTTGATCTTCATGGAAGAGTCGATATTGAAGTTGGAACCCTTTCC
AAAGCCTTCGGAGTAGTTGGCGGATTTGTTGCCGGTAAAAAAGATCTCATAGATTATCTAAAACAAAAAGCACGTCCTTT
CCTGTTCAGTAGTTCGCTATCACCAGCAGAAACTGGTGCCGCTCTTGCTGCCGTGAGAATGCTCAAAGCTTCCGATGAAC
TGGTTAAAAAGCTCTGGGATAATGCCAGTTATTTCAAAACGGAAATGCAGAAACTGGGATTCGATACAGGTCACAGTGAA
ACCCCAATAACTCCTGTCATGCTTTACGACGCCAAATTGTCATCTCAGTTCAGTAAAAAACTATTTGAAGAAGGAATATT
CGCCCAATCTATCGGTTATCCAACCGTTCCAAAGGGTAAGGCAAGAATAAGAGTTATGATAAGTGCCGTCCACACGAAAG
AAGATCTCGATTTTGCCCTTGGAAAATTCAAAAAAGTCGGTAAAGAACTTGGTGTGATATAA

Upstream 100 bases:

>100_bases
CTCACATTGTAAAGATGGAAGACTGGGAAAAAGGCTTTGAAGCTATGATGAGTGGTAGTTCTGGTAAGGTAATAATAGAT
ATTTCCGAGGGGGTGTAAGG

Downstream 100 bases:

>100_bases
TAATTACCAGTCGATACCATGGCGATGGTGGGATTTCCACCATCGCTTTTTATGGAGGCGAGCGTATTGCTAAACCTCTT
GTTACTCGCGATTGGTATTT

Product: pyridoxal phosphate-dependent acyltransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MFDYNEFSKELKELEEKGLLVRIRTLQSPQGAWLTIDGKKVLNLCSNNYLGLAFNEELKKAAIEAIEKWGVGPGAVRTIA
GTLEIHELLEKELAEFKKVEATLVLQSGFNANQAVIPAITTAEDAILSDELNHASIIDGVRLSKAKRYVWKHRDAEDLEE
KLKQAKAEGSRRLLVITDGVFSMDGDLAPLPEIVEKCEKYDALLMVDDAHGEGVLGSHGRGIVDHFDLHGRVDIEVGTLS
KAFGVVGGFVAGKKDLIDYLKQKARPFLFSSSLSPAETGAALAAVRMLKASDELVKKLWDNASYFKTEMQKLGFDTGHSE
TPITPVMLYDAKLSSQFSKKLFEEGIFAQSIGYPTVPKGKARIRVMISAVHTKEDLDFALGKFKKVGKELGVI

Sequences:

>Translated_393_residues
MFDYNEFSKELKELEEKGLLVRIRTLQSPQGAWLTIDGKKVLNLCSNNYLGLAFNEELKKAAIEAIEKWGVGPGAVRTIA
GTLEIHELLEKELAEFKKVEATLVLQSGFNANQAVIPAITTAEDAILSDELNHASIIDGVRLSKAKRYVWKHRDAEDLEE
KLKQAKAEGSRRLLVITDGVFSMDGDLAPLPEIVEKCEKYDALLMVDDAHGEGVLGSHGRGIVDHFDLHGRVDIEVGTLS
KAFGVVGGFVAGKKDLIDYLKQKARPFLFSSSLSPAETGAALAAVRMLKASDELVKKLWDNASYFKTEMQKLGFDTGHSE
TPITPVMLYDAKLSSQFSKKLFEEGIFAQSIGYPTVPKGKARIRVMISAVHTKEDLDFALGKFKKVGKELGVI
>Mature_393_residues
MFDYNEFSKELKELEEKGLLVRIRTLQSPQGAWLTIDGKKVLNLCSNNYLGLAFNEELKKAAIEAIEKWGVGPGAVRTIA
GTLEIHELLEKELAEFKKVEATLVLQSGFNANQAVIPAITTAEDAILSDELNHASIIDGVRLSKAKRYVWKHRDAEDLEE
KLKQAKAEGSRRLLVITDGVFSMDGDLAPLPEIVEKCEKYDALLMVDDAHGEGVLGSHGRGIVDHFDLHGRVDIEVGTLS
KAFGVVGGFVAGKKDLIDYLKQKARPFLFSSSLSPAETGAALAAVRMLKASDELVKKLWDNASYFKTEMQKLGFDTGHSE
TPITPVMLYDAKLSSQFSKKLFEEGIFAQSIGYPTVPKGKARIRVMISAVHTKEDLDFALGKFKKVGKELGVI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=387, Percent_Identity=43.4108527131783, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI284448556, Length=354, Percent_Identity=44.9152542372881, Blast_Score=312, Evalue=3e-85,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=37.2602739726027, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=35.2459016393443, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI83977442, Length=348, Percent_Identity=33.6206896551724, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI83977440, Length=348, Percent_Identity=33.6206896551724, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI83977444, Length=348, Percent_Identity=33.6206896551724, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4502025, Length=364, Percent_Identity=33.5164835164835, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI40316939, Length=364, Percent_Identity=33.5164835164835, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI5454084, Length=385, Percent_Identity=28.3116883116883, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1790046, Length=392, Percent_Identity=44.8979591836735, Blast_Score=352, Evalue=2e-98,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=36.676217765043, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71994529, Length=390, Percent_Identity=44.8717948717949, Blast_Score=325, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI32566772, Length=393, Percent_Identity=32.824427480916, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17560914, Length=354, Percent_Identity=31.0734463276836, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17560912, Length=354, Percent_Identity=31.0734463276836, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71982617, Length=278, Percent_Identity=30.9352517985612, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71982625, Length=278, Percent_Identity=30.9352517985612, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320438, Length=379, Percent_Identity=32.9815303430079, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=31.7934782608696, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=31.9702602230483, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24662918, Length=387, Percent_Identity=46.2532299741602, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=34.0540540540541, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17137420, Length=355, Percent_Identity=34.9295774647887, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24653280, Length=333, Percent_Identity=30.6306306306306, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653276, Length=333, Percent_Identity=30.6306306306306, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653278, Length=333, Percent_Identity=30.6306306306306, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43266; Mature: 43266

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDYNEFSKELKELEEKGLLVRIRTLQSPQGAWLTIDGKKVLNLCSNNYLGLAFNEELKK
CCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEECHHHHHHHHCCCCEEEEECHHHHH
AAIEAIEKWGVGPGAVRTIAGTLEIHELLEKELAEFKKVEATLVLQSGFNANQAVIPAIT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEC
TAEDAILSDELNHASIIDGVRLSKAKRYVWKHRDAEDLEEKLKQAKAEGSRRLLVITDGV
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCC
FSMDGDLAPLPEIVEKCEKYDALLMVDDAHGEGVLGSHGRGIVDHFDLHGRVDIEVGTLS
EECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCHH
KAFGVVGGFVAGKKDLIDYLKQKARPFLFSSSLSPAETGAALAAVRMLKASDELVKKLWD
HHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NASYFKTEMQKLGFDTGHSETPITPVMLYDAKLSSQFSKKLFEEGIFAQSIGYPTVPKGK
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
ARIRVMISAVHTKEDLDFALGKFKKVGKELGVI
CEEEEEEEHHHCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFDYNEFSKELKELEEKGLLVRIRTLQSPQGAWLTIDGKKVLNLCSNNYLGLAFNEELKK
CCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEECHHHHHHHHCCCCEEEEECHHHHH
AAIEAIEKWGVGPGAVRTIAGTLEIHELLEKELAEFKKVEATLVLQSGFNANQAVIPAIT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEC
TAEDAILSDELNHASIIDGVRLSKAKRYVWKHRDAEDLEEKLKQAKAEGSRRLLVITDGV
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEECCC
FSMDGDLAPLPEIVEKCEKYDALLMVDDAHGEGVLGSHGRGIVDHFDLHGRVDIEVGTLS
EECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCHH
KAFGVVGGFVAGKKDLIDYLKQKARPFLFSSSLSPAETGAALAAVRMLKASDELVKKLWD
HHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
NASYFKTEMQKLGFDTGHSETPITPVMLYDAKLSSQFSKKLFEEGIFAQSIGYPTVPKGK
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
ARIRVMISAVHTKEDLDFALGKFKKVGKELGVI
CEEEEEEEHHHCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA