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The map label for this gene is ggt [H]

Identifier: 238920719

GI number: 238920719

Start: 2724063

End: 2725817

Strand: Direct

Name: ggt [H]

Synonym: NT01EI_2832

Alternate gene names: 238920719

Gene position: 2724063-2725817 (Clockwise)

Preceding gene: 238920718

Following gene: 238920720

Centisome position: 71.45

GC content: 60.23

Gene sequence:

>1755_bases
ATGACCCGATTCCTACGGCTGGCCACCCGTATCACGGCCCTGTTGACACTGCTGCCCCTGACCACGTTGCAGGCAGCAAC
GCTGCCCGCCATCGAGGCTCAACAGGGTGCGGTGGTCAGTGAACAGCGGTTAGCCTCCGCAGTGGGGTTACAGATCCTGC
AAGCCGGGGGCAACGCCGTTGATGCCGCCGTCGCGATGGGGTATGCGCTGGCCGTGGTCAATCCCTGCTGTGGCAATATT
GGCGGCGGTGGCTTTATGACGCTCCATCTGGCCAATGGCAAAAATACCTTTATCAATTTTCGTGAAAAAGCCCCCGCAGC
GGCCAGCGCCGACATGTATCTCAATGCCCAGGGCGAGCTACGCCCGGACAGTAGCCTGTATGGCTACCTCGCCGTCGCCG
TTCCAGGCACCGTCGCCGGGCTTGATCATGCACTACAGCGCTATGGCACGCTCACCCGCCAGCTGGTCATGGCACCGGCC
ATCCGCCTTGCCCGGCAAGGGTTTATCCTGACACGCGGTGATACCGATATCATCGATAGCCAACGGAGCCGGCTGTATGC
CGATCCGCTGGCGCGCGTACGTTTTTTCCGGCCTGATGGTAGCCCGCTGCAGCCTGGCGATCGCCTGACGCAACCTGAGC
TGGCCGATACCCTGCAGATGCTGGCTACGCAAGGCGCTCAGGCTTTCTACCACGGTGCATTACCGCAGGCCACCAGCCAG
GCGCTCCGTACCCACGGCGGTATCATCACGCCGCAAGACTTCGCCGACTACCGCATTAGTGAAACTCCGCCGATCTCCTG
TCACTACCGCGGTTACCAATTTCTCTCTTCTCCTCCGCCCAGCTCCGGCGGCATCACCCTGTGCCTGCTGCTCAATATTC
TGGAGGGGTATGATATCGCCCAGGCTGGATTTAACTCCGCCCAGAGCATCAGCTGGATGGTCGAGGCGATGCGTTACGCT
TATCAGGATCGTAATACTCTGTTAGGGGACCCCGACTTTGTCGATATCCCGGTCAAACGTCTGCTCAGTAAAGCCTATGC
CGCCGAGATCCGTCAGCGTATCAACACCGCGCAGCCGGGGTTAGCCGCTGCGCCACAGAGCAATAAAGAAAAGCCGGAGA
CGACCCACTACTCGGTCATTGATAAACAGGGGAATGCCGTCTCTACCACCTACACCCTTAACGGGCGCTTCGGTGCGCTA
GTCATGGCGCCAGGTGGATTCTTTCTCAATAATGAGATGGACGATTTCACGATCCAGCCGGGGAAAGCCAACCTGTATGG
CCTGGTTCAAGGGGAAAAAAATACCATCGCAGCGGGAAAACGTCCGCTCTCTTCCATGGCACCGACGCTGGTGTTACAAC
AGGAGCGGGTGGTTATGGCCCTTGGCTCCCCCGGCGGTTCGCGCATCATCAGCATCATCCTGCAAAATGCGCTGAACCTC
ATCGACCATGGCATGGCGCCGCAGGAGGCGATCGACGCCGCGCGTATTCACTATCAAGGGGTTCCGGATCGCCTATACAT
GGAGCAGCGCGGGCTCTCTCCGGATACCCAGAAACTCCTCCGCGCGCGTGGCTACACGCTGGAGGAGCAGACCCCCTGGG
GCGCAGCAGAAATCATTGTCCGCGCACCACTGTCAGCCTCTAAAACGGCAGCCAGCTCCGGCAATGATGCCGCACTCTCC
GGCGTAATGCGTCCCGGCCATCTCTACGCCGCCAGCGATGCCAGACGTCCCGCCGGTGCCGCTATGGGCTATTGA

Upstream 100 bases:

>100_bases
CTATTGCGCCCACATCGTCCATGGACAATGTTAACCCACCTGAATGACATAGCGCCCGGCACCGGGCACACCCTACAGCC
TCTGTACACGGAGAGTGACG

Downstream 100 bases:

>100_bases
TCCCGGCGCTGTCCCCCTGTGGACATCCGGTGTAACATTTGGCGCAAACCCCATTGATTTAAGGTATCGCCAATGCACTA
TCGCTTGATTGCCCTCGATC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MTRFLRLATRITALLTLLPLTTLQAATLPAIEAQQGAVVSEQRLASAVGLQILQAGGNAVDAAVAMGYALAVVNPCCGNI
GGGGFMTLHLANGKNTFINFREKAPAAASADMYLNAQGELRPDSSLYGYLAVAVPGTVAGLDHALQRYGTLTRQLVMAPA
IRLARQGFILTRGDTDIIDSQRSRLYADPLARVRFFRPDGSPLQPGDRLTQPELADTLQMLATQGAQAFYHGALPQATSQ
ALRTHGGIITPQDFADYRISETPPISCHYRGYQFLSSPPPSSGGITLCLLLNILEGYDIAQAGFNSAQSISWMVEAMRYA
YQDRNTLLGDPDFVDIPVKRLLSKAYAAEIRQRINTAQPGLAAAPQSNKEKPETTHYSVIDKQGNAVSTTYTLNGRFGAL
VMAPGGFFLNNEMDDFTIQPGKANLYGLVQGEKNTIAAGKRPLSSMAPTLVLQQERVVMALGSPGGSRIISIILQNALNL
IDHGMAPQEAIDAARIHYQGVPDRLYMEQRGLSPDTQKLLRARGYTLEEQTPWGAAEIIVRAPLSASKTAASSGNDAALS
GVMRPGHLYAASDARRPAGAAMGY

Sequences:

>Translated_584_residues
MTRFLRLATRITALLTLLPLTTLQAATLPAIEAQQGAVVSEQRLASAVGLQILQAGGNAVDAAVAMGYALAVVNPCCGNI
GGGGFMTLHLANGKNTFINFREKAPAAASADMYLNAQGELRPDSSLYGYLAVAVPGTVAGLDHALQRYGTLTRQLVMAPA
IRLARQGFILTRGDTDIIDSQRSRLYADPLARVRFFRPDGSPLQPGDRLTQPELADTLQMLATQGAQAFYHGALPQATSQ
ALRTHGGIITPQDFADYRISETPPISCHYRGYQFLSSPPPSSGGITLCLLLNILEGYDIAQAGFNSAQSISWMVEAMRYA
YQDRNTLLGDPDFVDIPVKRLLSKAYAAEIRQRINTAQPGLAAAPQSNKEKPETTHYSVIDKQGNAVSTTYTLNGRFGAL
VMAPGGFFLNNEMDDFTIQPGKANLYGLVQGEKNTIAAGKRPLSSMAPTLVLQQERVVMALGSPGGSRIISIILQNALNL
IDHGMAPQEAIDAARIHYQGVPDRLYMEQRGLSPDTQKLLRARGYTLEEQTPWGAAEIIVRAPLSASKTAASSGNDAALS
GVMRPGHLYAASDARRPAGAAMGY
>Mature_583_residues
TRFLRLATRITALLTLLPLTTLQAATLPAIEAQQGAVVSEQRLASAVGLQILQAGGNAVDAAVAMGYALAVVNPCCGNIG
GGGFMTLHLANGKNTFINFREKAPAAASADMYLNAQGELRPDSSLYGYLAVAVPGTVAGLDHALQRYGTLTRQLVMAPAI
RLARQGFILTRGDTDIIDSQRSRLYADPLARVRFFRPDGSPLQPGDRLTQPELADTLQMLATQGAQAFYHGALPQATSQA
LRTHGGIITPQDFADYRISETPPISCHYRGYQFLSSPPPSSGGITLCLLLNILEGYDIAQAGFNSAQSISWMVEAMRYAY
QDRNTLLGDPDFVDIPVKRLLSKAYAAEIRQRINTAQPGLAAAPQSNKEKPETTHYSVIDKQGNAVSTTYTLNGRFGALV
MAPGGFFLNNEMDDFTIQPGKANLYGLVQGEKNTIAAGKRPLSSMAPTLVLQQERVVMALGSPGGSRIISIILQNALNLI
DHGMAPQEAIDAARIHYQGVPDRLYMEQRGLSPDTQKLLRARGYTLEEQTPWGAAEIIVRAPLSASKTAASSGNDAALSG
VMRPGHLYAASDARRPAGAAMGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=490, Percent_Identity=36.1224489795918, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI73915090, Length=490, Percent_Identity=36.1224489795918, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI73915096, Length=490, Percent_Identity=36.1224489795918, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI73915094, Length=490, Percent_Identity=36.1224489795918, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI113429324, Length=490, Percent_Identity=34.2857142857143, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI113429326, Length=494, Percent_Identity=33.6032388663968, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI109148539, Length=509, Percent_Identity=32.4165029469548, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI153266885, Length=569, Percent_Identity=28.9982425307557, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI153266901, Length=570, Percent_Identity=28.9473684210526, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI153266907, Length=568, Percent_Identity=27.4647887323944, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI30581157, Length=193, Percent_Identity=33.160621761658, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI30581155, Length=193, Percent_Identity=33.160621761658, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI218505805, Length=181, Percent_Identity=30.939226519337, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1789856, Length=559, Percent_Identity=45.0805008944544, Blast_Score=468, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI212646519, Length=493, Percent_Identity=34.4827586206897, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI72000294, Length=493, Percent_Identity=34.4827586206897, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17506189, Length=499, Percent_Identity=33.4669338677355, Blast_Score=233, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI193208245, Length=502, Percent_Identity=32.4701195219124, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI193208247, Length=502, Percent_Identity=32.4701195219124, Blast_Score=225, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=485, Percent_Identity=31.1340206185567, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17564448, Length=436, Percent_Identity=27.2935779816514, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72001497, Length=243, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=243, Percent_Identity=25.9259259259259, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=536, Percent_Identity=28.7313432835821, Blast_Score=163, Evalue=8e-41,
Organism=Drosophila melanogaster, GI18859893, Length=514, Percent_Identity=32.6848249027237, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI161077496, Length=489, Percent_Identity=31.6973415132924, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24642670, Length=510, Percent_Identity=30.7843137254902, Blast_Score=205, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24642666, Length=510, Percent_Identity=30.7843137254902, Blast_Score=205, Evalue=9e-53,
Organism=Drosophila melanogaster, GI161077880, Length=510, Percent_Identity=30.7843137254902, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI45551474, Length=510, Percent_Identity=30.7843137254902, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI161077878, Length=510, Percent_Identity=30.7843137254902, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI18859741, Length=522, Percent_Identity=29.8850574712644, Blast_Score=176, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62514; Mature: 62383

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFLRLATRITALLTLLPLTTLQAATLPAIEAQQGAVVSEQRLASAVGLQILQAGGNAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
DAAVAMGYALAVVNPCCGNIGGGGFMTLHLANGKNTFINFREKAPAAASADMYLNAQGEL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEECCCCC
RPDSSLYGYLAVAVPGTVAGLDHALQRYGTLTRQLVMAPAIRLARQGFILTRGDTDIIDS
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHH
QRSRLYADPLARVRFFRPDGSPLQPGDRLTQPELADTLQMLATQGAQAFYHGALPQATSQ
HHHHHHHCCHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHH
ALRTHGGIITPQDFADYRISETPPISCHYRGYQFLSSPPPSSGGITLCLLLNILEGYDIA
HHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCHHCCCCCCCCCCHHHHHHHHHHCCCCHH
QAGFNSAQSISWMVEAMRYAYQDRNTLLGDPDFVDIPVKRLLSKAYAAEIRQRINTAQPG
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCC
LAAAPQSNKEKPETTHYSVIDKQGNAVSTTYTLNGRFGALVMAPGGFFLNNEMDDFTIQP
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCEEECCCCCCEEECC
GKANLYGLVQGEKNTIAAGKRPLSSMAPTLVLQQERVVMALGSPGGSRIISIILQNALNL
CCCCEEEEEECCCCCCCCCCCCHHHHCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHHH
IDHGMAPQEAIDAARIHYQGVPDRLYMEQRGLSPDTQKLLRARGYTLEEQTPWGAAEIIV
HHCCCCCHHHHHHHHHEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHEEE
RAPLSASKTAASSGNDAALSGVMRPGHLYAASDARRPAGAAMGY
ECCCCCCHHCCCCCCCHHHHHCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TRFLRLATRITALLTLLPLTTLQAATLPAIEAQQGAVVSEQRLASAVGLQILQAGGNAV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
DAAVAMGYALAVVNPCCGNIGGGGFMTLHLANGKNTFINFREKAPAAASADMYLNAQGEL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEECCCCC
RPDSSLYGYLAVAVPGTVAGLDHALQRYGTLTRQLVMAPAIRLARQGFILTRGDTDIIDS
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHH
QRSRLYADPLARVRFFRPDGSPLQPGDRLTQPELADTLQMLATQGAQAFYHGALPQATSQ
HHHHHHHCCHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCHHHHH
ALRTHGGIITPQDFADYRISETPPISCHYRGYQFLSSPPPSSGGITLCLLLNILEGYDIA
HHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCHHCCCCCCCCCCHHHHHHHHHHCCCCHH
QAGFNSAQSISWMVEAMRYAYQDRNTLLGDPDFVDIPVKRLLSKAYAAEIRQRINTAQPG
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCC
LAAAPQSNKEKPETTHYSVIDKQGNAVSTTYTLNGRFGALVMAPGGFFLNNEMDDFTIQP
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEEECCCEEECCCCCCEEECC
GKANLYGLVQGEKNTIAAGKRPLSSMAPTLVLQQERVVMALGSPGGSRIISIILQNALNL
CCCCEEEEEECCCCCCCCCCCCHHHHCCEEEEECCEEEEEECCCCHHHHHHHHHHHHHHH
IDHGMAPQEAIDAARIHYQGVPDRLYMEQRGLSPDTQKLLRARGYTLEEQTPWGAAEIIV
HHCCCCCHHHHHHHHHEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHEEE
RAPLSASKTAASSGNDAALSGVMRPGHLYAASDARRPAGAAMGY
ECCCCCCHHCCCCCCCHHHHHCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]