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The map label for this gene is menB [H]

Identifier: 238920536

GI number: 238920536

Start: 2542333

End: 2543190

Strand: Reverse

Name: menB [H]

Synonym: NT01EI_2648

Alternate gene names: 238920536

Gene position: 2543190-2542333 (Counterclockwise)

Preceding gene: 238920537

Following gene: 238920535

Centisome position: 66.71

GC content: 60.84

Gene sequence:

>858_bases
ATGCTGTATCCAAGCGAACAAGAGCTGTATGCCCCGATCGCATGGCAGGACTGCAGCGGCGACTTTGAGGATATCCTCTA
TCACAAGTCCGCCGACGGTATTGCCAAAATCACCATCAATCGCCCGCAGGTGCGCAACGCATTTCGCCCGCTGACGGTGA
AAGAGATGCTGCAGGCGCTGGCCGACGCGCGCTATGACGACGGTATCGGCGTGATCGTGCTGACCGGCGCCGGTGATAAG
GCGTTCTGCGCCGGCGGTGATCAGAAGATCCGCGGCGACTACGGCGGCTACCGCGATGACAGCGGCGTACATCACCTTAA
TGTCCTCGACTTTCAGCGTCAGATCCGTACCTGTCCGAAGCCGGTGGTGGCGATGGTGGCTGGCTATGCGGTCGGCGGGG
GCCACGTCCTGCATATGATGTGCGATCTGACCATCGCAGCACAGAATGCTCAGTTCGGTCAGACCGGCCCGAAGGTCGGC
TCCTTCGACGGCGGTTGGGGGGCATCTTATATGGCGCGCATCGTCGGCCAGAAAAAAGCCCGCGAGATCTGGTTCCTGTG
CCGGATGTATGACGCGCAGCAGGCGCTGGATATGGGGCTGGTCAACACGGTGGTGCCGCTGGAGGATCTGGAGAAAGAGA
CCGTACGCTGGTGCCGTGAGATGCTGCGCAACAGTCCGATGGCGCTGCGCTGCCTGAAGGCGGCGCTCAACGCTGACTGC
GATGGGCAGGCTGGCCTGCAGGAGCTGGCGGGGAATGCCACCATGCTGTTCTACATGACGGAAGAGGGGCAGGAAGGGCG
CAACGCATTTAACGAAAAGCGTCAGCCGGACTTTTCCAAGTTTAAGCGGAATCCGTAA

Upstream 100 bases:

>100_bases
CGTTTCGCGACGCGCTGGGAACCTTTTTAACGACATCAACCCCCGGCTGACGCGCCAGACGCGCCGCCGGGTCGGCATCT
TTATTAACAGGAAACGTATT

Downstream 100 bases:

>100_bases
TGCGTCAGGCCACGTTGTATCGCTATCGTCTGCCGGTGGACGCCGGTGTCGCGCTGCGTAACCAGCGGCTGAAAAGCCGC
GATGGGCTACTGGTGCGGCT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLYPSEQELYAPIAWQDCSGDFEDILYHKSADGIAKITINRPQVRNAFRPLTVKEMLQALADARYDDGIGVIVLTGAGDK
AFCAGGDQKIRGDYGGYRDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYAVGGGHVLHMMCDLTIAAQNAQFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRMYDAQQALDMGLVNTVVPLEDLEKETVRWCREMLRNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRQPDFSKFKRNP

Sequences:

>Translated_285_residues
MLYPSEQELYAPIAWQDCSGDFEDILYHKSADGIAKITINRPQVRNAFRPLTVKEMLQALADARYDDGIGVIVLTGAGDK
AFCAGGDQKIRGDYGGYRDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYAVGGGHVLHMMCDLTIAAQNAQFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRMYDAQQALDMGLVNTVVPLEDLEKETVRWCREMLRNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRQPDFSKFKRNP
>Mature_285_residues
MLYPSEQELYAPIAWQDCSGDFEDILYHKSADGIAKITINRPQVRNAFRPLTVKEMLQALADARYDDGIGVIVLTGAGDK
AFCAGGDQKIRGDYGGYRDDSGVHHLNVLDFQRQIRTCPKPVVAMVAGYAVGGGHVLHMMCDLTIAAQNAQFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRMYDAQQALDMGLVNTVVPLEDLEKETVRWCREMLRNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRQPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=272, Percent_Identity=34.5588235294118, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=32.6693227091633, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI45643119, Length=220, Percent_Identity=30.4545454545455, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI260275230, Length=220, Percent_Identity=30.4545454545455, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=30.4545454545455, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI4502327, Length=255, Percent_Identity=29.4117647058824, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI213417737, Length=224, Percent_Identity=25.4464285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=25.4464285714286, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI25453481, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI51538573, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4757966, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI51538581, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4757968, Length=240, Percent_Identity=26.25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI49355787, Length=240, Percent_Identity=26.25, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI70995211, Length=234, Percent_Identity=28.2051282051282, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI68989263, Length=206, Percent_Identity=31.0679611650485, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI37594469, Length=156, Percent_Identity=27.5641025641026, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI37594471, Length=156, Percent_Identity=27.5641025641026, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=90.5263157894737, Blast_Score=549, Evalue=1e-158,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=33.6032388663968, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87082183, Length=253, Percent_Identity=29.6442687747036, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787660, Length=268, Percent_Identity=30.5970149253731, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=32.9411764705882, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=32.258064516129, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17540714, Length=231, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=27.1428571428571, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=26.3959390862944, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=178, Percent_Identity=30.8988764044944, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536985, Length=223, Percent_Identity=24.2152466367713, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=35.3413654618474, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=35.3413654618474, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24653139, Length=270, Percent_Identity=29.2592592592593, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357171, Length=210, Percent_Identity=31.9047619047619, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24654903, Length=184, Percent_Identity=28.804347826087, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922422, Length=197, Percent_Identity=28.4263959390863, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24650670, Length=174, Percent_Identity=32.183908045977, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31571; Mature: 31571

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPSEQELYAPIAWQDCSGDFEDILYHKSADGIAKITINRPQVRNAFRPLTVKEMLQAL
CCCCCCCHHCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCHHHHHHHH
ADARYDDGIGVIVLTGAGDKAFCAGGDQKIRGDYGGYRDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCCEEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYAVGGGHVLHMMCDLTIAAQNAQFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRMYDAQQALDMGLVNTVVPLEDLEKETVRWCREMLRNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MLYPSEQELYAPIAWQDCSGDFEDILYHKSADGIAKITINRPQVRNAFRPLTVKEMLQAL
CCCCCCCHHCCCEEECCCCCCHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCHHHHHHHH
ADARYDDGIGVIVLTGAGDKAFCAGGDQKIRGDYGGYRDDSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCCEEECCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYAVGGGHVLHMMCDLTIAAQNAQFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHHHCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRMYDAQQALDMGLVNTVVPLEDLEKETVRWCREMLRNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]