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The map label for this gene is csd [H]

Identifier: 238921895

GI number: 238921895

Start: 104002

End: 105231

Strand: Reverse

Name: csd [H]

Synonym: EUBELI_20129

Alternate gene names: 238921895

Gene position: 105231-104002 (Counterclockwise)

Preceding gene: 238921896

Following gene: 238921894

Centisome position: 16.79

GC content: 39.59

Gene sequence:

>1230_bases
ATGAGTGAGTTAAGTAAGACGATTGAGTCTATAAGAAAAGATTTCCCACTTATTTCGGGAAGCAATATTGCATATCTTGA
TAATGCAGCGACTACACAGAAGCCACAGGCTGTTCTTGATGCAGTTAATAAGTATTATCAGGAGATGAACGCCAATCCGT
TCAGAGGTGTATACGAATTAAGTGAGATTGCTACAGAAAGTTATGAGAATGCAAGAAAGGCAGTAGCTCAGTTTATTGGT
GCTAAAGATGCAAGCCAGATAGTATTTACAAGAAATGCTACAGAGAGTCTTAACTTAATTGCATACAGTTATGGAATGAA
TTTCATTAAAGAGGGTGATGAGATTGTTGTTAGTGTTATGGAACACCACAGCAATTTCCTTCCATGGAAGCAGGTTGCAG
AAAAATGTGGAGCGGTATTAAAGCAGCTTACACCTGATGAGAATGGAGAGATTACAGACAAGTCTTTAGAGGTTATCACA
GATAAGACTAGGCTTGTAGCAGTTACCCAGGTTTCTAATGTATTAGGAAGAGTTAATGATATAAAGCATATTGCAGAGGT
TGCACATGCACATGGTGCGGTTATTGTGGCTGACGGAGCACAGAGTGTTCCTCATATGCCGGTTAATGTAACAGACCTTG
ATGTTGACTTCCTTGTATTTTCTGGACATAAGATGTTAGCACCTATGGGAATAGGAGCATTATATGGCAAGAAAGATATT
CTTGACAAGATGCCACCATTCTTAAGCGGTGGTGAGATGATTGAGATTGTTCACTGGGACAGAGTTAAATATGCAGAGGT
TCCACATAAGTTTGAGGCAGGAACTGTTAATACTGGCGGTGCAGTCGGACTTCATGCGGCAATTGATTATATTAACAATG
TTGGATTTGACACAATTATGGCACAGGAGCGAAAGCTTACTAAGATTGCTGTTGATGCCATTAATGACATGAAGGGAGTC
AACTTAATAGGTTCTTCGAAGGCAGAAGACCATGAGGGTATAGTCACATTTACAATTGACGGAGTACACCCACATGATGT
TGCTTCTATACTTGATTCACAGCATATTGCAGTAAGAGCAGGACATCACTGTGCACAGCCATTAATGGATTTCCTTAAGG
TTAATTCAACAACGAGAGCAAGCTTTGCTTTCTATAATACAGAAGAAGAAGTACAGCATTTTATAGAAGAACTATCTAAG
ATCAGGGGGCTTATGGGATATGGAGACTAA

Upstream 100 bases:

>100_bases
ATAATATGCTGGCAGCAGCTAAGCTTTTAGCTGTATGCGGCAAAATCCCTGATGATGGTATCAGGAACGAGATACATGAC
TACATTAAAGAGGTTTATTA

Downstream 100 bases:

>100_bases
AACTTTTTATAATGAGGTTCTTACGGATCATAACATGCATCCATATCATAAGCATGATATAGACAATGCAGACTTAGAGC
TTGAGGGTGTTAATCCAAGC

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSELSKTIESIRKDFPLISGSNIAYLDNAATTQKPQAVLDAVNKYYQEMNANPFRGVYELSEIATESYENARKAVAQFIG
AKDASQIVFTRNATESLNLIAYSYGMNFIKEGDEIVVSVMEHHSNFLPWKQVAEKCGAVLKQLTPDENGEITDKSLEVIT
DKTRLVAVTQVSNVLGRVNDIKHIAEVAHAHGAVIVADGAQSVPHMPVNVTDLDVDFLVFSGHKMLAPMGIGALYGKKDI
LDKMPPFLSGGEMIEIVHWDRVKYAEVPHKFEAGTVNTGGAVGLHAAIDYINNVGFDTIMAQERKLTKIAVDAINDMKGV
NLIGSSKAEDHEGIVTFTIDGVHPHDVASILDSQHIAVRAGHHCAQPLMDFLKVNSTTRASFAFYNTEEEVQHFIEELSK
IRGLMGYGD

Sequences:

>Translated_409_residues
MSELSKTIESIRKDFPLISGSNIAYLDNAATTQKPQAVLDAVNKYYQEMNANPFRGVYELSEIATESYENARKAVAQFIG
AKDASQIVFTRNATESLNLIAYSYGMNFIKEGDEIVVSVMEHHSNFLPWKQVAEKCGAVLKQLTPDENGEITDKSLEVIT
DKTRLVAVTQVSNVLGRVNDIKHIAEVAHAHGAVIVADGAQSVPHMPVNVTDLDVDFLVFSGHKMLAPMGIGALYGKKDI
LDKMPPFLSGGEMIEIVHWDRVKYAEVPHKFEAGTVNTGGAVGLHAAIDYINNVGFDTIMAQERKLTKIAVDAINDMKGV
NLIGSSKAEDHEGIVTFTIDGVHPHDVASILDSQHIAVRAGHHCAQPLMDFLKVNSTTRASFAFYNTEEEVQHFIEELSK
IRGLMGYGD
>Mature_408_residues
SELSKTIESIRKDFPLISGSNIAYLDNAATTQKPQAVLDAVNKYYQEMNANPFRGVYELSEIATESYENARKAVAQFIGA
KDASQIVFTRNATESLNLIAYSYGMNFIKEGDEIVVSVMEHHSNFLPWKQVAEKCGAVLKQLTPDENGEITDKSLEVITD
KTRLVAVTQVSNVLGRVNDIKHIAEVAHAHGAVIVADGAQSVPHMPVNVTDLDVDFLVFSGHKMLAPMGIGALYGKKDIL
DKMPPFLSGGEMIEIVHWDRVKYAEVPHKFEAGTVNTGGAVGLHAAIDYINNVGFDTIMAQERKLTKIAVDAINDMKGVN
LIGSSKAEDHEGIVTFTIDGVHPHDVASILDSQHIAVRAGHHCAQPLMDFLKVNSTTRASFAFYNTEEEVQHFIEELSKI
RGLMGYGD

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=389, Percent_Identity=25.9640102827763, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156713448, Length=300, Percent_Identity=28.6666666666667, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=42.3645320197044, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI1789175, Length=397, Percent_Identity=39.2947103274559, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193211090, Length=369, Percent_Identity=26.5582655826558, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=398, Percent_Identity=26.3819095477387, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6319831, Length=398, Percent_Identity=26.3819095477387, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129463, Length=290, Percent_Identity=30, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44842; Mature: 44711

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSKTIESIRKDFPLISGSNIAYLDNAATTQKPQAVLDAVNKYYQEMNANPFRGVYEL
CCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
SEIATESYENARKAVAQFIGAKDASQIVFTRNATESLNLIAYSYGMNFIKEGDEIVVSVM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHEEEEEECCCHHHHCCHHHHHHHH
EHHSNFLPWKQVAEKCGAVLKQLTPDENGEITDKSLEVITDKTRLVAVTQVSNVLGRVND
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECCHHEEEHHHHHHHHHHHHH
IKHIAEVAHAHGAVIVADGAQSVPHMPVNVTDLDVDFLVFSGHKMLAPMGIGALYGKKDI
HHHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCEEEEEECCCCEECCCCCHHHCCCHHH
LDKMPPFLSGGEMIEIVHWDRVKYAEVPHKFEAGTVNTGGAVGLHAAIDYINNVGFDTIM
HHHCCCCCCCCCEEEEEECCCEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHH
AQERKLTKIAVDAINDMKGVNLIGSSKAEDHEGIVTFTIDGVHPHDVASILDSQHIAVRA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEC
GHHCAQPLMDFLKVNSTTRASFAFYNTEEEVQHFIEELSKIRGLMGYGD
CCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SELSKTIESIRKDFPLISGSNIAYLDNAATTQKPQAVLDAVNKYYQEMNANPFRGVYEL
CHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHH
SEIATESYENARKAVAQFIGAKDASQIVFTRNATESLNLIAYSYGMNFIKEGDEIVVSVM
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHEEEEEECCCHHHHCCHHHHHHHH
EHHSNFLPWKQVAEKCGAVLKQLTPDENGEITDKSLEVITDKTRLVAVTQVSNVLGRVND
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHEECCHHEEEHHHHHHHHHHHHH
IKHIAEVAHAHGAVIVADGAQSVPHMPVNVTDLDVDFLVFSGHKMLAPMGIGALYGKKDI
HHHHHHHHHHCCEEEEECCCCCCCCCCCCEEECCEEEEEECCCCEECCCCCHHHCCCHHH
LDKMPPFLSGGEMIEIVHWDRVKYAEVPHKFEAGTVNTGGAVGLHAAIDYINNVGFDTIM
HHHCCCCCCCCCEEEEEECCCEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHH
AQERKLTKIAVDAINDMKGVNLIGSSKAEDHEGIVTFTIDGVHPHDVASILDSQHIAVRA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEEEC
GHHCAQPLMDFLKVNSTTRASFAFYNTEEEVQHFIEELSKIRGLMGYGD
CCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]