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The map label for this gene is fabG [C]

Identifier: 238923623

GI number: 238923623

Start: 1143222

End: 1143911

Strand: Direct

Name: fabG [C]

Synonym: EUBREC_1245

Alternate gene names: 238923623

Gene position: 1143222-1143911 (Clockwise)

Preceding gene: 238923622

Following gene: 238923626

Centisome position: 33.14

GC content: 42.32

Gene sequence:

>690_bases
ATGAACAAAGCAATTGTAACCGGGGCGTCTTCCGGAATCGGAAAAGCTATATGCAGGCAGCTTGCAGCGAATGGCTGGCT
GGTTTACGGAATAGGAAGAAGCTTCAATCAAAGTGATGATATCGCAGGGATAGAGCGTATAGTATGCGATATTACCGATA
CCGCAAAGCTCATCAAGACAATAAAAGAAATTAATAAAAATCATGATATATCACTTCTCATAAACAATGCAGGAGTCGGC
TTTTACGCGCTTCATGAGGAACTTAATCCTGTAAAAATATCACAGATGGTGAGGACAAATCTTGAGGCACCGATGATTAT
CACAAATTTGCTGCTTCGCGATTTAAAGAAAAACAAAGGAACAATAATAAATATCTCATCAATCACTGCTGAAAAGACGA
ATCCGCACGGCTGTGCCTATGGTGCCACAAAGGCAGGGCTTACGAGCTTTTCCCACAGCCTGTTTGAGGAGGCGAGAAAG
TACGGTGTGCGTGTGGTAAATTTAGAGCCTGATATGACCGATACCAATCTGTACAGGAATGCTGATTTTACAGTGGATGA
AAATGAAGCTGCAAGAATACAGCCAAATGAGGTTGCAGACGCAGTGCTTTATGTTTTAGGGCAAAGAGAAGGCCTTGTGA
TGACAGATATCACCATAAGGCCACAGCTTCACAGAATTGCAAGAAAGTAA

Upstream 100 bases:

>100_bases
AGGACAGGATATTTATGTGGAAGTGATATTATTGCAATACATTTTCAATATATATATCACATGGTATGATTAAAGGGTCA
AAGTATAAAGGAGCAATCAG

Downstream 100 bases:

>100_bases
AGTGTTTATATTTTAAAAAGCATCAAATGCCATTCGAACGATTGACTTATAGTCATTAAGCGTCTGGCATTTTTTAATTT
TCTTCCAGAGCTTTTCAGAG

Product: putative short-chain dehydrogenases/reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MNKAIVTGASSGIGKAICRQLAANGWLVYGIGRSFNQSDDIAGIERIVCDITDTAKLIKTIKEINKNHDISLLINNAGVG
FYALHEELNPVKISQMVRTNLEAPMIITNLLLRDLKKNKGTIINISSITAEKTNPHGCAYGATKAGLTSFSHSLFEEARK
YGVRVVNLEPDMTDTNLYRNADFTVDENEAARIQPNEVADAVLYVLGQREGLVMTDITIRPQLHRIARK

Sequences:

>Translated_229_residues
MNKAIVTGASSGIGKAICRQLAANGWLVYGIGRSFNQSDDIAGIERIVCDITDTAKLIKTIKEINKNHDISLLINNAGVG
FYALHEELNPVKISQMVRTNLEAPMIITNLLLRDLKKNKGTIINISSITAEKTNPHGCAYGATKAGLTSFSHSLFEEARK
YGVRVVNLEPDMTDTNLYRNADFTVDENEAARIQPNEVADAVLYVLGQREGLVMTDITIRPQLHRIARK
>Mature_229_residues
MNKAIVTGASSGIGKAICRQLAANGWLVYGIGRSFNQSDDIAGIERIVCDITDTAKLIKTIKEINKNHDISLLINNAGVG
FYALHEELNPVKISQMVRTNLEAPMIITNLLLRDLKKNKGTIINISSITAEKTNPHGCAYGATKAGLTSFSHSLFEEARK
YGVRVVNLEPDMTDTNLYRNADFTVDENEAARIQPNEVADAVLYVLGQREGLVMTDITIRPQLHRIARK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI226371731, Length=193, Percent_Identity=30.5699481865285, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=26.8595041322314, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI150247226, Length=188, Percent_Identity=28.1914893617021, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4504503, Length=226, Percent_Identity=27.4336283185841, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20149619, Length=229, Percent_Identity=25.764192139738, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI40254992, Length=214, Percent_Identity=26.1682242990654, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4557649, Length=201, Percent_Identity=32.3383084577114, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7705855, Length=199, Percent_Identity=30.6532663316583, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI44680136, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI44680133, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI17738292, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=183, Percent_Identity=32.2404371584699, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787820, Length=217, Percent_Identity=27.6497695852535, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1786812, Length=219, Percent_Identity=25.1141552511416, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=232, Percent_Identity=26.7241379310345, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=206, Percent_Identity=31.0679611650485, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=245, Percent_Identity=26.9387755102041, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322067, Length=175, Percent_Identity=30.2857142857143, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=196, Percent_Identity=32.6530612244898, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639444, Length=219, Percent_Identity=27.8538812785388, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI116007236, Length=241, Percent_Identity=27.8008298755187, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24584752, Length=186, Percent_Identity=30.1075268817204, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24640442, Length=191, Percent_Identity=28.7958115183246, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=30.6878306878307, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007234, Length=239, Percent_Identity=27.6150627615063, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24643142, Length=225, Percent_Identity=29.3333333333333, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24663911, Length=240, Percent_Identity=24.5833333333333, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648944, Length=239, Percent_Identity=27.1966527196653, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571526, Length=199, Percent_Identity=29.1457286432161, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641232, Length=239, Percent_Identity=24.2677824267782, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644339, Length=184, Percent_Identity=29.8913043478261, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281364494, Length=240, Percent_Identity=25.8333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641388, Length=240, Percent_Identity=25, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 25208; Mature: 25208

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAIVTGASSGIGKAICRQLAANGWLVYGIGRSFNQSDDIAGIERIVCDITDTAKLIKT
CCCEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
IKEINKNHDISLLINNAGVGFYALHEELNPVKISQMVRTNLEAPMIITNLLLRDLKKNKG
HHHHCCCCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
TIINISSITAEKTNPHGCAYGATKAGLTSFSHSLFEEARKYGVRVVNLEPDMTDTNLYRN
CEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEC
ADFTVDENEAARIQPNEVADAVLYVLGQREGLVMTDITIRPQLHRIARK
CCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHCC
>Mature Secondary Structure
MNKAIVTGASSGIGKAICRQLAANGWLVYGIGRSFNQSDDIAGIERIVCDITDTAKLIKT
CCCEEEECCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHH
IKEINKNHDISLLINNAGVGFYALHEELNPVKISQMVRTNLEAPMIITNLLLRDLKKNKG
HHHHCCCCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
TIINISSITAEKTNPHGCAYGATKAGLTSFSHSLFEEARKYGVRVVNLEPDMTDTNLYRN
CEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEC
ADFTVDENEAARIQPNEVADAVLYVLGQREGLVMTDITIRPQLHRIARK
CCCEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]