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The map label for this gene is lon [H]

Identifier: 238923743

GI number: 238923743

Start: 1237451

End: 1238983

Strand: Direct

Name: lon [H]

Synonym: EUBREC_1365

Alternate gene names: 238923743

Gene position: 1237451-1238983 (Clockwise)

Preceding gene: 238923742

Following gene: 238923744

Centisome position: 35.87

GC content: 47.75

Gene sequence:

>1533_bases
TTGACAGGGTATGATGAAGAATACAATTACGAAAAGAGAGGAATAAAAATGCCAGTATTTGATTTTAGCGATACACCGGT
AGCAAACGAGCATCCGGAGTGTACATATGAGACATTTCATTCGACAGAGACCAGGGCATCGGCCGATAAACCGATTGTTG
TGATAGACAATAAGCAAAAGGAGTGGGCGCACCATGCGCTCGGTATGTTTACAAATCCGATAAAGCGTACATCCTTTGAA
TTTGAGGATGGTGATGGGGTGACCAGTGCAGATATCCTGCGCATTGATTCCCGCTTCGTTAGCCTTTTTAAGTGGCTTGG
CGAAAATCACATAAAGGTACAGCTTTCAGGAGCCAATACACCTGACGGATACGCAGTATACAGGGTGAGGGAGGTGGCTC
TCGGCAGAGGCACAAAGCTGTCTGCAGAGGACGGATTCCTGCAGTATATGATGGAAAGGCTCTTTGCCAGCACCATGCCT
GAGGATGAACCCGACCTCGATGATTACGAGGAAGAGGGCGACAGCATGAAGCTCACCAGTATACAGAGCATCACAGATTT
CATGACCTGTGCAGGCCGTACACTGCCTGACAATATACTGCTGTGGGCCAGAAGAAATCTGGCAGTTGCGCGTTCAAGCG
AGGTATCACCTGAGGAGAGACGCCATGCGCAGAGAGCACTTTCCATCATGATGAATATCCAGTGGAAGGGAAATTACTTT
GAGGCAATTGACCCTGTGGAGGCAAGGCGCATACTCGATGAGGAGCTCTATGGAATGGAGAGCGTGAAGCAGAGAATCAT
TGAGACCATTATCCAGATAAACAGGACTCATACACTTCCTGCCTACGGACTGCTTCTCTGTGGACCGGCAGGAACCGGAA
AGTCACAGATTGCATATGCTGTTGCACGTATACTCAAGCTTCCATGGACCACACTCGATATGAGCTCCATAAATGATGCA
GAGCAGCTCACAGGAAGCTCAAGAATCTATTCAAATGCAAAGCCGGGAATCATTATGGAGGCATTTTCACAGGCGGGAGA
GTCAAATCTTGTATTTATCATCAATGAGCTCGACAAGGCCTCAAGCAAAAACGGTAACGGAAATCCGGCAGATGTGCTTT
TGACACTGCTTGACAATCTGGGCTTTACAGACAACTATATGGAGTGTATGGTGCCGACCGTCGGAGTATATCCGATTGCA
ACAGCCAATGATAAATCCCAGATTTCTGCACCGCTTATGTCACGTTTTGCGGTGATTGATATTCCGGACTATACCGATGA
AGAGAAGAAGGTCATCTTCCAGCGATTTGCCCTGCGCAAGGTATTTGAGCGAATGGGAATGAAGGAGGAGGAGTGCGTTC
TCACAGAGGACGGACTTGATGCAGTGATTAAGCTTCACGAGAACACATCGGGCATAAGAGATCTCGAGCAGGCTGCAGAG
CATCTGGCAGCAAATGCACTTTATCAGATAGAGGTTGATAAGGTGAAGCAGGTGGTATTTGACGCTGAGGCTGTTTTTGA
GCTTTTAGGCTAG

Upstream 100 bases:

>100_bases
CACAAGTGCACGCAGCGCAGGGATATTCCCGGAAGCCTTGCATTTGTACCATCAGTGGCAGGACTTATCATCGCGGGCGA
GGTGGTACAGGACATAGCCT

Downstream 100 bases:

>100_bases
CAGGATATGATTACGGATACAGGAATTGTTACGAAAATAAAAGGAGATTGTCAGGATGAGAGAATTTGGAAAATCCAGAA
AATTAGATAATGTGCTTTAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTGYDEEYNYEKRGIKMPVFDFSDTPVANEHPECTYETFHSTETRASADKPIVVIDNKQKEWAHHALGMFTNPIKRTSFE
FEDGDGVTSADILRIDSRFVSLFKWLGENHIKVQLSGANTPDGYAVYRVREVALGRGTKLSAEDGFLQYMMERLFASTMP
EDEPDLDDYEEEGDSMKLTSIQSITDFMTCAGRTLPDNILLWARRNLAVARSSEVSPEERRHAQRALSIMMNIQWKGNYF
EAIDPVEARRILDEELYGMESVKQRIIETIIQINRTHTLPAYGLLLCGPAGTGKSQIAYAVARILKLPWTTLDMSSINDA
EQLTGSSRIYSNAKPGIIMEAFSQAGESNLVFIINELDKASSKNGNGNPADVLLTLLDNLGFTDNYMECMVPTVGVYPIA
TANDKSQISAPLMSRFAVIDIPDYTDEEKKVIFQRFALRKVFERMGMKEEECVLTEDGLDAVIKLHENTSGIRDLEQAAE
HLAANALYQIEVDKVKQVVFDAEAVFELLG

Sequences:

>Translated_510_residues
MTGYDEEYNYEKRGIKMPVFDFSDTPVANEHPECTYETFHSTETRASADKPIVVIDNKQKEWAHHALGMFTNPIKRTSFE
FEDGDGVTSADILRIDSRFVSLFKWLGENHIKVQLSGANTPDGYAVYRVREVALGRGTKLSAEDGFLQYMMERLFASTMP
EDEPDLDDYEEEGDSMKLTSIQSITDFMTCAGRTLPDNILLWARRNLAVARSSEVSPEERRHAQRALSIMMNIQWKGNYF
EAIDPVEARRILDEELYGMESVKQRIIETIIQINRTHTLPAYGLLLCGPAGTGKSQIAYAVARILKLPWTTLDMSSINDA
EQLTGSSRIYSNAKPGIIMEAFSQAGESNLVFIINELDKASSKNGNGNPADVLLTLLDNLGFTDNYMECMVPTVGVYPIA
TANDKSQISAPLMSRFAVIDIPDYTDEEKKVIFQRFALRKVFERMGMKEEECVLTEDGLDAVIKLHENTSGIRDLEQAAE
HLAANALYQIEVDKVKQVVFDAEAVFELLG
>Mature_509_residues
TGYDEEYNYEKRGIKMPVFDFSDTPVANEHPECTYETFHSTETRASADKPIVVIDNKQKEWAHHALGMFTNPIKRTSFEF
EDGDGVTSADILRIDSRFVSLFKWLGENHIKVQLSGANTPDGYAVYRVREVALGRGTKLSAEDGFLQYMMERLFASTMPE
DEPDLDDYEEEGDSMKLTSIQSITDFMTCAGRTLPDNILLWARRNLAVARSSEVSPEERRHAQRALSIMMNIQWKGNYFE
AIDPVEARRILDEELYGMESVKQRIIETIIQINRTHTLPAYGLLLCGPAGTGKSQIAYAVARILKLPWTTLDMSSINDAE
QLTGSSRIYSNAKPGIIMEAFSQAGESNLVFIINELDKASSKNGNGNPADVLLTLLDNLGFTDNYMECMVPTVGVYPIAT
ANDKSQISAPLMSRFAVIDIPDYTDEEKKVIFQRFALRKVFERMGMKEEECVLTEDGLDAVIKLHENTSGIRDLEQAAEH
LAANALYQIEVDKVKQVVFDAEAVFELLG

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=290, Percent_Identity=31.0344827586207, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI31377667, Length=284, Percent_Identity=28.5211267605634, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1786643, Length=285, Percent_Identity=30.1754385964912, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17505831, Length=248, Percent_Identity=32.258064516129, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17556486, Length=267, Percent_Identity=28.0898876404494, Blast_Score=115, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319449, Length=329, Percent_Identity=28.2674772036474, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24666867, Length=269, Percent_Identity=28.6245353159851, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI221513036, Length=269, Percent_Identity=28.6245353159851, Blast_Score=122, Evalue=8e-28,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 57319; Mature: 57188

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYDEEYNYEKRGIKMPVFDFSDTPVANEHPECTYETFHSTETRASADKPIVVIDNKQK
CCCCCCCCCHHHCCCCCCEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEECCCH
EWAHHALGMFTNPIKRTSFEFEDGDGVTSADILRIDSRFVSLFKWLGENHIKVQLSGANT
HHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
PDGYAVYRVREVALGRGTKLSAEDGFLQYMMERLFASTMPEDEPDLDDYEEEGDSMKLTS
CCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEHH
IQSITDFMTCAGRTLPDNILLWARRNLAVARSSEVSPEERRHAQRALSIMMNIQWKGNYF
HHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHEEEECCCCC
EAIDPVEARRILDEELYGMESVKQRIIETIIQINRTHTLPAYGLLLCGPAGTGKSQIAYA
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHH
VARILKLPWTTLDMSSINDAEQLTGSSRIYSNAKPGIIMEAFSQAGESNLVFIINELDKA
HHHHHHCCCCEECHHCCCCHHHHCCCHHEECCCCCCHHHHHHHHCCCCCEEEEEECHHHH
SSKNGNGNPADVLLTLLDNLGFTDNYMECMVPTVGVYPIATANDKSQISAPLMSRFAVID
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHHCEEEEE
IPDYTDEEKKVIFQRFALRKVFERMGMKEEECVLTEDGLDAVIKLHENTSGIRDLEQAAE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
HLAANALYQIEVDKVKQVVFDAEAVFELLG
HHHHHCEEEEEHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TGYDEEYNYEKRGIKMPVFDFSDTPVANEHPECTYETFHSTETRASADKPIVVIDNKQK
CCCCCCCCHHHCCCCCCEECCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEECCCH
EWAHHALGMFTNPIKRTSFEFEDGDGVTSADILRIDSRFVSLFKWLGENHIKVQLSGANT
HHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
PDGYAVYRVREVALGRGTKLSAEDGFLQYMMERLFASTMPEDEPDLDDYEEEGDSMKLTS
CCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEHH
IQSITDFMTCAGRTLPDNILLWARRNLAVARSSEVSPEERRHAQRALSIMMNIQWKGNYF
HHHHHHHHHHCCCCCCCCEEEEECCCEEEECCCCCCHHHHHHHHHHHHHHHEEEECCCCC
EAIDPVEARRILDEELYGMESVKQRIIETIIQINRTHTLPAYGLLLCGPAGTGKSQIAYA
CCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHH
VARILKLPWTTLDMSSINDAEQLTGSSRIYSNAKPGIIMEAFSQAGESNLVFIINELDKA
HHHHHHCCCCEECHHCCCCHHHHCCCHHEECCCCCCHHHHHHHHCCCCCEEEEEECHHHH
SSKNGNGNPADVLLTLLDNLGFTDNYMECMVPTVGVYPIATANDKSQISAPLMSRFAVID
CCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCEEEECCCCHHHHHHHHHHCEEEEE
IPDYTDEEKKVIFQRFALRKVFERMGMKEEECVLTEDGLDAVIKLHENTSGIRDLEQAAE
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHH
HLAANALYQIEVDKVKQVVFDAEAVFELLG
HHHHHCEEEEEHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA