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The map label for this gene is proC [H]

Identifier: 238921618

GI number: 238921618

Start: 3658331

End: 3659140

Strand: Reverse

Name: proC [H]

Synonym: NT01EI_3773

Alternate gene names: 238921618

Gene position: 3659140-3658331 (Counterclockwise)

Preceding gene: 238921619

Following gene: 238921617

Centisome position: 95.98

GC content: 61.73

Gene sequence:

>810_bases
GTGGAGCAGAAAATCGGGTTTATTGGCTGCGGTAACATGGGCAAGGCCATACTGGGGGGGCTGTTGGCCAGTCAGTTTGC
GCGGCCGCAGGATATTCTGGTGTATAACCGTACCGCTGACAGCGTCAGGGCGATTGTCGATGAATATGGCGTTGGCGCGG
CCGCCGGTGCACAGGCGTTGGCCGCCGCGGTGGATATCGTGGTGCTGGGTGTTAAACCCAGTGGAATGCGGGCGTTGCTG
GAGGAGATTAAAGGGAGTCTGCGGGCTGAGACTATCGTCGTCTCTATTGCAGCCGGCGTGACGATCGAGACCCTCCAGGA
AGGTCTGCCGGTGCAGCAGAAGGTGATTCGGGTGATGCCCAACACGCCCTCGCTGGTCAATGCCGGAATGTCATCTGTAA
CCCCGAACGGGCGGGTCAGCGCCGAAGAGTGTGCCCGGATCGTCGCCTTGTTCCGCAGCTTCGGACGGGCAGAGGTCGTG
CCCGAGTCGCTGATCCATGCCGTGGTTGGGGTGAGTGGATCGTCACCGGCCTATGTGTTCATGTTTATTGAAGCGATGGC
CGATGCGGTGGTTCGCGCCGGGATGCCCCGGGCTCAGGCCTATCAGTTTGCGGCCCAGGCGGTGATGGGAGCTGCAAAAA
TGGTGCTGGAAACCGGTACGCATCCGGCGGAGCTGAAGGATATGGTATGTTCGCCGGGCGGTACGACCATTGAGGCGGTG
GCCGCGCTGGAGGAGAACGGCATGCGTGCGTCGGTGATCGAGGCTATCACCCGCTGTATCGCGAAGTCGGAGGCGATGAG
CCGCCGCTGA

Upstream 100 bases:

>100_bases
TGACATATTTTTCCACGGCGCTTGATGGTAGGCTTGACGCAAGGTGGCATGCTGCATCGGGTGCACTGTCTTAATGATGA
AATACTGGGCTGGAGGTTAC

Downstream 100 bases:

>100_bases
GTAGGGCGGTATCTCTGGCGCTGCCGCGGCGGCGCCGGTTCCTTGCGCGGCAGCGCCGTCTATTCCATTTTCCCCCGTAT
ATACGCTGCTGATTTGTTTT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MEQKIGFIGCGNMGKAILGGLLASQFARPQDILVYNRTADSVRAIVDEYGVGAAAGAQALAAAVDIVVLGVKPSGMRALL
EEIKGSLRAETIVVSIAAGVTIETLQEGLPVQQKVIRVMPNTPSLVNAGMSSVTPNGRVSAEECARIVALFRSFGRAEVV
PESLIHAVVGVSGSSPAYVFMFIEAMADAVVRAGMPRAQAYQFAAQAVMGAAKMVLETGTHPAELKDMVCSPGGTTIEAV
AALEENGMRASVIEAITRCIAKSEAMSRR

Sequences:

>Translated_269_residues
MEQKIGFIGCGNMGKAILGGLLASQFARPQDILVYNRTADSVRAIVDEYGVGAAAGAQALAAAVDIVVLGVKPSGMRALL
EEIKGSLRAETIVVSIAAGVTIETLQEGLPVQQKVIRVMPNTPSLVNAGMSSVTPNGRVSAEECARIVALFRSFGRAEVV
PESLIHAVVGVSGSSPAYVFMFIEAMADAVVRAGMPRAQAYQFAAQAVMGAAKMVLETGTHPAELKDMVCSPGGTTIEAV
AALEENGMRASVIEAITRCIAKSEAMSRR
>Mature_269_residues
MEQKIGFIGCGNMGKAILGGLLASQFARPQDILVYNRTADSVRAIVDEYGVGAAAGAQALAAAVDIVVLGVKPSGMRALL
EEIKGSLRAETIVVSIAAGVTIETLQEGLPVQQKVIRVMPNTPSLVNAGMSSVTPNGRVSAEECARIVALFRSFGRAEVV
PESLIHAVVGVSGSSPAYVFMFIEAMADAVVRAGMPRAQAYQFAAQAVMGAAKMVLETGTHPAELKDMVCSPGGTTIEAV
AALEENGMRASVIEAITRCIAKSEAMSRR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=36.3295880149813, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=39.0334572490706, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=36.5671641791045, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=36.5671641791045, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=63.8059701492537, Blast_Score=344, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=37.9182156133829, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=34.8754448398576, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=280, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24648116, Length=278, Percent_Identity=38.8489208633094, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21358587, Length=261, Percent_Identity=39.0804597701149, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=42.0118343195266, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27992; Mature: 27992

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKIGFIGCGNMGKAILGGLLASQFARPQDILVYNRTADSVRAIVDEYGVGAAAGAQAL
CCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHH
AAAVDIVVLGVKPSGMRALLEEIKGSLRAETIVVSIAAGVTIETLQEGLPVQQKVIRVMP
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHEEEHHCCCCHHHHHCCCCHHHHHHHHCC
NTPSLVNAGMSSVTPNGRVSAEECARIVALFRSFGRAEVVPESLIHAVVGVSGSSPAYVF
CCCHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHH
MFIEAMADAVVRAGMPRAQAYQFAAQAVMGAAKMVLETGTHPAELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHH
AALEENGMRASVIEAITRCIAKSEAMSRR
HHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEQKIGFIGCGNMGKAILGGLLASQFARPQDILVYNRTADSVRAIVDEYGVGAAAGAQAL
CCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHH
AAAVDIVVLGVKPSGMRALLEEIKGSLRAETIVVSIAAGVTIETLQEGLPVQQKVIRVMP
HHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHEEEHHCCCCHHHHHCCCCHHHHHHHHCC
NTPSLVNAGMSSVTPNGRVSAEECARIVALFRSFGRAEVVPESLIHAVVGVSGSSPAYVF
CCCHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHH
MFIEAMADAVVRAGMPRAQAYQFAAQAVMGAAKMVLETGTHPAELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHH
AALEENGMRASVIEAITRCIAKSEAMSRR
HHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]