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The map label for this gene is thyA [H]

Identifier: 238923626

GI number: 238923626

Start: 1145296

End: 1146144

Strand: Direct

Name: thyA [H]

Synonym: EUBREC_1248

Alternate gene names: 238923626

Gene position: 1145296-1146144 (Clockwise)

Preceding gene: 238923623

Following gene: 238923627

Centisome position: 33.2

GC content: 43.58

Gene sequence:

>849_bases
ATGAGTTATGCAGATAAAGTTTTTGTAGCGATGTGTCAGGACATTCTGGAAAATGGCACAAGCACTGAGGGAGAGCTGGT
GCGTCCCCACTGGGAGGATGGCACAAGCGCCTATACAATAAAGAAGTTTGGTGTCGTCAACAGATATGATTTGTCAAAGG
AATTTCCGGCTATCACTTTAAGAAAGACATATATCAAGAGTGCAACGGATGAGCTTCTTTGGATATGGCAGAAGAAATCC
AACAATATCCATGATTTAAAAAGCCATGTGTGGGATGAGTGGGCAGATGAGGATGGTTCAATCGGCAAGGCCTACGGATA
TCAGCTTGGTGTAAAGCATCAATATAAGGAAGGCATGATGGATCAGGTGGACAGAGTCATTTATGATTTGAAGCATACAC
CTTTTTCAAGAAGAATACTTACCAATATATATGTGCATCAGGATCTGCATGAGATGAATCTGTATCCGTGCGCATACAGC
ATGACATTCAACGTGACACAGAAAAAGGGTGATGACAGGCTCACATTAAATGGTATCTTAAACCAGCGCTCACAGGATGT
GCTTGCGGCGAACAACTGGAATGTATGCCAGTATGCGGTGCTTATGCATATGCTGGCGCAGGTGTGTGATATGAGAGTCG
GAGAGCTGGTGCACGTGATTGCAGATGCACACATTTACGACAGGCATGTGCCAATTGTGAAGGAGCTGATTGAGAGACCA
CAGTACGATGCTCCAAAGTTCTGGCTCAATCCTGACATAAAGGATTTCTATCAGTTTACGACCGATGATATCAAGATAAC
AGACTATGTGACAGGTGAGCAGATTAAGGATATACCTATTGCGGTTTAA

Upstream 100 bases:

>100_bases
TGCACATTGAATATATTGAAAAAAAATTGATAATTAGATACAATAGACAGTAAACGGGTAATTGTATCGGTTGAATACTT
ATGATTAGGGAGCAGATAAT

Downstream 100 bases:

>100_bases
AGAATGTGGATATGAAGCAGTTATAAGAAGGTTATTGTTCACTACTTTGTGTGAACAGCAACGATTACAACAGGGAGAAA
ATCATGAATTTAATAGCAGC

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSYADKVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYIKSATDELLWIWQKKS
NNIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQVDRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYS
MTFNVTQKKGDDRLTLNGILNQRSQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERP
QYDAPKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV

Sequences:

>Translated_282_residues
MSYADKVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYIKSATDELLWIWQKKS
NNIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQVDRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYS
MTFNVTQKKGDDRLTLNGILNQRSQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERP
QYDAPKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV
>Mature_281_residues
SYADKVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYIKSATDELLWIWQKKSN
NIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQVDRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSM
TFNVTQKKGDDRLTLNGILNQRSQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERPQ
YDAPKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507751, Length=268, Percent_Identity=29.8507462686567, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1789191, Length=279, Percent_Identity=31.1827956989247, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71993377, Length=285, Percent_Identity=30.1754385964912, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324648, Length=182, Percent_Identity=34.6153846153846, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17137556, Length=266, Percent_Identity=30.0751879699248, Blast_Score=131, Evalue=4e-31,

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 32833; Mature: 32701

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYADKVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITL
CCHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEH
RKTYIKSATDELLWIWQKKSNNIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMM
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHCEEECCCHHHHHHHH
DQVDRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSMTFNVTQKKGDDRLTLNGIL
HHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCEEEEEEEEEECCCCCCEEEEHHHH
NQRSQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERP
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
QYDAPKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV
CCCCCCEECCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SYADKVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITL
CHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEH
RKTYIKSATDELLWIWQKKSNNIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMM
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHCEEECCCHHHHHHHH
DQVDRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSMTFNVTQKKGDDRLTLNGIL
HHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCEEEEEEEEEECCCCCCEEEEHHHH
NQRSQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERP
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
QYDAPKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV
CCCCCCEECCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA