Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 238920718

GI number: 238920718

Start: 2722671

End: 2723960

Strand: Direct

Name: bioA [H]

Synonym: NT01EI_2831

Alternate gene names: 238920718

Gene position: 2722671-2723960 (Clockwise)

Preceding gene: 238920709

Following gene: 238920719

Centisome position: 71.42

GC content: 65.12

Gene sequence:

>1290_bases
ATGAACGCCAGCGACCTCGACTTTGACCGCCGCCATATCTGGCACCCCTATACTTCGATGAGCCAGCCTCTGCCGGTGTA
CCCGGTAACGACGGCGTCCGGCTGCGAGCTGCAGCTGGCGGATGGCCGGCGTCTGGTGGACGGCATGTCCTCCTGGTGGG
CCGCCATTCATGGCTATAACCACCCCCACCTGAATCAGGCCGTTACGCGCCAGCTGGCGCAGATGGCCCATGTCATGTTC
GGCGGTGTCACCCATCCCTCGGCGGTCGCCCTGTGCCAAAAGCTGGTGGGGATGACCCCCCAGGCGCTGGAGTGCGTGTT
TCTGGCCGACTCCGGCTCCGTTGCCGTCGAGGTGGCACTGAAGATGGCGCTGCAGTACTGGCAGGCGCGCGGCGAACCGC
GCCAGCGCTTCCTCACCCTGCGTCAGGGCTACCACGGCGATACCTTTGGCGCCATGTCGGTATGCGATCCGGATACCTCG
ATGCACAGCCTGTACCGCGGCTATCTGCCGCAGCACCTGTTTGCCCCCGCACCGCAGTGCGCTTTCAACGCCGAATGGGA
CGAGGCGGATTTTGTCCCCTTCGCTCGCCTGCTGGCAGCCCATCACCGCGAGCTTGCCGCCGTGATCCTGGAGCCCATCG
TACAGGGCGCCGGTGGCATGCGCTTCTATCATCCATGCTACTTGCAGCGGGTGCGGCAGGCCTGCAGCCGCCACGGAGTG
CTGCTGATCGCCGATGAGATAGCCACCGGCTTTGGCCGCAGCGGGGCGCTGTTTGCCTGCGATCACGCCAAGGTAACCCC
GGATATTCTGTGCCTGGGCAAGGCGCTGACTGGCGGTTACATGACACTCGCCGCCACCCTGACCACCCGCAGCGTGGCCG
ACACCATCAGCAACGGCGAGGCGGGCTGCTTTATGCATGGCCCGACCTTTATGGCTAACCCGCTGGCCTGCGCTACGGCG
GTAGCCAGCCTGGAGCTTATCGAGCAGGGACACTGGCGCGCTCAGGTCGCCGCCATCGAGTCTCAGCTGCGAGCGGAGCT
GCTGCCGCTCAATGCGCACCCCCGCATACGCCAGGCGCGGGTGCTCGGCGCCATCGGGGTGCTGGAGACCCATCAACCGG
TCAATATGGCCGCCCTGCAGGCCTTCTTTGTCGAGCAGGGGGTGTGGATCCGTCCCTTCGGCCACCTGATCTACCTGATG
CCACCCTATCCGATCACCGCTGTGCAGCTGACACAGCTGACAGAGACAATCCGTGCGGCGCTGGCGTACGATGCCCATTT
TTCGACCTAA

Upstream 100 bases:

>100_bases
CAGGTAAATAGCGTAATATCGGAATGCTTGATGACTAAGCGGCGTTAACACGCTACACTGTAAACCAAAAAAACATAACA
AGGTTTACCTAAGTAATACC

Downstream 100 bases:

>100_bases
ATCTATTGCGCCCACATCGTCCATGGACAATGTTAACCCACCTGAATGACATAGCGCCCGGCACCGGGCACACCCTACAG
CCTCTGTACACGGAGAGTGA

Product: adenosylmethionine-8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNASDLDFDRRHIWHPYTSMSQPLPVYPVTTASGCELQLADGRRLVDGMSSWWAAIHGYNHPHLNQAVTRQLAQMAHVMF
GGVTHPSAVALCQKLVGMTPQALECVFLADSGSVAVEVALKMALQYWQARGEPRQRFLTLRQGYHGDTFGAMSVCDPDTS
MHSLYRGYLPQHLFAPAPQCAFNAEWDEADFVPFARLLAAHHRELAAVILEPIVQGAGGMRFYHPCYLQRVRQACSRHGV
LLIADEIATGFGRSGALFACDHAKVTPDILCLGKALTGGYMTLAATLTTRSVADTISNGEAGCFMHGPTFMANPLACATA
VASLELIEQGHWRAQVAAIESQLRAELLPLNAHPRIRQARVLGAIGVLETHQPVNMAALQAFFVEQGVWIRPFGHLIYLM
PPYPITAVQLTQLTETIRAALAYDAHFST

Sequences:

>Translated_429_residues
MNASDLDFDRRHIWHPYTSMSQPLPVYPVTTASGCELQLADGRRLVDGMSSWWAAIHGYNHPHLNQAVTRQLAQMAHVMF
GGVTHPSAVALCQKLVGMTPQALECVFLADSGSVAVEVALKMALQYWQARGEPRQRFLTLRQGYHGDTFGAMSVCDPDTS
MHSLYRGYLPQHLFAPAPQCAFNAEWDEADFVPFARLLAAHHRELAAVILEPIVQGAGGMRFYHPCYLQRVRQACSRHGV
LLIADEIATGFGRSGALFACDHAKVTPDILCLGKALTGGYMTLAATLTTRSVADTISNGEAGCFMHGPTFMANPLACATA
VASLELIEQGHWRAQVAAIESQLRAELLPLNAHPRIRQARVLGAIGVLETHQPVNMAALQAFFVEQGVWIRPFGHLIYLM
PPYPITAVQLTQLTETIRAALAYDAHFST
>Mature_429_residues
MNASDLDFDRRHIWHPYTSMSQPLPVYPVTTASGCELQLADGRRLVDGMSSWWAAIHGYNHPHLNQAVTRQLAQMAHVMF
GGVTHPSAVALCQKLVGMTPQALECVFLADSGSVAVEVALKMALQYWQARGEPRQRFLTLRQGYHGDTFGAMSVCDPDTS
MHSLYRGYLPQHLFAPAPQCAFNAEWDEADFVPFARLLAAHHRELAAVILEPIVQGAGGMRFYHPCYLQRVRQACSRHGV
LLIADEIATGFGRSGALFACDHAKVTPDILCLGKALTGGYMTLAATLTTRSVADTISNGEAGCFMHGPTFMANPLACATA
VASLELIEQGHWRAQVAAIESQLRAELLPLNAHPRIRQARVLGAIGVLETHQPVNMAALQAFFVEQGVWIRPFGHLIYLM
PPYPITAVQLTQLTETIRAALAYDAHFST

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=436, Percent_Identity=29.3577981651376, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=31.6770186335404, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI13994255, Length=319, Percent_Identity=28.2131661442006, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226442709, Length=307, Percent_Identity=27.0358306188925, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI37574042, Length=307, Percent_Identity=27.0358306188925, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI226442705, Length=280, Percent_Identity=27.8571428571429, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI24119277, Length=367, Percent_Identity=25.6130790190736, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=72.1311475409836, Blast_Score=643, Evalue=0.0,
Organism=Escherichia coli, GI145693181, Length=299, Percent_Identity=34.7826086956522, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789016, Length=432, Percent_Identity=27.0833333333333, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788044, Length=308, Percent_Identity=33.1168831168831, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789759, Length=317, Percent_Identity=32.807570977918, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=27.0731707317073, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786349, Length=330, Percent_Identity=26.969696969697, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=27.2941176470588, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI25144274, Length=233, Percent_Identity=33.0472103004292, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=26.1904761904762, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=374, Percent_Identity=24.331550802139, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=458, Percent_Identity=46.7248908296943, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6323470, Length=427, Percent_Identity=30.4449648711944, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=319, Percent_Identity=27.8996865203762, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357415, Length=428, Percent_Identity=29.2056074766355, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI28574759, Length=318, Percent_Identity=28.6163522012579, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161085790, Length=318, Percent_Identity=28.6163522012579, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356575, Length=305, Percent_Identity=27.5409836065574, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366494, Length=355, Percent_Identity=23.6619718309859, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667139, Length=355, Percent_Identity=23.6619718309859, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667143, Length=355, Percent_Identity=23.6619718309859, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47009; Mature: 47009

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASDLDFDRRHIWHPYTSMSQPLPVYPVTTASGCELQLADGRRLVDGMSSWWAAIHGYN
CCCCCCCCCHHHCCCCCCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
HPHLNQAVTRQLAQMAHVMFGGVTHPSAVALCQKLVGMTPQALECVFLADSGSVAVEVAL
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
KMALQYWQARGEPRQRFLTLRQGYHGDTFGAMSVCDPDTSMHSLYRGYLPQHLFAPAPQC
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHHCHHHHCCCCCCC
AFNAEWDEADFVPFARLLAAHHRELAAVILEPIVQGAGGMRFYHPCYLQRVRQACSRHGV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCE
LLIADEIATGFGRSGALFACDHAKVTPDILCLGKALTGGYMTLAATLTTRSVADTISNGE
EEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCC
AGCFMHGPTFMANPLACATAVASLELIEQGHWRAQVAAIESQLRAELLPLNAHPRIRQAR
CCEEEECCCHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGAIGVLETHQPVNMAALQAFFVEQGVWIRPFGHLIYLMPPYPITAVQLTQLTETIRAA
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHHH
LAYDAHFST
HHHCCCCCC
>Mature Secondary Structure
MNASDLDFDRRHIWHPYTSMSQPLPVYPVTTASGCELQLADGRRLVDGMSSWWAAIHGYN
CCCCCCCCCHHHCCCCCCCCCCCCCEEEECCCCCCEEEECCCCHHHHHHHHHHHHHCCCC
HPHLNQAVTRQLAQMAHVMFGGVTHPSAVALCQKLVGMTPQALECVFLADSGSVAVEVAL
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHH
KMALQYWQARGEPRQRFLTLRQGYHGDTFGAMSVCDPDTSMHSLYRGYLPQHLFAPAPQC
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHHCHHHHCCCCCCC
AFNAEWDEADFVPFARLLAAHHRELAAVILEPIVQGAGGMRFYHPCYLQRVRQACSRHGV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCE
LLIADEIATGFGRSGALFACDHAKVTPDILCLGKALTGGYMTLAATLTTRSVADTISNGE
EEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCC
AGCFMHGPTFMANPLACATAVASLELIEQGHWRAQVAAIESQLRAELLPLNAHPRIRQAR
CCEEEECCCHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGAIGVLETHQPVNMAALQAFFVEQGVWIRPFGHLIYLMPPYPITAVQLTQLTETIRAA
HHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEECCCEEEECCCCCCHHHHHHHHHHHHHHH
LAYDAHFST
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]