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The map label for this gene is ldc [H]

Identifier: 239617956

GI number: 239617956

Start: 1698015

End: 1699175

Strand: Direct

Name: ldc [H]

Synonym: Kole_1584

Alternate gene names: 239617956

Gene position: 1698015-1699175 (Clockwise)

Preceding gene: 239617955

Following gene: 239617968

Centisome position: 73.76

GC content: 45.13

Gene sequence:

>1161_bases
GTGGAACTCACCAATGAAATCAGACAGATTTCCAGGGTCCTCCAGACTCCTTTTCTCGTGATGGATCTGAAATATGTAGA
AAAAAATTATTATGATCTGGTTAGGAACATAAAGGATGTTAGGGTTTTTTATGCTGTTAAAGCCAACTCTCATCCAAGAA
TAATTTCCCTTCTTCGCGATCTTGGCAGTTCTTTTGATGTTGCTTCAAGAGGGGAAATAGAGAAATTACTTTCCCTTGAT
GTTCCAGCGGAAAAGCTGAGCTTCGGGAATACAATAAAGAAAGTTGAAGATATAGCTTATGCGCATAGTGTCGGGATAGA
ATATTTTGCCGTTGATTCCGAAATGGAAGTTGAGAAGATCGCCGCTCACGCTCCTGGAAGTAAGGTTTACGGAAGAATTG
CCACAAGTGGAGCCGATAGCGATTGGCCCCTTTCCCGGAAGTTTGGCACCGATGTGGAGCACGTGATTTCTATACTCGAA
TATGCTTCGCGGCTCGGGCTTGACGCCTACGGGGTCTCTTTCCACGTGGGATCGCAGAATTACAGCGTGAAGAATTGGGA
GACGGCTATACAGGACGCCTCGAAGGTCTTCAAGGCTCTTAGGGCCAAAGGAGTTAACCTGCGGATGCTGAATCTCGGTG
GAGGGATACCCGTAAAGCATGTACGGGAAATCCCATCGATAGAAGAGATTGCCGCCTGTATAAACGCTTCCATTGAGAAG
TATCTCGGATTTGTTCCGAACCTCGAGGTCTTCATTGAACCCGGCAGGTCTATGGTCGGAGATGCCGGTATAATGGTGAC
GAGTGTGATATTGAAGAGCAAAAAAGGAAACGAAGATTGGCTGTATATAGATGCAGGTGTTTTTCATGGGTTAACGGAAA
CCATCGAGAATTTCAGGTACGAAGTTATCACCGACGTGGAAGACAACAACTTGAAAACCTTCCACCTTGCTGGGCCAAGC
TGTGATTCAGTGGACACGATCTACGATGACATCAAGTTACCTAGAAGCATCAGTTATGGTGATATCCTTTACTTTTTGAA
TGCCGGTGCTTATACCACGGAATACGGGACGCACTTTAACGGAATAGAACCCCCCAGGATATATTTTGTGGACGAACTTG
TCGAATTCACGGAAAAGAGAGTAAAAAAAGAGGAGCTTTAA

Upstream 100 bases:

>100_bases
AACCTTGATTGCGAAAATGAGAAATCAAATCTTCTCAAATTATACGAAAAAAAGATGATAGAATTTCCCGACACCTGCTT
ATGCCGGGGAGGGATGTTTT

Downstream 100 bases:

>100_bases
AAGCTCCTCTTTTTCATTTTCCGAGAGCACCTTTATATATAAATCTCATAAAGACATCGCTTTTCTTACCCGGAGTGTTT
TTCCAGCCAAAGATATGATA

Product: Ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MELTNEIRQISRVLQTPFLVMDLKYVEKNYYDLVRNIKDVRVFYAVKANSHPRIISLLRDLGSSFDVASRGEIEKLLSLD
VPAEKLSFGNTIKKVEDIAYAHSVGIEYFAVDSEMEVEKIAAHAPGSKVYGRIATSGADSDWPLSRKFGTDVEHVISILE
YASRLGLDAYGVSFHVGSQNYSVKNWETAIQDASKVFKALRAKGVNLRMLNLGGGIPVKHVREIPSIEEIAACINASIEK
YLGFVPNLEVFIEPGRSMVGDAGIMVTSVILKSKKGNEDWLYIDAGVFHGLTETIENFRYEVITDVEDNNLKTFHLAGPS
CDSVDTIYDDIKLPRSISYGDILYFLNAGAYTTEYGTHFNGIEPPRIYFVDELVEFTEKRVKKEEL

Sequences:

>Translated_386_residues
MELTNEIRQISRVLQTPFLVMDLKYVEKNYYDLVRNIKDVRVFYAVKANSHPRIISLLRDLGSSFDVASRGEIEKLLSLD
VPAEKLSFGNTIKKVEDIAYAHSVGIEYFAVDSEMEVEKIAAHAPGSKVYGRIATSGADSDWPLSRKFGTDVEHVISILE
YASRLGLDAYGVSFHVGSQNYSVKNWETAIQDASKVFKALRAKGVNLRMLNLGGGIPVKHVREIPSIEEIAACINASIEK
YLGFVPNLEVFIEPGRSMVGDAGIMVTSVILKSKKGNEDWLYIDAGVFHGLTETIENFRYEVITDVEDNNLKTFHLAGPS
CDSVDTIYDDIKLPRSISYGDILYFLNAGAYTTEYGTHFNGIEPPRIYFVDELVEFTEKRVKKEEL
>Mature_386_residues
MELTNEIRQISRVLQTPFLVMDLKYVEKNYYDLVRNIKDVRVFYAVKANSHPRIISLLRDLGSSFDVASRGEIEKLLSLD
VPAEKLSFGNTIKKVEDIAYAHSVGIEYFAVDSEMEVEKIAAHAPGSKVYGRIATSGADSDWPLSRKFGTDVEHVISILE
YASRLGLDAYGVSFHVGSQNYSVKNWETAIQDASKVFKALRAKGVNLRMLNLGGGIPVKHVREIPSIEEIAACINASIEK
YLGFVPNLEVFIEPGRSMVGDAGIMVTSVILKSKKGNEDWLYIDAGVFHGLTETIENFRYEVITDVEDNNLKTFHLAGPS
CDSVDTIYDDIKLPRSISYGDILYFLNAGAYTTEYGTHFNGIEPPRIYFVDELVEFTEKRVKKEEL

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=32.4468085106383, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI16506287, Length=398, Percent_Identity=30.1507537688442, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI22538418, Length=386, Percent_Identity=28.7564766839378, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI21361583, Length=386, Percent_Identity=28.7564766839378, Blast_Score=152, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17562780, Length=370, Percent_Identity=28.9189189189189, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25141365, Length=389, Percent_Identity=23.6503856041131, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25141367, Length=204, Percent_Identity=25.4901960784314, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=376, Percent_Identity=30.5851063829787, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24586472, Length=364, Percent_Identity=32.1428571428571, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24586474, Length=364, Percent_Identity=32.4175824175824, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 43275; Mature: 43275

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00014 ER_TARGET ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTNEIRQISRVLQTPFLVMDLKYVEKNYYDLVRNIKDVRVFYAVKANSHPRIISLLRD
CCHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHCHHHEEEEEEEECCCCHHHHHHHHH
LGSSFDVASRGEIEKLLSLDVPAEKLSFGNTIKKVEDIAYAHSVGIEYFAVDSEMEVEKI
HCCCCCCCCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
AAHAPGSKVYGRIATSGADSDWPLSRKFGTDVEHVISILEYASRLGLDAYGVSFHVGSQN
HHCCCCCHHEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCEECEEEEECCCC
YSVKNWETAIQDASKVFKALRAKGVNLRMLNLGGGIPVKHVREIPSIEEIAACINASIEK
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHH
YLGFVPNLEVFIEPGRSMVGDAGIMVTSVILKSKKGNEDWLYIDAGVFHGLTETIENFRY
HHCCCCCCEEEEECCCHHHCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCE
EVITDVEDNNLKTFHLAGPSCDSVDTIYDDIKLPRSISYGDILYFLNAGAYTTEYGTHFN
EEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCCCCCC
GIEPPRIYFVDELVEFTEKRVKKEEL
CCCCCCEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELTNEIRQISRVLQTPFLVMDLKYVEKNYYDLVRNIKDVRVFYAVKANSHPRIISLLRD
CCHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHCHHHEEEEEEEECCCCHHHHHHHHH
LGSSFDVASRGEIEKLLSLDVPAEKLSFGNTIKKVEDIAYAHSVGIEYFAVDSEMEVEKI
HCCCCCCCCCCHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
AAHAPGSKVYGRIATSGADSDWPLSRKFGTDVEHVISILEYASRLGLDAYGVSFHVGSQN
HHCCCCCHHEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCEECEEEEECCCC
YSVKNWETAIQDASKVFKALRAKGVNLRMLNLGGGIPVKHVREIPSIEEIAACINASIEK
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHH
YLGFVPNLEVFIEPGRSMVGDAGIMVTSVILKSKKGNEDWLYIDAGVFHGLTETIENFRY
HHCCCCCCEEEEECCCHHHCCHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCE
EVITDVEDNNLKTFHLAGPSCDSVDTIYDDIKLPRSISYGDILYFLNAGAYTTEYGTHFN
EEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCEEECCCCCCC
GIEPPRIYFVDELVEFTEKRVKKEEL
CCCCCCEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]