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The map label for this gene is ndk

Identifier: 238921043

GI number: 238921043

Start: 3055763

End: 3056194

Strand: Reverse

Name: ndk

Synonym: NT01EI_3173

Alternate gene names: 238921043

Gene position: 3056194-3055763 (Counterclockwise)

Preceding gene: 238921045

Following gene: 238921042

Centisome position: 80.17

GC content: 59.03

Gene sequence:

>432_bases
ATGACCTTAGAACGTACCTTTTCCATCGTAAAACCAAACGCGGTGGCCAAAAATGCCATCGGCGCCATCTACGCACGCTT
TGAGTCTGCCGGTCTGAAGATCGTCGCCGCCAAAATGGTGCACCTGACGCGCGAGCAGGCGGAAGGCTTCTACGCCGAAC
ATCGCGAGCGCCCTTTCTTTGACGGCTTGGTGACCTTCATGACCTCTGGCCCGATCATGGTGCAGGTGTTGGAAGGCAAT
GATGCGGTGCGTCGCAACCGTGAAATTATGGGCGCCACGAATCCGGAAAGCGCGCTGGCCGGTACGCTGCGCGCCGACTA
TGCCGATAGCCTGACAGAGAATGCAGTGCACGGCTCCGATTCTCCGGCCTCTGCCGAACGCGAAATCGCCTATTTCTTCA
GCGCCGACGATATCTGCCCGCGCACCCGCTGA

Upstream 100 bases:

>100_bases
TAACTCATGGTGTTAGCGTGGCCGGGTGGCTTTCTTTCGTCGCTGTTGCGCCGTAGAATCCCGCGCGGATGTTGATTAAA
GCTGTCTGACAGGGGTAGAC

Downstream 100 bases:

>100_bases
GCGCCATGCCAGCGCGCCAAAATCCCACCCGACTGCATTATCGCCATGGTATCGGTAGGCGAGAGTGGGTACAATGTGCC
GCCCCGTGCTTTCTCCGGGG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MTLERTFSIVKPNAVAKNAIGAIYARFESAGLKIVAAKMVHLTREQAEGFYAEHRERPFFDGLVTFMTSGPIMVQVLEGN
DAVRRNREIMGATNPESALAGTLRADYADSLTENAVHGSDSPASAEREIAYFFSADDICPRTR

Sequences:

>Translated_143_residues
MTLERTFSIVKPNAVAKNAIGAIYARFESAGLKIVAAKMVHLTREQAEGFYAEHRERPFFDGLVTFMTSGPIMVQVLEGN
DAVRRNREIMGATNPESALAGTLRADYADSLTENAVHGSDSPASAEREIAYFFSADDICPRTR
>Mature_142_residues
TLERTFSIVKPNAVAKNAIGAIYARFESAGLKIVAAKMVHLTREQAEGFYAEHRERPFFDGLVTFMTSGPIMVQVLEGND
AVRRNREIMGATNPESALAGTLRADYADSLTENAVHGSDSPASAEREIAYFFSADDICPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=48.1481481481481, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.1459854014599, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.1459854014599, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.1459854014599, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.1459854014599, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.1459854014599, Blast_Score=125, Evalue=1e-29,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=38.1294964028777, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=38.1294964028777, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=34.5323741007194, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=35.2517985611511, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=35.2517985611511, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.037037037037, Blast_Score=83, Evalue=7e-17,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=34.8148148148148, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=33.5766423357664, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=30.6569343065693, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=73.4265734265734, Blast_Score=224, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=40.7407407407407, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=47.0588235294118, Blast_Score=134, Evalue=6e-33,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=43.8848920863309, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18860097, Length=142, Percent_Identity=36.6197183098592, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_EDWI9 (C5BET5)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002934558.1
- GeneID:   7958691
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3173
- OMA:   ERPFFGA
- ProtClustDB:   CLSK2813566
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15687; Mature: 15556

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLERTFSIVKPNAVAKNAIGAIYARFESAGLKIVAAKMVHLTREQAEGFYAEHRERPFF
CCCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCCHHHHHCCCCHH
DGLVTFMTSGPIMVQVLEGNDAVRRNREIMGATNPESALAGTLRADYADSLTENAVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
SPASAEREIAYFFSADDICPRTR
CCCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TLERTFSIVKPNAVAKNAIGAIYARFESAGLKIVAAKMVHLTREQAEGFYAEHRERPFF
CCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHCCHHHHHCCCCHH
DGLVTFMTSGPIMVQVLEGNDAVRRNREIMGATNPESALAGTLRADYADSLTENAVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
SPASAEREIAYFFSADDICPRTR
CCCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA