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The map label for this gene is hisC [H]

Identifier: 238920455

GI number: 238920455

Start: 2458423

End: 2459499

Strand: Direct

Name: hisC [H]

Synonym: NT01EI_2566

Alternate gene names: 238920455

Gene position: 2458423-2459499 (Clockwise)

Preceding gene: 238920454

Following gene: 238920456

Centisome position: 64.49

GC content: 65.37

Gene sequence:

>1077_bases
ATGAAGCCGATAACCGCACTGGCGCGGGAAAACATACAGCGCCTGACCCCCTACCAGTCCGCCCGACGCCTCGGTGGCAG
CGGCGACGTCTGGCTCAATGCCAACGAGTACCCGCAGCCGGTCAGCTATCCGCTGCGCAGCGAGGCCTTTAACCGCTACC
CGGAGTGCCAGCCCGCCGAGCTTATCGCCAACTACGCCGCCTATGCCGGCGTCACGGCGCAGCAGGTGCTGGCCAGCCGC
GGCGCCGATGAGGGCATCGAGCTGCTGATCCGCACCTTTTGCGAACCGGGGCGCGACGCCATGATCTACTGTCCGCCCAC
CTACGGCATGTACGCCGTCAGCGCGGAGAGCAGCGGCGTCGAACGGCGCTGCGTCGCGCTGGGCACCGACTGGCAGCTGG
ACGTGCCAGCCATCGCCGCCACCCTCGACGGCGTCAGGCTGGTGTTTGTCTGCAGTCCCAACAACCCGACCGGCAACCTG
CTCAATCCCGACGATCTGCGCACACTGCTCACGCTGACCGCCGGGCGGGCGCTGGTGGTGGTGGATGAGGCCTACATTGA
GTTTGCCCCCGACGCCAGCGTGGTCTCCTGGCTCGCCGACTACCCCCATCTGGTGGTGCTGCGTACCCTCTCGAAGGCCT
TTGCCCTGGCCGGGCTACGCTGCGGCTTCACGCTGGCCAGCGCCGAGGTGATCGCTTTGCTGCAGAAAACCATCGCCCCT
TATCCTTTGGCATCACCGGTCGCCGACATCGCGGCCCAGGCCACCTCGCCCGCCGGGATTGCCGCCATGCGGACGCGGGT
TGCCTACGTGATTGAACAGCGCCAGGCGCTGATCGCACAGTTATTGCGCTGCGACTGCATTCAAGAGGTCTATCCTTCTC
AGGGAAACTATCTAATCATCCGCAGTGACCGCGCAGGATCGATCTTTCAGGCCCTGTGGCAGCAGGGCATCATTCTGCGC
GATCAGCGCAGCCAGCCCTCGCTGGCCGACTGCCTGCGCATCACCATCGGCAGCACCGTGGAGCATGAGCGGGTTCTTGC
GGTACTGCGCCATTTTAGCCAGGAAGGAGAGGCGTAA

Upstream 100 bases:

>100_bases
CGCTGGCCCCGACGGTCGAGGCCATGGCGCAGGCTGAGTGCCTTGACGCCCACGCCAACGCCGTCCGCCTGCGGGTCGCC
GCCATCCGGGAGAGCCAATC

Downstream 100 bases:

>100_bases
ATGAAGAAATATCTGTTTATCGATCGCGACGGCACCCTGATCGCCGAGCCGCCGCAGGACTTTCAGGTAGACCGTCTGGA
CAAGCTGGCGCTGATGCCCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKPITALARENIQRLTPYQSARRLGGSGDVWLNANEYPQPVSYPLRSEAFNRYPECQPAELIANYAAYAGVTAQQVLASR
GADEGIELLIRTFCEPGRDAMIYCPPTYGMYAVSAESSGVERRCVALGTDWQLDVPAIAATLDGVRLVFVCSPNNPTGNL
LNPDDLRTLLTLTAGRALVVVDEAYIEFAPDASVVSWLADYPHLVVLRTLSKAFALAGLRCGFTLASAEVIALLQKTIAP
YPLASPVADIAAQATSPAGIAAMRTRVAYVIEQRQALIAQLLRCDCIQEVYPSQGNYLIIRSDRAGSIFQALWQQGIILR
DQRSQPSLADCLRITIGSTVEHERVLAVLRHFSQEGEA

Sequences:

>Translated_358_residues
MKPITALARENIQRLTPYQSARRLGGSGDVWLNANEYPQPVSYPLRSEAFNRYPECQPAELIANYAAYAGVTAQQVLASR
GADEGIELLIRTFCEPGRDAMIYCPPTYGMYAVSAESSGVERRCVALGTDWQLDVPAIAATLDGVRLVFVCSPNNPTGNL
LNPDDLRTLLTLTAGRALVVVDEAYIEFAPDASVVSWLADYPHLVVLRTLSKAFALAGLRCGFTLASAEVIALLQKTIAP
YPLASPVADIAAQATSPAGIAAMRTRVAYVIEQRQALIAQLLRCDCIQEVYPSQGNYLIIRSDRAGSIFQALWQQGIILR
DQRSQPSLADCLRITIGSTVEHERVLAVLRHFSQEGEA
>Mature_358_residues
MKPITALARENIQRLTPYQSARRLGGSGDVWLNANEYPQPVSYPLRSEAFNRYPECQPAELIANYAAYAGVTAQQVLASR
GADEGIELLIRTFCEPGRDAMIYCPPTYGMYAVSAESSGVERRCVALGTDWQLDVPAIAATLDGVRLVFVCSPNNPTGNL
LNPDDLRTLLTLTAGRALVVVDEAYIEFAPDASVVSWLADYPHLVVLRTLSKAFALAGLRCGFTLASAEVIALLQKTIAP
YPLASPVADIAAQATSPAGIAAMRTRVAYVIEQRQALIAQLLRCDCIQEVYPSQGNYLIIRSDRAGSIFQALWQQGIILR
DQRSQPSLADCLRITIGSTVEHERVLAVLRHFSQEGEA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=347, Percent_Identity=65.7060518731988, Blast_Score=485, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=31.2169312169312, Blast_Score=172, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38999; Mature: 38999

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPITALARENIQRLTPYQSARRLGGSGDVWLNANEYPQPVSYPLRSEAFNRYPECQPAE
CCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCHHH
LIANYAAYAGVTAQQVLASRGADEGIELLIRTFCEPGRDAMIYCPPTYGMYAVSAESSGV
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCC
ERRCVALGTDWQLDVPAIAATLDGVRLVFVCSPNNPTGNLLNPDDLRTLLTLTAGRALVV
CCEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEE
VDEAYIEFAPDASVVSWLADYPHLVVLRTLSKAFALAGLRCGFTLASAEVIALLQKTIAP
EEHHHHEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCC
YPLASPVADIAAQATSPAGIAAMRTRVAYVIEQRQALIAQLLRCDCIQEVYPSQGNYLII
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RSDRAGSIFQALWQQGIILRDQRSQPSLADCLRITIGSTVEHERVLAVLRHFSQEGEA
ECCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKPITALARENIQRLTPYQSARRLGGSGDVWLNANEYPQPVSYPLRSEAFNRYPECQPAE
CCCHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCHHH
LIANYAAYAGVTAQQVLASRGADEGIELLIRTFCEPGRDAMIYCPPTYGMYAVSAESSGV
HHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCC
ERRCVALGTDWQLDVPAIAATLDGVRLVFVCSPNNPTGNLLNPDDLRTLLTLTAGRALVV
CCEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEE
VDEAYIEFAPDASVVSWLADYPHLVVLRTLSKAFALAGLRCGFTLASAEVIALLQKTIAP
EEHHHHEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCC
YPLASPVADIAAQATSPAGIAAMRTRVAYVIEQRQALIAQLLRCDCIQEVYPSQGNYLII
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RSDRAGSIFQALWQQGIILRDQRSQPSLADCLRITIGSTVEHERVLAVLRHFSQEGEA
ECCCCCHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA